期刊
MOLECULAR BIOLOGY OF THE CELL
卷 31, 期 12, 页码 1201-1205出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E18-10-0675
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资金
- National Institutes of Health [R01GM-118396, R01GM-083025, F31EY-030732, T32 CA-009035]
Many different enzymes in intermediate metabolism dynamically assemble filamentous polymers in cells, often in response to changes in physiological conditions. Most of the enzyme filaments known to date have only been observed in cells, but in a handful of cases structural and biochemical studies have revealed the mechanisms and consequences of assembly. In general, enzyme polymerization functions as a mechanism to allosterically tune enzyme kinetics, and it may play a physiological role in integrating metabolic signaling. Here, we highlight some principles of metabolic filaments by focusing on two well-studied examples in nucleotide biosynthesis pathways-inosine-5'-monophosphate (IMP) dehydrogenase and cytosine triphosphate (CTP) synthase.
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