USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

(2020) Ya-Ting Wang et al.   Nature Microbiology

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

USP19 Inhibits TNF-α– and IL-1β–Triggered NF-κB Activation by Deubiquitinating TAK1

(2019) Cao-Qi Lei et al.   JOURNAL OF IMMUNOLOGY

NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation

(2019) Su-Ho Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

(2019) Katherine A. Michaelis et al.   Nature Communications

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

(2019) Xin Wu et al.   Nature Communications

NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma

(2018) Ying Liu et al.   BIOCHEMICAL JOURNAL

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells

(2018) Claudia Cristina Motran et al.   Frontiers in Immunology

Physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway

(2018) Ning Ding et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolic regulation of macrophage phenotype and function

(2017) Shilpi Saha et al.   IMMUNOLOGICAL REVIEWS

The intra- and extracellular functions of ASC specks

(2017) Bernardo S Franklin et al.   IMMUNOLOGICAL REVIEWS

NLRP3 inflammasome mediates interleukin-1βproduction in immune cells in response toAcinetobacter baumanniiand contributes to pulmonary inflammation in mice

(2017) Min-Jung Kang et al.   IMMUNOLOGY

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

(2017) Yu Zhang et al.   Nature Communications

The BECN1-USP19 axis plays a role in the crosstalk between autophagy and antiviral immune responses

(2016) Jun Cui et al.   Autophagy

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1

(2016) Shouheng Jin et al.   EMBO JOURNAL

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability

(2016) Min Wu et al.   Oncotarget

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4

(2015) Inhwa Hwang et al.   IMMUNOLOGY AND CELL BIOLOGY

NLRP3 moonlights in TH2 polarization

(2015) Jenny P Y Ting et al.   NATURE IMMUNOLOGY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

(2014) Vanessa M. Hubbard-Lucey et al.   IMMUNITY

Characterization of the Deubiquitinating Activity of USP19 and Its Role in Endoplasmic Reticulum-associated Degradation

(2013) Jin-Gu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GM-CSF in the generation of dendritic cells from human blood monocyte precursors: Recent advances

(2008) Lucia Conti et al.   IMMUNOBIOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE