Membrane supply and remodeling during autophagosome biogenesis

A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy

(2020) Claudia Puri et al.   DEVELOPMENTAL CELL

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid–liquid phase separation in autophagy

(2020) Nobuo N. Noda et al.   JOURNAL OF CELL BIOLOGY

The Golgi as an Assembly Line to the Autophagosome

(2020) Stefano De Tito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Organelle membrane-specific chemical labeling and dynamic imaging in living cells

(2020) Tomonori Tamura et al.   Nature Chemical Biology

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

(2020) Justyna Sawa-Makarska et al.   SCIENCE

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIβ

(2019) Delphine Judith et al.   JOURNAL OF CELL BIOLOGY

COPII vesicles contribute to autophagosomal membranes

(2019) Takayuki Shima et al.   JOURNAL OF CELL BIOLOGY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Atg11 tethers Atg9 vesicles to initiate selective autophagy

(2019) Nena Matscheko et al.   PLOS BIOLOGY

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

(2019) Zhenyuan Tang et al.   Cell Reports

Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae

(2019) David M. Hollenstein et al.   JOURNAL OF CELL SCIENCE

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

(2019) Maximilian Schütter et al.   CELL

The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis

(2018) Yan G. Zhao et al.   CURRENT BIOLOGY

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A

(2018) Claudia Puri et al.   DEVELOPMENTAL CELL

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2

(2018) Kristiane Søreng et al.   EMBO REPORTS

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores

(2018) Rubén Gómez-Sánchez et al.   JOURNAL OF CELL BIOLOGY

Genome-wide CRISPR screen identifiesTMEM41Bas a gene required for autophagosome formation

(2018) Keigo Morita et al.   JOURNAL OF CELL BIOLOGY

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

(2018) Tetsuya Kotani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

(2017) Yan G. Zhao et al.   MOLECULAR CELL

Organelle biogenesis in the endoplasmic reticulum

(2017) Amit S. Joshi et al.   NATURE CELL BIOLOGY

Atg4 plays an important role in efficient expansion of autophagic isolation membranes by cleaving lipidated Atg8 in Saccharomyces cerevisiae

(2017) Eri Hirata et al.   PLoS One

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation

(2016) Tina Garofalo et al.   Autophagy

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

(2016) Ariadna P. Velázquez et al.   JOURNAL OF CELL BIOLOGY

The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy

(2016) Yijian Rao et al.   Nature Communications

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

(2016) Eleftherios Karanasios et al.   Nature Communications

The Bif-1-Dynamin 2 membrane fission machinery regulates Atg9-containing vesicle generation at the Rab11-positive reservoirs

(2016) Yoshinori Takahashi et al.   Oncotarget

Ultrastructural relationship of the phagophore with surrounding organelles

(2015) Joanna Biazik et al.   Autophagy

Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

(2015) T. Shpilka et al.   EMBO JOURNAL

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

A Cluster of Thin Tubular Structures Mediates Transformation of the Endoplasmic Reticulum to Autophagic Isolation Membrane

(2014) T. Uemura et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

(2014) Liang Ge et al.   eLife

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

(2013) Helene Knævelsrud et al.   JOURNAL OF CELL BIOLOGY

ER exit sites are physical and functional core autophagosome biogenesis components

(2013) Martin Graef et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion

(2012) Eduardo Cebollero et al.   CURRENT BIOLOGY

Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site

(2012) Soichiro Kakuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes

(2011) Tassula Proikas-Cezanne et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

(2010) Muriel Mari et al.   JOURNAL OF CELL BIOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY