Identification of a potent and selective covalent Pin1 inhibitor

Discovery of a selective inhibitor of doublecortin like kinase 1

(2020) Fleur M. Ferguson et al.   Nature Chemical Biology

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer

(2018) Concetta Russo Spena et al.   JOURNAL OF CONTROLLED RELEASE

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

(2018) Shingo Kozono et al.   Nature Communications

Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

(2018) Sainan An et al.   EBioMedicine

An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity

(2018) Naoya Ieda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells

(2018) Chen Liang et al.   CANCER RESEARCH

A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification

(2018) Christopher M. Browne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transcription control by the ENL YEATS domain in acute leukaemia

(2017) Michael A. Erb et al.   NATURE

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

(2017) Elena Campaner et al.   Nature Communications

Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes

(2016) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

Proteome-wide covalent ligand discovery in native biological systems

(2016) Keriann M. Backus et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

(2015) Chun-Hau Chen et al.   NEUROBIOLOGY OF DISEASE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

(2015) Asaf Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for structure refinement inPHENIX

(2015) Paul Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION A

The Ess1 prolyl isomerase: Traffic cop of the RNA polymerase II transcription cycle

(2014) Steven D. Hanes   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket

(2014) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer

(2014) M.-L. Luo et al.   CANCER RESEARCH

Prolyl isomerase Pin1 in cancer

(2014) Zhimin Lu et al.   CELL RESEARCH

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

(2013) Jonathan D. Moore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

(2013) A. S. Farrell et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibitor Mediated Protein Degradation

(2012) Marcus J.C. Long et al.   CHEMISTRY & BIOLOGY

The Methionine-aromatic Motif Plays a Unique Role in Stabilizing Protein Structure

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Dynamical structural science

(2010) E. Collet   ACTA CRYSTALLOGRAPHICA SECTION A

multiplierz: an extensible API based desktop environment for proteomics data analysis

(2009) Jignesh R Parikh et al.   BMC BIOINFORMATICS

Cell Growth and Size Homeostasis in Proliferating Animal Cells

(2009) A. Tzur et al.   SCIENCE