Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

(2011) L. Li et al.   BLOOD

Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia

(2011) B. Lowenberg et al.   BLOOD

The clinical development of FLT3 inhibitors in acute myeloid leukemia

(2011) Steven Knapper   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Will newer tyrosine kinase inhibitors have an impact in AML?

(2010) Mark J. Levis   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Independent prognostic variables in acute myeloid leukaemia

(2010) Matthew L. Smith et al.   BLOOD REVIEWS

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate

(2010) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias

(2010) A S Moore et al.   LEUKEMIA

FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML

(2009) K. W. Pratz et al.   BLOOD

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro

(2009) N. von Bubnoff et al.   CANCER RESEARCH

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia

(2008) M. Raghavan et al.   BLOOD