Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice

(2019) Jessica M. Ferrell et al.   HEPATOLOGY

Molecular Pathogenesis of Cholangiocarcinoma

(2019) Peter L. Labib et al.   BMC CANCER

Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability

(2018) Jun Peng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model

(2018) François Briand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis

(2018) Nahum Mendez-Sanchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The balancing act of the liver: tissue regeneration versus fibrosis

(2018) Lucía Cordero-Espinoza et al.   JOURNAL OF CLINICAL INVESTIGATION

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

(2018) Samer Al-Dury et al.   Frontiers in Pharmacology

Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance

(2018) Azhwar Raghunath et al.   Cancers

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

(2017) Na Jiao et al.   GUT

Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation

(2017) Latifa Bakiri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice

(2017) Peng-Fei Ma et al.   JOURNAL OF HEPATOLOGY

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

(2017) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Macrophage Phenotype in Liver Injury and Repair

(2017) Y.-Y. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

(2017) Omar A. Mesarwi et al.   PLoS One

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease

(2016) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Bile Acids and the Potential Role in Primary Biliary Cirrhosis

(2016) Hang Yang et al.   DIGESTION

Prolonged feeding with green tea polyphenols exacerbates cholesterol-induced fatty liver disease in mice

(2016) Nina Hirsch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress

(2016) Luis E. Gomez-Quiroz et al.   TOXICOLOGY

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Obeticholic acid for the treatment of primary biliary cirrhosis

(2016) David E. J. Jones   Expert Review of Gastroenterology & Hepatology

Fatty liver diseases, bile acids, and FXR

(2016) Yan Zhu et al.   Acta Pharmaceutica Sinica B

Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration

(2015) Yuhong Zou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

(2015) Graciela Arguello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target

(2015) Lei Zhan et al.   BIOCHIMIE

The role of iNOS in cholesterol-induced liver fibrosis

(2015) Sarit Anavi et al.   LABORATORY INVESTIGATION

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

(2015) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RNAi Knockdown of Hypoxia-Inducible Factor-1α Decreased the Proliferation, Migration, and Invasion of Hypoxic Hepatocellular Carcinoma Cells

(2014) ChengShi Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Mechanism for HIF-1 activation by cholesterol under normoxia: A redox signaling pathway for liver damage

(2014) Sarit Anavi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer

(2013) Abigale Lade et al.   CURRENT OPINION IN ONCOLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Unknown

(2013) Rania Dayoub et al.   MOLECULAR MEDICINE

A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth

(2013) Ming Lu et al.   Journal of Molecular Cell Biology

Fibrosis-dependent mechanisms of hepatocarcinogenesis

(2012) David Y. Zhang et al.   HEPATOLOGY

Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes

(2012) Yuki Abe et al.   SURGERY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

(2011) Toshiaki Teratani et al.   GASTROENTEROLOGY

Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice

(2011) Roja Barikbin et al.   HEPATOLOGY

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

Cholesterol: recapitulation of its active role during liver regeneration

(2011) Blanca Delgado-Coello et al.   LIVER INTERNATIONAL

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis

(2009) Heather Basciano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bile acid levels are increased in the liver of patients with steatohepatitis

(2009) Márcia M. Aranha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY