Article
Biophysics
Tom J. Zajdel, Gawoon Shim, Daniel J. Cohen
Summary: Bioelectric wound treatment and electrotaxis have attracted growing interest for their potential role in wound healing, but the lack of experimental evidence demonstrating the direct acceleration of wound closure by electrotaxis alone has led to a lack of standardization in research methods. Researchers have developed a 'healing-on-chip' approach as a low-cost, standardized model for investigating electrically accelerated wound healing, demonstrating its effectiveness in closing wounds faster through convergent electrotaxis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Multidisciplinary Sciences
Christoph Gnendiger, Mohcine Chraibi, Antoine Tordeux
Summary: We investigated the simulation of passenger dynamics on escalators and found a discrepancy between the 'theoretical' and 'practical' capacity. We introduced a space-continuous model to describe the transition of agents on the escalator and used numerical findings to study key measures like minimum distances between standing agents and average occupancies. We obtained a generalized analytical formula for escalator capacity and discovered the importance of human reaction time in determining capacity.
Article
Rheumatology
Philip Mease, Filip van den Bosch
Summary: IL-23 plays a key role in the pathogenesis of spondyloarthritides, but the efficacy of IL-23 inhibition varies in different types of spondylitis, requiring further research.
Editorial Material
Oncology
Anna C. Greene, Brian A. Van Tine
Summary: Research on desmoid tumors is transforming the way they are managed, as it has been found that one third of desmoid tumors spontaneously regress. Collaboration between patient foundations and academia is driving rapid advancements in understanding and treating desmoid tumors.
CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Nataliya E. Borisova, Alexandre M. Fedoseev, Galina V. Kostikova, Petr I. Matveev, Leonid Yu. Starostin, Marina N. Sokolova, Mariia V. Evsiunina
Summary: This study provides a comprehensive understanding of the potential of 2,2'-bipyridine-6,6'-dicarboxamide as an actinide separation agent, revealing the structure and properties of its extraction species, as well as the mechanism of metal ion-induced bond rotation restriction.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Patrick L. Fernandez, Richard W. Nagorski, Judith R. Cristobal, Tina L. Amyes, John P. Richard
Summary: The study reveals that certain enzymes utilize substrate dianion binding energy for enzyme activation, which has been thoroughly documented in enzymes catalyzing glycolysis reactions. This suggests that this catalytic motif has been widely propagated in the proteome.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Tim Y. Hou, W. Lee Kraus
Summary: The complementary papers by Nguyen et al. (2021) and Baek et al. (2021) track the assembly of pre-initiation complexes at gene promoters using single-molecule microscopy, revealing dynamic spatiotemporal regulation of transcription initiation.
Article
Management
Abhishek Deshmane, Victor Martinez-de-Albeniz
Summary: Artist collaborations in music have been increasing and have led to successful songs both commercially and critically. This study aims to understand the impact of these collaborations on artists' careers and identify the factors that contribute to their success in the short and long term. Using data from radio plays, Spotify, and cultural dimensions, the study finds that releasing a collaboration song increases an artist's future plays by 4.6%, with a larger impact on current and subsequent songs compared to past songs. The effect is influenced by economic, social, and cultural factors, such as the partner's capital and cultural differences. This research provides insights into the mechanisms behind successful artist collaborations.
MANAGEMENT SCIENCE
(2023)
Article
Economics
Laura Alfaro, Nick Bloom, Paola Conconi, Harald Fadinger, Patrick Legros, Andrew F. Newman, Raffaella Sadun, John Van Reenen
Summary: We study the relationship between firm boundaries, decision rights and integration using an incomplete-contracts model and data on vertical integration and delegation for global firms. Our findings suggest that integration provides the authority to delegate or centralize decision rights, depending on the ability to solve problems in uncertain production processes. Consistent with the model, we observe that firms are more likely to integrate suppliers of valuable inputs and those operating in industries with dispersed productivity. Firms also delegate more decisions to integrated suppliers of valuable inputs and those in more productive industries.
JOURNAL OF THE EUROPEAN ECONOMIC ASSOCIATION
(2023)
Article
Plant Sciences
Rebecca C. Burkart, Ali Eljebbawi, Yvonne Stahl
Summary: Plants, as sessile organisms, must adapt to changing environmental conditions. They respond to these constraints through gene regulation and the formation of biomolecular condensates called bodies. This article summarizes the current knowledge about body-forming transcriptional regulators and discusses their role in plant-environment interactions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Rodrigo Caetano, Yaroslav Ispolatov, Michael Doebeli
Summary: The study found that the diversity of species in ecosystems is influenced by physiological tradeoffs. If the tradeoffs are non-linear, the system will either not diversify or diversify into a number of coexisting species that do not exceed the number of resources. Specificlly, very high diversity can only be observed for linear tradeoffs.
Article
Biology
Steff Horemans, Matthaios Pitoulias, Alexandria Holland, Emilie Pateau, Christophe Lechaplais, Dariy Ekaterina, Alain Perret, Panos Soultanas, Laurent Janniere
Summary: The study shows that PykA in Bacillus subtilis plays a crucial role in DNA replication, with PEPut acting as an initiation inhibitor and Cat as a replication fork speed activator. PykA modulates the activities of essential enzymes for replication initiation and elongation. PEPut regulates PykA activity, and determinants of Cat and PEPut are important for PykA's replication functions.
Article
Biotechnology & Applied Microbiology
Rosanna Young, Matthew Haines, Marko Storch, Paul S. Freemont
Summary: Synthetic Biology is a rapidly growing interdisciplinary field that considers living systems as programmable at the genetic level, defining new platform technologies and methodological advances. A key concept driving the field is the Design-Build Test-Learn cycle, which provides a systematic framework for building new biological systems, with a major application area being biosynthetic pathway engineering requiring modular assembly of genetic elements and enzymes.
METABOLIC ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Manon Moreau, Soukaina Benhaddou, Rodolphe Dard, Stefania Tolu, Rim Hamze, Francois Vialard, Jamileh Movassat, Nathalie Janel
Summary: Down syndrome is a genetic disorder caused by an extra copy of chromosome 21, leading to intellectual disabilities. Research has shown improvements in life expectancy for Down syndrome patients, but there is a need to address complications like obesity and diabetes to enhance their quality of life. Understanding the molecular mechanisms linking Down syndrome with metabolic disorders such as Type 1 and Type 2 diabetes could help identify new drug targets for therapeutic solutions.
Editorial Material
Ecology
Victor S. Saito, Daniel M. Perkins, Pavel Kratina
Summary: Metabolism scales with temperature influencing neutral community assembly processes and controlling population dynamics independently of species identities. This perspective offers new insights into the prevalence of niche and neutral processes through universal energetic constraints.
TRENDS IN ECOLOGY & EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Qifang Xu, Kimberly L. Malecka, Lauren Fink, E. Joseph Jordan, Erin Duffy, Samuel Kolander, Jeffrey R. Peterson, Roland L. Dunbrack
Article
Biochemistry & Molecular Biology
Qifang Xu, Kimberly L. Malecka, Lauren Fink, E. Joseph Jordan, Erin Duffy, Samuel Kolander, Jeffrey R. Peterson, Roland L. Dunbrack
Article
Cell Biology
Krisna C. Duong-Ly, Karthik Devarajan, Shuguang Liang, Kurumi Y. Horiuchi, Yuren Wang, Haiching Ma, Jeffrey R. Peterson
Article
Cell Biology
Alison M. Kurimchak, Claude Shelton, Kelly E. Duncan, Katherine J. Johnson, Jennifer Brown, Shane O'Brien, Rashid Gabbasov, Lauren S. Fink, Yuesheng Li, Nicole Lounsbury, Magid Abou-Gharbia, Wayne E. Childers, Denise C. Connolly, Jonathan Chernoff, Jeffrey R. Peterson, James S. Duncan
Article
Cell Biology
Sajitha A. Anthony, Anika L. Burrell, Matthew C. Johnson, Krisna C. Duong-Ly, Yin-Ming Kuo, Jacqueline C. Simonet, Peter Michener, Andrew Andrews, Justin M. Kollman, Jeffrey R. Peterson
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Oncology
Alexander Beatty, Lauren S. Fink, Tanu Singh, Alexander Strigun, Erik Peter, Christina M. Ferrer, Emmanuelle Nicolas, Kathy Q. Cai, Timothy P. Moran, Mauricio J. Reginato, Ulrike Rennefahrt, Jeffrey R. Peterson
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Cell Biology
Krisna C. Duong-Ly, Yin-Ming Kuo, Matthew C. Johnson, Joy M. Cote, Justin M. Kollman, Jonathan Soboloff, Glenn F. Rall, Andrew J. Andrews, Jeffrey R. Peterson
JOURNAL OF CELL SCIENCE
(2018)
Article
Chemistry, Medicinal
R. S. K. Vijayan, Peng He, Vivek Modi, Krisna C. Duong-Ly, Haiching Ma, Jeffrey R. Peterson, Roland L. Dunbrack, Ronald M. Levy
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Oncology
Lauren S. Fink, Alexander Beatty, Karthik Devarajan, Suraj Peri, Jeffrey R. Peterson
MOLECULAR CANCER THERAPEUTICS
(2015)
Article
Oncology
Anna A. Kiseleva, Vladislav A. Korobeynikov, Anna S. Nikonova, Peishan Zhang, Petr Makhov, Alexander Y. Deneka, Margret B. Einarson, Ilya G. Serebriiskii, Hanqing Liu, Jeffrey R. Peterson, Erica A. Golemis
CLINICAL CANCER RESEARCH
(2019)
Article
Biology
Jacqueline C. Simonet, Maya J. Foster, Eric M. Lynch, Justin M. Kollman, Emmanuelle Nicholas, Alana M. O'Reilly, Jeffrey R. Peterson
Article
Multidisciplinary Sciences
Alexander Beatty, Tanu Singh, Yulia Y. Tyurina, Vladimir A. Tyurin, Svetlana Samovich, Emmanuelle Nicolas, Kristen Maslar, Yan Zhou, Kathy Q. Cai, Yinfei Tan, Sebastian Doll, Marcus Conrad, Aravind Subramanian, Valerian E. Kagan, Ulrike Rennefahrt, Jeffrey R. Peterson, Hulya Bayir
Summary: Inhibition of lipid peroxidase GPX4 promotes ferroptotic cell death. A complementary approach using conjugated linolenic fatty acids has been identified, triggering lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids. This may provide a potential therapeutic strategy for cancer treatment.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anika L. Burrell, Chuankai Nie, Meerit Said, Jacqueline C. Simonet, David Fernandez-Justel, Matthew C. Johnson, Joel Quispe, Ruben M. Buey, Jeffrey R. Peterson, Justin M. Kollman
Summary: A series of cryo-EM structures of human IMPDH1 variants reveal polymorphic filaments. Blindness-associated mutations in IMPDH1 are characterized and half disrupt feedback inhibition. These findings provide a foundation for understanding the role of IMPDH1 in retinal function and disease.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Tanu Singh, Alexander Beatty, Jeffrey R. Peterson
Summary: The study identifies NUAK2 as a regulator of GPX4 expression and ferroptotic sensitivity, suggesting its potential as a biomarker for breast cancer patients who may respond to GPX4 inhibition therapy.
CELL DEATH DISCOVERY
(2022)
