Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide

Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype

(2018) Tianfu Yu et al.   CANCER LETTERS

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

(2018) Sabine Hombach-Klonisch et al.   PHARMACOLOGY & THERAPEUTICS

NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation

(2018) Seung Min Um et al.   Cell Reports

Synapse maintenance and restoration in the retina by NGL2

(2018) Florentina Soto et al.   eLife

Deptor: not only a mTOR inhibitor

(2017) Valeria Catena et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

Novel Therapy for Glioblastoma Multiforme by Restoring LRRC4 in Tumor Cells: LRRC4 Inhibits Tumor-Infitrating Regulatory T Cells by Cytokine and Programmed Cell Death 1-Containing Exosomes

(2017) Peiyao Li et al.   Frontiers in Immunology

Targeting autophagy to sensitive glioma to temozolomide treatment

(2016) Yuanliang Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

(2016) Zeyou Wang et al.   Journal of Hematology & Oncology

Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas

(2015) Alfeu Zanotto-Filho et al.   CANCER LETTERS

NGL-2 Is a New Partner of PAR Complex in Axon Differentiation

(2015) G. Xu et al.   JOURNAL OF NEUROSCIENCE

Function and mechanism of tumor suppressor gene LRRC4/NGL-2

(2015) Peiyao Li et al.   Molecular Cancer

An Evolving Role for DEPTOR in Tumor Development and Progression

(2015) Zhiwei Wang et al.   NEOPLASIA

Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells

(2014) Yusuke S. Hori et al.   JOURNAL OF NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Current evidence of temozolomide and bevacizumab in treatment of gliomas

(2014) Danop Nanegrungsunk et al.   NEUROLOGICAL RESEARCH

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Understanding and Targeting Alkylator Resistance in Glioblastoma

(2014) W. Wick et al.   Cancer Discovery

Autophagy

(2013) Amber N. Hale et al.   Autophagy

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Autophagy modulation for cancer therapy

(2011) Zhineng J. Yang et al.   CANCER BIOLOGY & THERAPY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

Autophagy Signaling Through Reactive Oxygen Species

(2010) Ju Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses

(2009) Jooyeon Woo et al.   NATURE NEUROSCIENCE

Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma

(2008) Anastasia Murat et al.   JOURNAL OF CLINICAL ONCOLOGY

Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness

(2007) W. Zhang et al.   GENES BRAIN AND BEHAVIOR