Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations

Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and -dynamics studies of KDM1A inhibitors

(2019) Cristina Mascaró et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

(2019) Jun Mukai et al.   NEURON

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

(2018) Tamara Maes et al.   CANCER CELL

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

(2018) Alba Maiques-Diaz et al.   Cell Reports

Herpes viruses and Alzheimer's disease: new evidence in the debate

(2018) Brian J Balin et al.   LANCET NEUROLOGY

CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies

(2018) Nathan O. Fuller et al.   ACS Chemical Neuroscience

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

(2018) Satoru Matsuda et al.   NEUROPSYCHOPHARMACOLOGY

BAIAP3, a C2 domain–containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells

(2017) Xingmin Zhang et al.   JOURNAL OF CELL BIOLOGY

TDP-43 and Cytoskeletal Proteins in ALS

(2017) Moritz Oberstadt et al.   MOLECULAR NEUROBIOLOGY

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity

(2017) Francesco Rusconi et al.   TRENDS IN NEUROSCIENCES

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

(2016) Willem Kamphuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

(2016) Vinzon Ibanez et al.   BLOOD

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

(2016) Annemarie Zimprich et al.   MOLECULAR NEUROBIOLOGY

LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior

(2016) Francesco Rusconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway

(2015) Shun-Mei Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Converging evidence of social avoidant behavior in schizophrenia from two approach-avoidance tasks

(2015) Javier de la Asuncion et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

(2015) Benoit Laurent et al.   MOLECULAR CELL

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

(2015) Jianxun Wang et al.   NATURE NEUROSCIENCE

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

(2015) F. F. Wagner et al.   Chemical Science

Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development

(2014) Xiao Han et al.   MOLECULAR CELL

Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice

(2014) Seungrie Han et al.   MOLECULES AND CELLS

7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

(2014) Antonio Adamo et al.   NATURE GENETICS

S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model

(2014) Hee Jin Kim et al.   PLoS One

The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis

(2014) Anna Schnell et al.   PLoS One

Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation

(2014) G. Upadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

(2014) J. M. Hill et al.   Science Translational Medicine

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance

(2014) Feng Zhang et al.   Nature Communications

The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade

(2013) Chao Wang et al.   ACTA NEUROPATHOLOGICA

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

(2013) Kumpei Tanisawa et al.   BMC GENOMICS

An Epigenetic Trap Stabilizes Singular Olfactory Receptor Expression

(2013) David B. Lyons et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2

(2013) Emanuela Toffolo et al.   JOURNAL OF NEUROCHEMISTRY

Assessment of social interaction and anxiety-like behavior in senescence-accelerated-prone and -resistant mice

(2013) Harry C. Meeker et al.   PHYSIOLOGY & BEHAVIOR

Characterization of GABAergic Neurons in the Mouse Lateral Septum: A Double Fluorescence In Situ Hybridization and Immunohistochemical Study Using Tyramide Signal Amplification

(2013) Changjiu Zhao et al.   PLoS One

Rare event of histone demethylation can initiate singular gene expression of olfactory receptors

(2013) L. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia

(2013) Jean-François Poulin et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency

(2013) Y. Liang et al.   mBio

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

Mrp14 Deficiency Ameliorates Amyloid   Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing

(2012) M. P. Kummer et al.   JOURNAL OF NEUROSCIENCE

Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation

(2011) Ramesh Neelamegam et al.   ACS Chemical Neuroscience

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

(2011) John E. Morley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Post-weaning social isolation induces abnormal forms of aggression in conjunction with increased glucocorticoid and autonomic stress responses

(2011) Mate Toth et al.   HORMONES AND BEHAVIOR

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory Consolidation in Drosophila

(2011) Jason R. Gerstner et al.   PLoS One

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions

(2010) Takeshi Sakurai et al.   Autism Research

Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

(2010) Marisa Möller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System

(2010) C. Zibetti et al.   JOURNAL OF NEUROSCIENCE

Gfi1 and Gfi1b: key regulators of hematopoiesis

(2010) L T van der Meer et al.   LEUKEMIA

Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

(2010) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency

(2009) Yu Liang et al.   NATURE MEDICINE

Transrepressive Function of TLX Requires the Histone Demethylase LSD1

(2008) A. Yokoyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors

(2008) S.-Y. Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25Å

(2007) Shinya Mimasu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Networks of neurons, networks of genes: An integrated view of memory consolidation

(2007) Teiko Miyashita et al.   NEUROBIOLOGY OF LEARNING AND MEMORY