Article
Physiology
Cong Yin, Zewei Ma, Fan Li, Chen Duan, Yexian Yuan, Canjun Zhu, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Gang Shu, Huihua Zhang, Qingyan Jiang
Summary: This study revealed that hypoxanthine (Hx) can induce skeletal muscle fatigue and impaired exercise performance in mice through increased uncoupling protein 2 (UCP2) expression, leading to decreased energy substrate storage and enhanced glycolysis. The findings may provide insight into the pathological mechanisms of clinical muscle dysfunctions like muscle fatigue and weakness caused by abnormal metabolism.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Simeon P. Cairns, Jean-Marc Renaud
Summary: During repeated intense exercise, a decrease in muscle glycogen content and disturbances in potassium (K+) concentration across muscle membranes occur simultaneously, contributing to skeletal muscle fatigue. This study aimed to investigate the interaction between elevated extracellular K+ concentration and reduced glycogen on force production. The results showed that severe depletion of glycogen led to a significant decline in force production, and the decline was exacerbated at elevated extracellular K+ concentration. Additionally, the replenishment of glucose increased both glycogen content and force production. These findings provide direct evidence of the synergistic interaction between elevated extracellular K+ concentration and reduced muscle glycogen, which may contribute to muscle fatigue by shifting the resting-force relationship towards a more negative resting membrane potential.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Simeon P. Cairns, John P. Leader, Amanda Higgins, Jean-Marc Renaud
Summary: This study investigated the factors affecting the peak force-resting membrane potential (EM) relationships in mouse muscles and found that the variability of intracellular K+ activity has a significant impact on the resting membrane potential. The study also revealed differences in the action potential overshoot-resting EM relationships between short and prolonged depolarization periods, as well as changes in force and overshoot magnitude with variations in other ion concentrations. Furthermore, the depolarization of the resting membrane potential during fatigue was found to have a significant influence on muscle force.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biology
Mariana Gomez-Barroso, Manuel A. Vargas-Vargas, Donovan J. Pena-Montes, Christian Cortes-Rojo, Alfredo Saavedra-Molina, Elizabeth Sanchez-Duarte, Alain R. Rodriguez-Orozco, Rocio Montoya-Perez
Summary: Obesity is a global public health issue that impairs the proper functioning of skeletal muscle. This study aimed to determine the most effective exercise intensity when combined with diazoxide in improving muscle tissue and metabolic capacities in obese rats. The results showed that low- and moderate-intensity exercise combined with diazoxide yielded the best results in improving muscle contraction capacity and reducing oxidative stress. These findings suggest that diazoxide and low-intensity exercise can effectively improve muscle function during obesity.
Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yizeng Li, Xiaohan Zhou, Sean X. Sun
Summary: Cells without a stiff cell wall, such as mammalian cells, must actively regulate their volume, with water flow determining cell volume variation. Proton and bicarbonate play significant roles in cell volume regulation, and cells need redundant mechanisms to maintain homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Suwen Liu, Fanna Meng, Dong Zhang, Donglin Shi, Junyi Zhou, Shuo Guo, Xuedong Chang
Summary: This study investigated the effects and mechanisms by which Lonicera caerulea berry polyphenols extract (LCBP) improved treadmill endurance in mice. The results show that LCBP reduces oxidative stress, inflammation, and apoptosis, enhances mitochondrial biosynthesis and cell proliferation, and alleviates fatigue, enhancing performance.
FRONTIERS IN NUTRITION
(2022)
Review
Physiology
Alicia A. McDonough, Robert A. Fenton
Summary: This article discusses the adaptive mechanisms involved in maintaining extracellular potassium concentration and membrane potential stability, including the signaling mechanisms in muscles and kidneys, the sensing and regulation of potassium concentration in skeletal muscles, the effects of potassium on aldosterone synthesis, and the kidney's response to changes in potassium concentration. The concept of sexual dimorphisms in renal potassium handling adaptation is introduced, and the molecular mechanisms underlying the cardiovascular benefits of a potassium-rich diet are discussed.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Nicolas Busse, Madison L. Gonzalez, Mackenzie L. Krason, Sally E. Johnson
Summary: Consumption of HMB increased the percentage of type IIA and IIA/X muscle fibers in the GM, but did not improve athletic performance in horses. Additionally, HMB supplementation did not have measurable effects on the biomechanical properties of the muscles in horses.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Clinical Neurology
Marbella Quinonez, Marino DiFranco, Fenfen Wu, Stephen C. Cannon
Summary: Recurrent episodes of weakness in periodic paralysis are caused by intermittent loss of muscle fibre excitability. Retigabine, a potassium channel opener, can prevent the episodic loss of force and enhance recovery in mouse models of HypoPP. The protection and rescue effects of retigabine are well within the therapeutic window.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena V. Gast, Laura-Marie Baier, Christian R. Meixner, Oliver Chaudry, Klaus Engelke, Michael Uder, Armin M. Nagel, Rafael Heiss
Summary: This study investigated the changes in apparent tissue potassium concentration (aTPC) in calf muscle tissue after eccentric exercise and in delayed-onset muscle soreness using potassium (K-39) magnetic resonance imaging (MRI), and compared these changes to the corresponding changes in apparent tissue sodium concentration (aTSC) measured with sodium (Na-23) MRI. The results showed that eccentric exercise leads to muscle soreness and significantly increased sodium and potassium concentrations in the muscles.
INVESTIGATIVE RADIOLOGY
(2023)
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anjali Bhat, Rafay Abu, Sankarasubramanian Jagadesan, Neetha Nanoth Vellichirammal, Ved Vasishtha Pendyala, Li Yu, Tara L. Rudebush, Chittibabu Guda, Irving H. Zucker, Vikas Kumar, Lie Gao
Summary: Exercise training improves skeletal muscle health through various adaptative pathways. Nrf2, an important antioxidant transcription factor, is crucial for the adaptative responses and beneficial effects of exercise on muscle. The study suggests that Nrf2 plays a critical role in the adaptive effects of skeletal muscle and its response to exercise training.
Article
Clinical Neurology
Daniel G. Calame, Cristina Moreno Vadillo, Seth Berger, Timothy Lotze, Marwan Shinawi, Javaher Poupak, Corina Heller, Julie Cohen, Richard Person, Aida Telegrafi, Chalongchai Phitsanuwong, Kaylene Fiala, Isabelle Thiffault, Florencia Del Viso, Dihong Zhou, Emily A. Fleming, Tomi Pastinen, Ali Fatemi, Sruthi Thomas, Samuel Pascual, Rosa J. Torres, Carmen Prior, Clara Gomez-Gonzalez, Saskia Biskup, James R. Lupski, Dragan Maric, Miguel Holmgren, Debra Regier, Sho T. Yano
Summary: Calame et al. report that genetic disorders of ATP1A3 can cause spasticity resembling cerebral palsy. They identify a genetic variant that leads to leakage of ions through the sodium-potassium pump and suggest it as a potential rare cause of spastic paraparesis. This study highlights the importance of ATP1A3 in neurological syndromes and provides insight into the molecular basis of phenotypic variability.
Article
Biochemistry & Molecular Biology
Pia Apablaza, Juan Carlos Borquez, Rodrigo Mendoza, Monica Silva, Gladys Tapia, Alejandra Espinosa, Rodrigo Troncoso, Luis A. Videla, Nevenka Juretic, Andrea del Campo
Summary: Increase in body fat leads to changes in skeletal muscle and accelerates sarcopenia, known as sarco-obesity or sarcopenic obesity. Obesity affects the skeletal muscle's ability to oxidize glucose and causes mitochondrial dysfunction. Exercise improves mitochondrial dysfunction, but the effects on the mitochondrial unfolded protein response (UPRmt) in the skeletal muscle are not well understood. This study aimed to investigate the UPRmt response to exercise in obese mice and its association with skeletal muscle function improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Clinical
Laura Froehlich, Daniel B. R. Hattesohl, Joseph Cotler, Leonard A. Jason, Carmen Scheibenbogen, Uta Behrends
Summary: The study found that perceived causal attributions by others to controllable and unstable causes in ME/CFS patients can lead to lower satisfaction with social roles and activities as well as functional status, mainly due to higher levels of perceived stigma.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Correction
Medicine, Research & Experimental
Klaus J. Wirth, Carmen Scheibenbogen, Friedemann Paul
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Benedikt Franke, Adriano Schlief, Lars Walczak, Simon Suendermann, Axel Unbehaun, Joerg Kempfert, Natalia Solowjowa, Titus Kuehne, Leonid Goubergrits
Summary: In this study, virtual treatments of transcatheter aortic valve replacement (TAVI) and surgical aortic valve replacement (SAVR) were performed, and the post-interventional hemodynamics were compared using numerical simulations. The results showed that virtual TAVI treatment had realistic hemodynamics comparable to echocardiographic measurements, and TAVI and SAVR exhibited similar hemodynamic functions in a pairwise comparison.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Stehning, Sascha Krueger, Steffen Weiss, Jouke Smink, Peter Koken, Gerhard Hindricks, Cosima Jahnke, Ingo Paetsch
Summary: The purpose of this study was to evaluate a silent MR active catheter tracking sequence for conducting catheter interventions with low acoustic noise levels. The technique modified the gradient waveforms to reduce sound pressure levels and avoid acoustic resonances. Results showed that the silent catheter tracking had a noise level within the range of a normal conversation, with equivalent signal quality and tracking accuracy as the conventional tracking. This technique improved comfort and safety and eliminated the need for MR-compatible communication equipment and background noise suppression.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biology
Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, Istvan Baczko, Christoph Knosalla, Matthieu-P Schapranow, Gunnar Dittmar, Michael Gotthardt, Martin Falcke, Vera Regitz-Zagrosek, Titus Kuehne, Philipp Mertins
Summary: Pressure overload and volume overload in heart valve diseases lead to specific forms of cardiac remodeling. Proteome profiling of human left ventricular myocardial biopsies revealed differences in protein composition compared to controls, particularly in the areas of extracellular matrix, cytoskeleton, energy metabolism, and proteostasis. Sex-specific differences were also observed. These findings provide insight into the molecular mechanisms of cardiac remodeling in patients with heart valve diseases, which could help in developing personalized treatment strategies.
LIFE SCIENCE ALLIANCE
(2023)
Article
Immunology
Otavio Cabral-Marques, Guido Moll, Rusan Catar, Beate Preuss, Lukas Bankamp, Ann-Christin Pecher, Joerg Henes, Reinhild Klein, A. S. Kamalanathan, Reza Akbarzadeh, Wieke van Oostveen, Bettina Hohberger, Matthias Endres, Bryan Koolmoes, Nivine Levarht, Rudmer Postma, Vincent van Duinen, Anton Jan van Zonneveld, Jeska de Vries-Bouwstra, Cynthia Fehres, Florian Tran, Fernando Yuri Nery do Vale, Kamilla Batista da Silva Souza, Igor Salerno Filgueiras, Lena F. Schimke, Gabriela Crispim Baiocchi, Gustavo Cabral de Miranda, Dennyson Leandro Mathias da Fonseca, Paula Paccielli Freire, Alexander M. Hackel, Hanna Grasshoff, Anja Stahle, Antje Mueller, Ralf Dechend, Xinhua Yu, Frank Petersen, Franziska Sotzny, Thomas P. Sakmar, Hans D. Ochs, Kai Schulze-Forster, Harald Heidecke, Carmen Scheibenbogen, Yehuda Shoenfeld, Gabriela Riemekasten
AUTOIMMUNITY REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Maj Samuelsson, Theda Ulrike Patricia Bartolomaeus, Harithaa Anandakumar, Irene Thowsen, Elham Nikpey, Jianhua Han, Lajos Marko, Kenneth Finne, Olav Tenstad, Johannes Eckstein, Nikolaus Berndt, Titus Kuehne, Sarah Kedziora, Ibrahim Sultan, Trude Skogstrand, Tine Karlsen, Harri Nurmi, Sofia K. Forslund, Entela Bollano, Kari Alitalo, Dominik N. Muller, Helge Wiig
Summary: This study investigates the role of VEGF-B in cardiac proteomic and metabolic adaptation in heart failure, and finds that VEGF-B TG accelerates metabolic maladaptation, leading to structural cardiomyopathy and systolic heart failure.
CARDIOVASCULAR RESEARCH
(2023)
Correction
Medicine, Research & Experimental
Elisabeth Petter, Carmen Scheibenbogen, Peter Linz, Christian Stehning, Klaus Wirth, Titus Kuehne, Marcus Kelm
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Krystallenia Paniskaki, Margarethe J. Konik, Moritz Anft, Harald Heidecke, Toni L. Meister, Stephanie Pfaender, Adalbert Krawczyk, Markus Zettler, Jasmin Jaeger, Anja Gaeckler, Sebastian Dolff, Timm H. Westhoff, Hana Rohn, Ulrik Stervbo, Carmen Scheibenbogen, Oliver Witzke, Nina Babel
Summary: Although the role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19 (PASC) is not well explored, this study found that PASC patients have a stronger CD8+ T cell response and comparable neutralizing capacity compared to controls. The persistent inflammatory response triggered by low avidity SARS-CoV-2 reactive CD8+ T cells may be responsible for the observed sequelae in PASC patients. Further studies are needed for a better understanding of the underlying immunopathogenesis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pavlo Yevtushenko, Leonid Goubergrits, Benedikt Franke, Titus Kuehne, Marie Schafstedde
Summary: This study proposes a deep learning-based approach to compute pressure and wall-shear-stress in patients with aortic stenosis. By constructing surface models of the aorta and aortic valve and performing computational fluid dynamics (CFD) simulations, an artificial neural network (ANN) was trained to accurately compute spatially resolved pressure and wall-shear-stress. The results demonstrate the potential of deep learning in computing clinically relevant hemodynamic parameters and facilitating the introduction of modelling-based treatment support into clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Elisa Stein, Cornelia Heindrich, Kirsten Wittke, Claudia Kedor, Laura Kim, Helma Freitag, Anne Krueger, Markus Toelle, Carmen Scheibenbogen
Summary: There is increasing evidence suggesting an autoimmune cause for post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), with SARS-CoV-2 being the main trigger. A small proof-of-concept study on IgG depletion using immunoadsorption (IA) showed efficacy in most patients with post-infectious ME/CFS. An ongoing observational study aims to evaluate the efficacy of IA in post-COVID-19 ME/CFS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)