Rislenemdaz treatment in the lateral habenula improves despair-like behavior in mice

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects

(2019) Manoela V. Fogaça et al.   NEUROPSYCHOPHARMACOLOGY

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline

(2018) David Castonguay et al.   CURRENT BIOLOGY

Lateral habenula in the pathophysiology of depression

(2018) Yan Yang et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets

(2018) Elisabeth Lang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets

(2018) F. Caraci et al.   PHARMACOLOGICAL REVIEWS

A neural pathway controlling motivation to exert effort

(2018) Christophe D. Proulx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

Exposure to Stressors Facilitates Long-Term Synaptic Potentiation in the Lateral Habenula

(2017) Hoyong Park et al.   JOURNAL OF NEUROSCIENCE

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

(2017) S-X Li et al.   MOLECULAR PSYCHIATRY

Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders

(2017) Mehdi Ghasemi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior

(2017) Oliver H. Miller et al.   Cell Reports

Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder

(2016) Brittany Jaso et al.   Current Neuropharmacology

Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus

(2016) P. Leon Brown et al.   JOURNAL OF NEUROSCIENCE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism

(2015) Carly Kiselycznyk et al.   BEHAVIOURAL BRAIN RESEARCH

A structural biology perspective on NMDA receptor pharmacology and function

(2015) Michael C Regan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inhibition of in vivo [3H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice

(2015) Alda Fernandes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GluN2B-Containing NMDA Receptors Blockade Rescues Bidirectional Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis of Cocaine Self-Administering Rats

(2014) Julian deBacker et al.   NEUROPSYCHOPHARMACOLOGY

The role of NMDA receptors in the pathophysiology and treatment of mood disorders

(2014) Mehdi Ghasemi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat

(2013) Chemutai Sego et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Brain-Derived Neurotrophic Factor Induces Matrix Metalloproteinase 9 Expression in Neurons via the Serum Response Factor/c-Fos Pathway

(2013) B. Kuzniewska et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain

(2013) Juan M. Lima-Ojeda et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder

(2012) Lobna Ibrahim et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence

(2011) Fani L. Neto et al.   Current Neuropharmacology

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

(2011) Chih-Chieh Wang et al.   NEURON

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression

(2009) Esra Küçükibrahimoğlu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus

(2007) Li-Min Yang et al.   BEHAVIOURAL BRAIN RESEARCH