Theoretical Studies Aimed at Finding FLT3 Inhibitors and a Promising Compound and Molecular Pattern with Dual Aurora B/FLT3 Activity

Overcoming Resistance to FLT3 Inhibitors in the Treatment of FLT3-Mutated AML

(2020) Stephen S.Y. Lam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Δ-FeOOH as Support for Immobilization Peroxidase: Optimization via a Chemometric Approach

(2020) Tássia Silva Tavares et al.   MOLECULES

Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

(2019) Annette Böhmer et al.   Redox Biology

Indolin-2-one Derivatives: Theoretical Studies Aimed at Finding More Potent Aurora B Kinase Inhibitors

(2018) Italo Fernandes et al.   Letters in Drug Design & Discovery

FLT3 inhibitors in acute myeloid leukemia

(2018) Mei Wu et al.   Journal of Hematology & Oncology

Design, synthesis and biological evaluation of indolin-2-one-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase3 (FLT3)

(2017) Fei Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

(2017) Bao Nguyen et al.   Oncotarget

Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)

(2015) Julie A. Zorn et al.   PLoS One

Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: a systematic review and meta-analysis

(2014) M. Port et al.   ANNALS OF HEMATOLOGY

Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

(2012) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

(2012) A S Moore et al.   LEUKEMIA

Docking studies and effects of syn-anti isomery of oximes derived from pyridine imidazol bicycled systems as potential human acetylcholinesterase reactivators

(2011) Ana Paula Guimarães et al.   Journal of Applied Biomedicine

Development of new acetylcholinesterase reactivators: Molecular modeling versus in vitro data

(2010) Teodorico C. Ramalho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome

(2009) S. Kayser et al.   BLOOD

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD