Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through the GPR120-AMPKα signaling pathway

Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling

(2020) Kyungtae Kim et al.   Nutrients

Obesity Phenotypes, Diabetes, and Cardiovascular Diseases

(2020) Marie-Eve Piché et al.   CIRCULATION RESEARCH

Obesity, Hypertension, and Bariatric Surgery

(2020) Rohan Samson et al.   CURRENT HYPERTENSION REPORTS

The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation

(2020) Thomas Jansen et al.   Antioxidants

20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance

(2020) Ankit Gilani et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Brown and Brite: The Fat Soldiers in the Anti-obesity Fight

(2019) Shireesh Srivastava et al.   Frontiers in Physiology

Epigenetics in Human Obesity and Type 2 Diabetes

(2019) Charlotte Ling et al.   Cell Metabolism

Calcium Supplementation Alleviates High-Fat Diet-Induced Estrous Cycle Irregularity and Subfertility Associated with Concomitantly Enhanced Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

(2019) Fenglin Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation

(2019) Byong-Keol Min et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Attenuation of obesity and insulin resistance by fish oil supplementation is associated with improved skeletal muscle mitochondrial function in mice fed a high-fat diet

(2018) Amanda R. Martins et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

(2018) Wolf-Hagen Schunck et al.   PHARMACOLOGY & THERAPEUTICS

Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet

(2018) Fenglin Zhang et al.   Food & Function

Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid

(2018) Yosuke Isobe et al.   Scientific Reports

Rutin ameliorates obesity through brown fat activation

(2017) Xiaoxue Yuan et al.   FASEB JOURNAL

The 17,18-epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques

(2017) Takahiro Nagatake et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increasing cAMP levels of preadipocytes by cyanidin-3-glucoside treatment induces the formation of beige phenotypes in 3T3-L1 adipocytes

(2017) Toshiya Matsukawa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)

(2017) Charles Austin Pickens et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

(2017) Jenny M. Hoffmann et al.   Cell Reports

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors

(2017) Bo Wang et al.   Cell Discovery

Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2and Toll-like receptor/MyD88 pathways

(2016) Kanae Echizen et al.   CANCER SCIENCE

Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms

(2016) Yuya Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides

(2016) Weicang Wang et al.   Obesity

CYP450-derived oxylipins mediate inflammatory resolution

(2016) Derek W. Gilroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice

(2016) Weicang Wang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

(2015) S Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway

(2015) Nami Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

(2015) Minji Kim et al.   Scientific Reports

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes

(2014) Ming Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of oxylipins in thrombosis and diabetes

(2014) Benjamin E. Tourdot et al.   Frontiers in Pharmacology

Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid

(2013) Tadafumi Kubota et al.   FASEB JOURNAL

Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets

(2013) Maaike J. Bruins et al.   JOURNAL OF LIPID RESEARCH

Differentially Expressed miRNAs after GnRH Treatment and Their Potential Roles in FSH Regulation in Porcine Anterior Pituitary Cell

(2013) Rui-Song Ye et al.   PLoS One

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Adipocyte Heme Oxygenase-1 Induction Attenuates Metabolic Syndrome in Both Male and Female Obese Mice

(2010) Angela Burgess et al.   HYPERTENSION

Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

(2010) Nadine Stahmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition or Deletion of Soluble Epoxide Hydrolase Prevents Hyperglycemia, Promotes Insulin Secretion, and Reduces Islet Apoptosis

(2010) P. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats

(2009) Angelique Nicolai et al.   HYPERTENSION

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

(2008) Pavel Flachs et al.   CLINICAL SCIENCE

Prostaglandin E2 negatively regulates AMP-activated protein kinase via protein kinase A signaling pathway

(2008) Koji Funahashi et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS