Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
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Title
Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
Authors
Keywords
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Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 75, Issue 5, Pages 916-923
Publisher
BMJ
Online
2015-07-01
DOI
10.1136/annrheumdis-2014-206996
References
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Related references
Note: Only part of the references are listed.- Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis
- (2014) T J Kenna et al. GENES AND IMMUNITY
- Functionally distinctERAP1allotype combinations distinguish individuals with Ankylosing Spondylitis
- (2014) Emma Reeves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply
- (2013) Kirsty McHugh et al. ANNALS OF THE RHEUMATIC DISEASES
- Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens
- (2013) Sergey S. Seregin et al. AUTOIMMUNITY
- Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
- (2013) Adrian Cortes et al. NATURE GENETICS
- Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
- (2013) E. Zervoudi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27
- (2013) Liye Chen et al. Arthritis & Rheumatology
- Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis
- (2012) Nigil Haroon et al. ANNALS OF THE RHEUMATIC DISEASES
- Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis
- (2012) Sravan K. Payeli et al. ARTHRITIS AND RHEUMATISM
- HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class I
- (2012) J. Giles et al. JOURNAL OF IMMUNOLOGY
- Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo
- (2012) Noel García-Medel et al. MOLECULAR & CELLULAR PROTEOMICS
- Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis
- (2011) P. Bowness et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
- (2011) I. Evnouchidou et al. JOURNAL OF IMMUNOLOGY
- Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
- (2011) David M Evans et al. NATURE GENETICS
- Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
- (2011) G. Kochan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients
- (2010) S.-Y. BANG et al. JOURNAL OF RHEUMATOLOGY
- Spondylarthritis in HLA-B27/human β2-microglobulin-transgenic rats is not prevented by lack of CD8
- (2009) Joel D. Taurog et al. ARTHRITIS AND RHEUMATISM
- Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis
- (2009) W. P. Maksymowych et al. ARTHRITIS AND RHEUMATISM
- Association ofERAP1, but notIL23R, with ankylosing spondylitis in a Han Chinese population
- (2009) Stuart I. Davidson et al. ARTHRITIS AND RHEUMATISM
- Investigating the genetic association between ERAP1 and ankylosing spondylitis
- (2009) David Harvey et al. HUMAN MOLECULAR GENETICS
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