Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro

(2018) Jérome Chal et al.   DEVELOPMENT

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

(2017) Kyosuke Hino et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Human Somitogenesis Guides Somite Development from hPSCs

(2017) Haibin Xi et al.   Cell Reports

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

(2016) Kyle M. Loh et al.   CELL

Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro

(2016) Jérome Chal et al.   Nature Protocols

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis

(2016) Hidetsugu Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

(2016) D. Dey et al.   Science Translational Medicine

Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm

(2016) Smita Sudheer et al.   STEM CELLS

The developmental basis of mesenchymal stem/stromal cells (MSCs)

(2015) Guojun Sheng   BMC DEVELOPMENTAL BIOLOGY

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells

(2015) D. Iyer et al.   DEVELOPMENT

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy

(2015) Jérome Chal et al.   NATURE BIOTECHNOLOGY

Generation of articular chondrocytes from human pluripotent stem cells

(2015) April M Craft et al.   NATURE BIOTECHNOLOGY

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

(2015) Kyosuke Hino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva

(2015) Yoshihisa Matsumoto et al.   STEM CELLS

Bone Morphogenetic Protein 7 (BMP-7) Influences Tendon-Bone Integration In Vitro

(2015) Tim Schwarting et al.   PLoS One

Small molecule-directed specification of sclerotome-like chondroprogenitors and induction of a somitic chondrogenesis program from embryonic stem cells

(2014) J. Zhao et al.   DEVELOPMENT

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media

(2014) Makoto Fukuta et al.   PLoS One

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

(2014) Masato Nakagawa et al.   Scientific Reports

Formation and Segmentation of the Vertebrate Body Axis

(2013) Bertrand Bénazéraf et al.   Annual Review of Cell and Developmental Biology

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation

(2013) Yoshihisa Matsumoto et al.   Orphanet Journal of Rare Diseases

Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro

(2013) Akihito Tanaka et al.   PLoS One

Characterization of mechanical and biochemical properties of developing embryonic tendon

(2013) J. E. Marturano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells

(2013) M. Koyanagi-Aoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic acid signalling during development

(2012) M. Rhinn et al.   DEVELOPMENT

In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells

(2012) Hidetoshi Sakurai et al.   PLoS One

Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells

(2012) Tomonari Awaya et al.   PLoS One

Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells

(2012) Katsutsugu Umeda et al.   Scientific Reports

Retinoic acid synthesis and functions in early embryonic development

(2012) Richard Kin Ting Kam et al.   Cell and Bioscience

FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression

(2011) Katharine M Hardy et al.   BMC DEVELOPMENTAL BIOLOGY

BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

(2011) Andreia S. Bernardo et al.   Cell Stem Cell

Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells

(2011) Tatsuya Takemoto et al.   NATURE

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

BMP-12 Treatment of Adult Mesenchymal Stem Cells In Vitro Augments Tendon-Like Tissue Formation and Defect Repair In Vivo

(2011) Jonathan Y. Lee et al.   PLoS One

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo

(2010) Mounia Lagha et al.   BMC GENOMICS

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells

(2010) Christopher A. Fasano et al.   Cell Stem Cell

Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-β/activin/nodal signaling using SB-431542

(2010) Amer Mahmood et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Directed differentiation of human embryonic stem cells toward chondrocytes

(2010) Rachel A Oldershaw et al.   NATURE BIOTECHNOLOGY

Recruitment and maintenance of tendon progenitors by TGF  signaling are essential for tendon formation

(2009) B. A. Pryce et al.   DEVELOPMENT

Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis

(2009) Elena Tzouanacou et al.   DEVELOPMENTAL CELL

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium

(2009) Hidetoshi Sakurai et al.   Stem Cell Research

Signaling Gradients during Paraxial Mesoderm Development

(2009) A. Aulehla et al.   Cold Spring Harbor Perspectives in Biology

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/ -catenin, Activin/Nodal and BMP signaling

(2008) T. Sumi et al.   DEVELOPMENT