Article
Multidisciplinary Sciences
Bindu D. Paul, Marian D. Lemle, Anthony L. Komaroff, Solomon H. Snyder
Summary: The review summarizes evidence of biological abnormalities in patients with acute COVID-19 and ME/CFS, including redox imbalance, systemic inflammation, neuroinflammation, impaired ATP generation, and general hypometabolism. Although these phenomena have not been extensively studied in individuals with long COVID-19, understanding these abnormalities may lead to the development of novel therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Rebekah Maksoud, Chandi Magawa, Natalie Eaton-Fitch, Kiran Thapaliya, Sonya Marshall-Gradisnik
Summary: This systematic review aimed to evaluate potential biomarkers that could effectively differentiate ME/CFS patients from healthy controls. A total of 101 studies were included, and potential biomarkers ranged from genetic/epigenetic, immunological, metabolomics/mitochondrial/microbiome, endovascular/circulatory, neurological, ion channel, to physical dysfunction biomarkers. The findings indicated evidence of immune dysfunction in ME/CFS and the use of lymphocytes as a model to investigate the pathomechanism of the illness.
Article
Biochemistry & Molecular Biology
Irene Soffritti, Sabine Gravelsina, Maria D'Accolti, Francesca Bini, Eleonora Mazziga, Anda Vilmane, Santa Rasa-Dzelzkaleja, Zaiga Nora-Krukle, Angelika Krumina, Modra Murovska, Elisabetta Caselli
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease without diagnostic biomarkers, but there is evidence supporting a role of herpesviruses and microRNAs in its development. This study found that six out of eight selected microRNAs were differently expressed in ME/CFS patients compared to healthy controls. The levels of these microRNAs correlated with disease severity but not with pro-inflammatory cytokines or HHV-6A/6B genome levels. These results suggest that microRNAs could serve as potential biomarkers and provide insights into ME/CFS pathogenic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Rebekah Maksoud, Cassandra Balinas, Sean Holden, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik
Summary: There is currently insufficient evidence on the effectiveness of mitochondrial-targeting nutraceuticals in treating ME/CFS patients. Future well-designed studies are needed to clarify the involvement of mitochondria in the pathomechanism of ME/CFS and the impact of mitochondrial-modifying agents on illness severity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Varvara A. A. Ryabkova, Natalia Y. Y. Gavrilova, Alina A. A. Poletaeva, Alexander I. I. Pukhalenko, Irina A. A. Koshkina, Leonid P. P. Churilov, Yehuda Shoenfeld
Summary: Recent studies suggest that antibody-mediated autoimmune mechanisms may play a role in fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), specifically in relation to G protein-coupled receptors. However, the full extent of the natural antibody network and its implications in these disorders has not been fully explored.
Article
Immunology
Leonard A. Jason, Joseph Cotler, Mohammed F. Islam, Madison Sunnquist, Ben Z. Katz
Summary: This study investigated potential predictors of developing chronic fatigue syndrome (ME/CFS) in university students six months after developing infectious mononucleosis (IM). The research found that ME/CFS patients had more physical symptoms and immune irregularities before onset, but no significant differences in psychological symptoms compared to those who recovered.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Ludovic Giloteaux, Jiayin Li, Mady Hornig, W. Ian Lipkin, David Ruppert, Maureen R. R. Hanson
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained fatigue and other symptoms. This study found increased levels of extracellular vesicles (EVs) and IL2 cytokine in plasma of ME/CFS patients. The correlations between specific proteins and clinical data suggest immune response and hemostasis dysfunctions in ME/CFS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Joan Carles Domingo, Begona Cordobilla, Roser Ferrer, Marina Giralt, Jose Alegre-Martin, Jesus Castro-Marrero
Summary: ME/CFS patients exhibit alterations in oxidative stress and inflammatory markers, as well as associations between FGF21 and NT-proBNP proteins and inflammation. These findings suggest potential novel diagnostic and therapeutic targets for ME/CFS.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Medicine, Research & Experimental
Elisabeth Petter, Carmen Scheibenbogen, Peter Linz, Christian Stehning, Klaus Wirth, Titus Kuehne, Marcus Kelm
Summary: This study found that muscle sodium content in patients with ME/CFS was higher than in healthy controls before and after exercise. Furthermore, there was an inverse correlation between muscle sodium content and handgrip strength. These findings suggest that sodium overload may play a role in the pathophysiology of ME/CFS and could be a potential therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Virology
Thomas Briese, Rafal Tokarz, Lucinda Bateman, Xiaoyu Che, Cheng Guo, Komal Jain, Vishal Kapoor, Susan Levine, Mady Hornig, Alexandra Oleynik, Phenix-Lan Quan, Wai H. Wong, Brent L. Williams, Suzanne D. Vernon, Nancy G. Klimas, Daniel L. Peterson, Jose G. Montoya, Walter Ian Lipkin
Summary: This multicenter study found no consistent group-specific differences in viral nucleic acid presence in ME/CFS patients compared to healthy controls, except for a lower prevalence of anelloviruses. Future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Inigo Murga, Larraitz Aranburu, Pascual A. Gargiulo, Juan-Carlos Gomez-Esteban, Jose-Vicente Lafuente
Summary: The study reveals that patients with CFS/ME have low maintained attention and significant cognitive fatigue, with deficits in sustained attention and perception of fatigue serving as sensitive and reliable indicators for confirming or ruling out CFS/ME.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Rahel S. Konig, Werner C. Albrich, Christian R. Kahlert, Lina Samira Bahr, Ulrike Lober, Pietro Vernazza, Carmen Scheibenbogen, Sofia K. Forslund
Summary: Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating disease with unclear etiology and pathophysiology. The gut microbiome may play a role in CFS and further research is needed to explore potential diagnostic and therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lena Lutz, Johanna Rohrhofer, Sonja Zehetmayer, Michael Stingl, Eva Untersmayr
Summary: ME/CFS patients commonly exhibit abnormalities in immune parameters, including deficiencies or reduction as well as immune activation or inflammation. Common abnormalities include antibody deficiencies and low MBL levels.
Review
Pharmacology & Pharmacy
Peter L. Toogood, Daniel J. Clauw, Sameer Phadke, David Hoffman
Summary: ME/CFS is a chronic debilitating disease characterized by severe fatigue, pain, sleep disruption, and cognitive dysfunction. Current treatments focus on symptom management and addressing psychological sequelae, with ongoing efforts towards identifying effective therapies and understanding the mechanistic basis of the disease.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Wakiro Sato, Hirohiko Ono, Takaji Matsutani, Masakazu Nakamura, Isu Shin, Keiko Amano, Ryuji Suzuki, Takashi Yamamura
Summary: ME/CFS is characterized by fatigue and post-exertional malaise, with signs of neurological and autonomic dysfunction. Patients show a skewed usage of B cell receptor genes, allowing for potential differentiation from healthy controls. B cell clones utilizing certain genes are more common in patients with infection-related onset, correlating with interferon response gene expression levels.
BRAIN BEHAVIOR AND IMMUNITY
(2021)