The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2

(2021) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

(2021) Zhixian Wang et al.   ONCOLOGY REPORTS

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

(2021) Alexander Beatty et al.   Nature Communications

ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells

(2021) Xiao Han et al.   BREAST CANCER RESEARCH AND TREATMENT

Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

(2021) Pengchong Li et al.   NATURE IMMUNOLOGY

NUAK1 and NUAK2 Fine-Tune TGF-β Signaling

(2021) Reinofke A. J. van de Vis et al.   Cancers

The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction

(2021) Kai Fan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NUAK Kinases: Brain–Ovary Axis

(2021) Ester Molina et al.   Cells

Transcription factors in ferroptotic cell death

(2020) Chongshan Dai et al.   CANCER GENE THERAPY

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells

(2020) Do Hyung Kim et al.   Cell Death & Disease

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

(2020) Marcel Doerflinger et al.   IMMUNITY

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

(2020) Tigist Y. Tamir et al.   JOURNAL OF CELL SCIENCE

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

(2020) Milica Vucetic et al.   Cell Death & Disease

Structure–activity relationships of GPX4 inhibitor warheads

(2020) John K. Eaton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

Ferroptosis: the greasy side of cell death

(2019) José Pedro Friedmann-Angeli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

(2019) Constantinos Kolliopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

(2019) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death

(2019) V.E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

(2018) Hengrui Liu et al.   BIOCHEMISTRY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

(2018) Mandeep K. Gill et al.   Nature Communications

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE

(2018) Tamil S. Anthonymuthu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NUAK2 is a critical YAP target in liver cancer

(2018) Wei-Chien Yuan et al.   Nature Communications

Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer

(2017) Alexander Beatty et al.   MOLECULAR CANCER THERAPEUTICS

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

(2016) Channing Yu et al.   NATURE BIOTECHNOLOGY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma

(2011) T. Namiki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

The regulation and function of mammalian AMPK-related kinases

(2009) N. J. Bright et al.   Acta Physiologica

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Identification of a novel substrate for TNFα-induced kinase NUAK2

(2007) Hiroyuki Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS