Article
Biochemistry & Molecular Biology
Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu
Summary: Omega-3 PUFAs rich in fish oil are believed to prevent obesity by improving lipid metabolism and regulating gut microbiota. Microalgae oil, particularly Schizochytrium microalgae oil (SMO) with a high DHA proportion, is shown to have comparable weight-loss effects to commercial fish oil and a weight-loss drug. In addition, SMO has different effects on gut microbiota, increasing the abundance of beneficial bacteria and inhibiting obesity-promoting bacteria. SMO also helps restore the disturbed metabolic capability of gut microbiota caused by a high-fat diet.
Article
Microbiology
Pan Zhuang, Haoyu Li, Wei Jia, Qiyang Shou, Ya'er Zhu, Lei Mao, Wenqiao Wang, Fei Wu, Xiaoqian Chen, Xuzhi Wan, Yuqi Wu, Xiaohui Liu, Yin Li, Fanghuan Zhu, Lilin He, Jingnan Chen, Yu Zhang, Jingjing Jiao
Summary: The study found that DHA and EPA can significantly alleviate hyperglycemia and insulin resistance by altering the gut microbiome and metabolites, thereby improving symptoms of diabetes, with EPA showing a more pronounced effect.
Article
Food Science & Technology
Wanxiu Cao, Fang Liu, Robert W. Li, Yaoxian Chin, Yuming Wang, Changhu Xue, Qingjuan Tang
Summary: It is unclear how docosahexaenoic acid (DHA) improves insulin resistance via modulating gut microbiome in obese individuals. This study used a diet-induced obesity (DIO) mouse model to investigate the effects of DHA-rich fish oil (DHA-FO) on metabolic disorders and colonic microbiome. The results showed that DHA-FO reduced fat deposition, regulated lipid profiles, and alleviated insulin resistance by preventing the permeation of lipopolysaccharide and promoting peptide YY (PYY) secretion. DHA-FO also reversed microbial dysbiosis and altered gut microbial function, which were associated with PYY expression. Overall, DHA-FO enhanced insulin action on glucose metabolism by modulating gut microbiome and facilitating colonic PYY expression in DIO mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Environmental Sciences
Ursula Strandberg, Minna Hiltunen, Jari Syvaeranta, Eti E. Levi, Thomas A. Davidson, Erik Jeppesen, Michael T. Brett
Summary: Climate change and eutrophication are key stressors for shallow freshwater ecosystems and have significant impacts on phytoplankton community structure. This study found that nutrient treatment had a significant effect on phytoplankton EPA and DHA concentrations, while warming had a marginal effect. The changes in EPA and DHA concentrations were mostly related to the phytoplankton community structure and biomass.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Miguel Damas-Fuentes, Jose Carlos Fernandez-Garcia, Francisco J. Tinahones
Summary: Obesity is a chronic disease that is closely associated with type 2 diabetes. The dialogue between adipocytes and pancreatic beta cells plays a critical role in the development of these conditions, and emerging actors such as the gut microbiome may also have an impact.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zaiqi Han, Lu Yao, Yue Zhong, Yang Xiao, Jing Gao, Zhaozheng Zheng, Sijia Fan, Ziheng Zhang, Shanggang Gong, Sheng Chang, Xiaona Cui, Jianhui Cai
Summary: Research suggests that curcumin enhances Ucp1-dependent thermogenesis and improves obesity induced by high-fat diet by restructuring the gut microbiota, altering bile acid metabolism, and activating the TGR5 signaling pathway. It demonstrates the potential of manipulating the gut microbiota through nutrition and pharmacology to enhance Ucp1-dependent thermogenesis in the prevention and treatment of obesity.
Article
Biochemistry & Molecular Biology
Yu Zhang, Lilin He, Xiaoqian Chen, Ping Shentu, Yingke Xu, Jingjing Jiao
Summary: Ω-3 PUFAs may regulate glucose homeostasis imbalance and insulin resistance by promoting GLUT4 vesicle trafficking, improving cellular glucose transport, and enhancing Akt phosphorylation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Manoj Kumar, Namrata Pal, Poonam Sharma, Manoj Kumawat, Devojit Kumar Sarma, Bilkees Nabi, Vinod Verma, Rajnarayan R. Tiwari, Swasti Shubham, Bahram Arjmandi, Ravinder Nagpal
Summary: This paper provides insights into the potential role of omega-3 fatty acids in the management of Type-2 diabetes mellitus (T2DM) by influencing gut dysbiosis. By reviewing and discussing the molecular mechanisms and signaling pathways, the paper explores the associations between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and its related comorbidities. Moreover, the significance of gut microbiota in T2DM prevention and treatment is highlighted along with the potential of omega-3 fatty acids to positively modulate gut microbiota, leading to the discovery of new targets and therapeutic strategies for T2DM.
Article
Biochemistry & Molecular Biology
Xiaohua Yang, Xin Yi, Fenglin Zhang, Fan Li, Limin Lang, Mingfa Ling, Xumin Lai, Lin Chen, Lulu Quan, Yiming Fu, Shengchun Feng, Gang Shu, Lina Wang, Xiaotong Zhu, Ping Gao, Qingyan Jiang, Songbo Wang
Summary: The study revealed that CYP epoxygenase-derived EPA and DHA oxylipins 17,18-EpETE and 19,20-EpDPE promote BAT thermogenesis and WAT browning through the GPR120-AMPK alpha signaling pathway, contributing to the thermogenic and anti-obesity effects of fish oil.
Article
Biochemistry & Molecular Biology
Haoyu Li, Pan Zhuang, Yu Zhang, Qiyang Shou, Yanhua Lu, Guangfa Wang, Jieni Qiu, Jun Wang, Lilin He, Jingnan Chen, Jingjing Jiao
Summary: Conjugated linoleic acid (CLA) can decrease body weight and increase energy expenditure through the gut-adipose axis, but it modulates insulin resistance in a sex-dependent manner in both males and females.
Article
Biochemistry & Molecular Biology
Viswanathan Saraswathi, Narendra Kumar, Weilun Ai, Thiyagarajan Gopal, Saumya Bhatt, Edward N. Harris, Geoffrey A. Talmon, Cyrus Desouza
Summary: The intake of myristic acid (MA) exacerbates obesity-associated insulin resistance, partially mediated by increased adipose tissue inflammation and secretion of resistin.
Article
Chemistry, Applied
Ryota Hosomi, Anna Matsudo, Koki Sugimoto, Takaki Shimono, Seiji Kanda, Toshimasa Nishiyama, Munehiro Yoshida, Kenji Fukunaga
Summary: This study evaluated the effects of dietary EPA-ethyl ester (EE) and DHA-EE on steroid metabolism, gut microbiota, and bacterial metabolites in Wistar rats. The results showed that rats fed with DHA had lower microbiota diversity indices and significant differences in the relative abundance of microbiota at the genus level compared to rats fed with EPA or SOY diets. Therefore, it was concluded that EPA and DHA have different effects on the diversity and composition of gut microbiota under the experimental conditions.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Wenting Wei, Manjiang Hu, Jie Huang, Siyan Yu, Xudong Li, Yanhui Li, Limei Mao
Summary: The study found that DHA and EPA have different mechanisms in anti-obesity in insulin-resistant mice. Specifically, 1% DHA and EPA can inhibit adipogenesis by regulating GPR120, while 4% DHA can stimulate browning of adipose tissue by up-regulating PPAR-γ, improving insulin resistance and inflammatory infiltration.
Article
Agricultural Engineering
Nikhil L. Kadalag, Pratik R. Pawar, Gunjan Prakash
Summary: In this study, co-cultivation of Phaeodactylum tricornutum with Aurantiochytrium limacinum was used as a unique strategy to achieve the desired fatty acid composition. The initial cell density ratio was modulated to overcome the dominance of A. limacinum and regulate the proliferation of both species, resulting in the production of polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), as well as monounsaturated fatty acids (MUFA) and pigments.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Fei Wu, Lei Mao, Yu Zhang, Xiaoqian Chen, Pan Zhuang, Wenqiao Wang, Jun Wang, Jingjing Jiao
Summary: This study found that the intake of medium chain saturated fatty acids (MCSFA) was associated with an increased risk of overweight/obesity, especially decanoic acid (10:0). On the other hand, hexanoic acid (6:0) intake was linked to a lower risk of overweight/obesity.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Pan Zhuang, Xiaohui Liu, Yin Li, Xuzhi Wan, Yuqi Wu, Fei Wu, Yu Zhang, Jingjing Jiao
Summary: The study found a significant negative interaction between dietary quality and genetic predisposition to T2D, with adherence to a healthy diet associated with reduced T2D risk among individuals with higher genetic risk. While the most significant reduction in T2D risk associated with increased diet quality score was observed in the high GRS group, the simultaneous increase in GRS and diet quality score was further linked to lower T2D risk.
Article
Endocrinology & Metabolism
Pan Zhuang, Xiaohui Liu, Yin Li, Haoyu Li, Lange Zhang, Xuzhi Wan, Yuqi Wu, Yu Zhang, Jingjing Jiao
Summary: Plasma concentrations of saturated fatty acids and monounsaturated fatty acids were associated with a higher risk of T2D, while polyunsaturated fatty acids, n-6 and n-3 PUFA were related to a lower risk. Circulating MUFA and n-3 PUFA had significant interactions with genetic predisposition to T2D and FA-associated variants.
Article
Nutrition & Dietetics
Xiaohui Liu, Pan Zhuang, Yin Li, Fei Wu, Xuzhi Wan, Yu Zhang, Jingjing Jiao
Summary: Fish oil supplementation is associated with a lower risk of all-cause dementia among older adults, but not with any specific subtype of dementia. A marginal interaction was found between fish oil supplementation and APOE gene variants.
CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Lilin He, Xiaoqian Chen, Ping Shentu, Yingke Xu, Jingjing Jiao
Summary: Ω-3 PUFAs may regulate glucose homeostasis imbalance and insulin resistance by promoting GLUT4 vesicle trafficking, improving cellular glucose transport, and enhancing Akt phosphorylation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Yuqi Wu, Yu Zhang, Jingjing Jiao
Summary: This review summarizes the association between n-3 PUFAs and MetS by discussing the effects of n-3 PUFAs on telomere attrition, modulation of neuronal function, and regulation of the neuro-endocrine-immune network. It also speculates on the epidemiological associations between metabolic disorders, n-3 PUFAs, and telomere length, while suggesting promising biochemical approaches and methodologies to overcome inter-variation issues in future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Lange Zhang, Jiahao Jiang, Wei Jia, Xuzhi Wan, Yaoran Li, Jingjing Jiao, Yu Zhang
Summary: This research aimed to establish a multi-compartment PBTK model based on updated time-course datasets, accurately predicting the toxicokinetic characteristics of perchlorate in urine, blood, and thyroid in rats. The sensitivity analysis and repeated exposure simulations confirmed the model's effective renal clearance. The correlation study of internal and external exposure provided valuable tools for analyzing and modeling total exposure levels in the short term.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Li Zhu, Wei Jia, Xuzhi Wan, Pan Zhuang, Guicen Ma, Jingjing Jiao, Yu Zhang
Summary: Research has found that heterocyclic aromatic amines (HAAs) are present not only in cooked foods and cigarette smoke, but also in airborne particles and diesel-exhaust particles. It remains unclear how these hazardous compounds interfere with metabolic networks and act as biomarkers. This study used advanced technology to analyze urinary metabolomics and revealed that HAAs significantly disrupt various metabolic pathways.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Shanyun Wu, Yuqi Wu, Jingnan Chen, Pan Zhuang, Yu Zhang, Jingjing Jiao
Summary: Lifelong dietary intervention with DHA can slow down aging, attenuate telomere attrition, improve mitochondrial function, reduce oxidative stress and inflammation, and potentially be used in the treatment of telomere-related diseases and prolonging lifespan.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jia Shen, Yin Li, Meihui Xu, Fei Wu, Yanjie Jiang, Xiaohui Liu, Yang Ao, Qianru Lin, Pan Zhuang, Jingjing Jiao, Weifang Zheng, Yu Zhang
Summary: This study aimed to assess the association between egg intake and colorectal polyp prevalence. Through a food frequency questionnaire and electronic colonoscopy, it was found that high egg consumption was significantly correlated with a higher prevalence of colorectal polyps among the Chinese population at a high risk of CRC. However, this association disappeared after further adjustment for dietary cholesterol. Replacing egg intake with total dairy products was associated with a decrease in colorectal polyp prevalence.
Article
Nutrition & Dietetics
Xiaohui Liu, Xuzhi Wan, Lange Zhang, Yin Li, Yang Ao, Pan Zhuang, Yuqi Wu, Yu Zhang, Jingjing Jiao
Summary: This study found that the sulfur microbial diet score, which is associated with obesity, is positively related to the risk of obesity and abdominal obesity. It was also observed that there is no significant interaction between genetic risk and the sulfur microbial diet on obesity incidence. These results emphasize the importance of avoiding the sulfur microbial diet for obesity prevention across genetic risk levels.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Jingnan Chen, Shanyun Wu, Yuqi Wu, Pan Zhuang, Yu Zhang, Jingjing Jiao
Summary: This study found that docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, has a protective effect on premature aging caused by telomerase deficiency in male mice. DHA can attenuate telomere attrition and promote lipid synthesis by regulating the metabolic pathway.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Editorial Material
Nutrition & Dietetics
Jingjing Jiao
Article
Nutrition & Dietetics
Xiaohui Liu, Yin Li, Xuzhi Wan, Pan Zhuang, Yuqi Wu, Lange Zhang, Yang Ao, Jianxin Yao, Yu Zhang, Jingjing Jiao
Summary: This study aimed to explore the association between habitual intake of fish oil supplementation and the risk of developing CHD in patients with prediabetes and diabetes. It found that the consumption of fish oil supplements was linked to decreased serum CRP and VLDL-C levels and subsequent CHD risk among adults with prediabetes and diabetes. The findings highlight the important role of the habitual intake of fish oil supplements in preventing CHD in individuals with impaired glucose metabolism.
Article
Multidisciplinary Sciences
Pan Zhuang, Xiaohui Liu, Yin Li, Yuqi Wu, Haoyu Li, Xuzhi Wan, Lange Zhang, Chengfu Xu, Jingjing Jiao, Yu Zhang
Summary: This study investigated the relationship between fatty acids, genetic predisposition, and coronary artery disease. The results showed that monounsaturated fatty acids were positively associated with CAD risk, while polyunsaturated fatty acids were associated with a decreased risk. Individuals with high genetic risk should reduce saturated fatty acid levels for CAD prevention.