Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing

(2017) Pablo Guasp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression

(2016) Liye Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers

(2016) Masaki Takeuchi et al.   ANNALS OF THE RHEUMATIC DISEASES

The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1

(2016) Pablo Guasp et al.   Arthritis & Rheumatology

ERAP2functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

(2015) Liye Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

The immunogenetics of Behçet's disease: A comprehensive review

(2015) Masaki Takeuchi et al.   JOURNAL OF AUTOIMMUNITY

'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

(2015) Dennis McGonagle et al.   Nature Reviews Rheumatology

Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA-B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

(2015) Alejandro Sanz-Bravo et al.   Arthritis & Rheumatology

Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?

(2015) Harry Petrushkin et al.   Frontiers in Immunology

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum

(2009) A. Hearn et al.   JOURNAL OF IMMUNOLOGY

Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry

(2008) Andreas O. Weinzierl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY