Article
Nanoscience & Nanotechnology
Kaiming Shen, Li Xian Li, Haojie Li, Zongguo Xue, Jingxiang You, Yunfei Yan
Summary: The authors successfully synthesized multifunctional nanohybrids that can achieve synergistic magnetothermal-photothermal therapy (PTT) and chemotherapy. The nanohybrids demonstrate effective magnetic heating, high photothermal conversion efficiency, and the capability to encapsulate anticancer drugs.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lili Chen, Ahmed Nabil, Nanami Fujisawa, Emiho Oe, Kai Li, Mitsuhiro Ebara
Summary: A universal vector system for drug-resistant breast cancer was designed to reverse multidrug resistance, achieve thermo-chemotherapy, and enable long-term drug release. The system showed therapeutic effects and could provide personalized treatment options for different breast malignancies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Chaoyi Chen, Yuwen Chen, Lulu Zhang, Xuanhao Wang, Qingshuang Tang, Yan Luo, Yuan Wang, Cheng Ma, Xiaolong Liang
Summary: Tumor phototheranostics has great potential due to its high spatiotemporal resolution, tumor-specificity, and noninvasiveness. The authors developed a dual-targeting nanozyme with excellent photothermal stability and high photothermal conversion efficiency. The nanozyme showed superior accumulation and retention at the tumor site through biological/physical dual-targeting. The combined effect of the nanozyme improved the accuracy of both photoacoustic imaging and photothermal therapy. The tumor inhibition rate of the photo-chemodynamic therapy was 4-fold higher than that of photothermal therapy or chemodynamic therapy alone.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Jiaxin Zhang, Kaicheng Zhou, Jingbo Lin, Xianxian Yao, Dianwen Ju, Xian Zeng, Zhiqing Pang, Wuli Yang
Summary: This study investigated the relationship between chemotherapy resistance and ferroptosis in TNBC, and found that DOX-resistant TNBC cells had higher expression of Gpx4. Inducing ferroptosis by inhibiting Gpx4 expression can reduce TNBC resistance to DOX and enhance the therapeutic effect of chemotherapy. The combination of Fe3O4-PGA-DHA and Fe3O4-PASP-DOX demonstrated stronger cytotoxicity and increased intracellular accumulation of reactive oxygen species and lipid peroxides in TNBC cells. Furthermore, Fe3O4-PGA-DHA + Fe3O4-PASP-DOX triggered ferroptosis by inhibiting the PI3K/AKT/mTOR/GPX4 pathway. The study showed great potential for improving the therapeutic effect of TNBC.
Article
Pharmacology & Pharmacy
Luis Exequiel Ibarra, Simona Camorani, Lisa Agnello, Emilia Pedone, Luciano Pirone, Carlos Alberto Chesta, Rodrigo Emiliano Palacios, Monica Fedele, Laura Cerchia
Summary: Photodynamic therapy (PDT) may be a promising alternative for the treatment of breast cancer, especially for aggressive types like triple-negative breast cancer (TNBC). A recent study explored the use of conjugated polymer nanoparticles (CPNs) as photosensitizers for targeted PDT. By attaching unique 2'-Fluoropyrimidines-RNA-aptamers to the surface of CPNs, the researchers aimed to improve the selectivity of the treatment for TNBC cells. Results showed that CL4, sTN29, and sTN58 aptamers were effective in selective tumor targeting and improving PDT efficacy in TNBC cells.
Review
Biochemistry & Molecular Biology
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura
Summary: Nanoparticles, particularly silica nanoparticles, have shown significant potential in light-based nanomedicine, offering advantages for in vivo imaging and therapy, including cancer treatment. The unique structural and functional properties of silica nanoparticles make them promising in the integration of light-based diagnostics and therapeutics, leading to advancements in cancer photo-theranostics.
Article
Chemistry, Multidisciplinary
Esther Cazares-Cortes, Claire Wilhelm, Jose Efrain Perez, Ana Espinosa, Sandra Casale, Aude Michel, Ali Abou-Hassan, Christine Menager
Summary: A novel synthesis method was introduced to enhance the load of magnetic nanoparticles and gold nanorods in nanogels. Two different structures, simple cores and core-shell, were synthesized and their heating properties under alternating magnetic field or laser exposure were compared. The core-shell structure exhibited a higher heating capacity in both modalities.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jiao Zheng, Jiangchuan Sun, Jia Chen, Shenyin Zhu, Shuning Chen, Yujiao Liu, Lan Hao, Zhigang Wang, Shufang Chang
Summary: This study successfully fabricated phase-changeable core-shell nanoparticles, which have great potential for enhancing photoacoustic imaging. By combining chemotherapy and photo-sonodynamic therapy, the treatment strategy induced immunogenic cell death and significantly enhanced antitumor immunity, inhibiting the growth of ovarian cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Sumera Khizar, Eslam Elkalla, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid, Abdelhamid Elaissari
Summary: Cancer, with its high mortality rates, requires new therapeutic possibilities with enhanced benefits. Magnetic nanoparticles have shown substantial progress in cancer treatment, employing chemo-, immuno-, gene-, and radiotherapy along with hyperthermia.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Article
Chemistry, Multidisciplinary
Xiaoyu Wang, Qing Ma, Chaochao Wen, Tao Gong, Jing Li, Wenting Liang, Meining Li, Yuyao Wang, Rui Guo
Summary: The novel nano-drug carrier constructed in this study showed good stability and blood compatibility, successfully loaded a hydrophobic anti-cancer drug, and demonstrated excellent liver cancer targeting therapy efficacy.
Article
Biochemistry & Molecular Biology
Khushboo Pathania, Sangeeta P. Sah, Deepak B. Salunke, Manish Jain, Ashok Kumar Yadav, Vikramaditya G. Yadav, Sandip V. Pawar
Summary: Polymeric magnetic nanoparticles based on lignin have been developed for targeted delivery of methotrexate, showing higher efficacy in cancer diagnosis and treatment. The synthesized nanoparticles exhibit magnetic and smooth polyhedral traits with a dimension of 110-130 nm. The drug-loaded nanoparticles have high cytotoxicity in breast cancer and macrophage cell lines and exhibit sustained release of methotrexate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Mouna Selmi, Abir Salek, Mahassen Barboura, Leila Njim, Amine Trabelsi, Aida Lahmar, Nolwenn Lautram, Emilie Roger, Tarek Baati, Leila Chekir Ghedira
Summary: This study investigates the potential use of thymoquinone (TQ) from black seeds as an anticancer agent for colorectal cancer (CRC) treatment. TQ was encapsulated in lipid nanocapsules (LNCs) to enhance its specificity and cell absorption. The results showed that TQ-loaded LNCs (TQ-LNCs) were more effective than free TQ in inducing tumor cell death and reducing tumor size in colorectal cancer-bearing mice.
NANOSCALE ADVANCES
(2023)
Article
Engineering, Biomedical
Tahereh Khani, Zahra Alamzadeh, Abolfazl Sarikhani, Mahdie Mousavi, Mehri Mirrahimi, Mousa Tabei, Rasoul Irajirad, Ziaeddin Abed, Jaber Beik
Summary: In this study, researchers successfully constructed iron oxide-gold core-shell hybrid nanocomposites that can be detected through MRI and targeted towards tumors using an external magnetic field. The gold shell can respond to near-infrared light, generating localized heating for photothermal therapy. Experiments showed that this nanocomposite can effectively combine chemotherapy and photothermal therapy, resulting in superior therapeutic outcome.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Engineering, Biomedical
Feifan Zhou, Meng Wang, Teng Luo, Junle Qu, Wei R. Chen
Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.
