Article
Biochemistry & Molecular Biology
Dawn Su -Yin Sim, Sin-Yee Tang, Yun-Yee Low, Siew-Huah Lim, Toh-Seok Kam
Summary: Thirteen indole alkaloids were isolated from the leaf extract of Tabernaemontana corymbosa sample from Taiping, Perak, Malaysia. The structures of these alkaloids were determined, and a possible biogenetic pathway was proposed.
Article
Integrative & Complementary Medicine
Kun Fan, Lanchun Zhang, Bangyin Tan, Guy S. S. Njateng, Malong Qin, Ruirong Guo, Xiaojuan Huang, Cai-feng Ding, Weimin Gao, Rongping Zhang, Haofei Yu
Summary: Four unreported monoterpene indole alkaloids, named tabernaecorymines B-E, were obtained from the stem bark of a South American plant. Their structures and configurations were determined by extensive spectroscopy, quantum chemical calculations, DP4+ probability analyses, and Mo2(OAc)4-induced electronic circular dichroism experiment. These compounds showed significant antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Streptococcus dysgalactiae, and Candida albicans.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Chemistry, Medicinal
Kun Fan, Cai-Feng Ding, Shi-Yu Deng, Wen Gao, Bang-Yin Tan, Hao Wu, Ying Guo, Jing-Feng Song, Lan-Chun Zhang, Rong-Ping Zhang, Hao-Fei Yu
Summary: In this study, several alkaloids were isolated from the stem bark of Tabernaemontana corymbosa. These alkaloids showed antimicrobial activity against Staphylococcus aureus and Bacillus subtilis.
Article
Chemistry, Applied
Gertrude Foudjo Melacheu Laura, Emmanuel Mfotie Njoya, Jean-Bosco Jouda, Brussine Nadege Wakeu Kweka, Celine Djama Mbazoa, Fei Wang, Elisabeth Seguin, Jean Wandji
Summary: A new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine, was isolated from the fruits of Tabernaemontana contorta Stapf. It exhibited cytotoxic effects on human breast cancer cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sheng Li, Ling-Ling Han, Ke-Pu Huang, Ye-Han Ma, Ling-Li Guo, Yarong Guo, Xiaoqian Ran, Yong-Gang Yao, Xiao-Jiang Hao, Rongcan Luo, Yu Zhang
Summary: Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A-C (1-3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan-ibogan-type bisindole alkaloid formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were determined by HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1-3 reduce A beta 42 production and inhibit phospho-tau (Thr217) associated with Alzheimer's disease [AD] mediated pathways, indicating their potential against AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Miao Zhang, Si-Yu Du, Jie Liu, Xue Zhao, Jia-Ning Liu, Cheng-Shi Jiang, Kong-Kai Zhu, Lei Fang
Summary: Two new monoterpenoid indole alkaloids, taberibogines A and B, along with four known compounds, were isolated from the stems of Tabernaemontana bovina. The structures of these compounds were elucidated using comprehensive spectroscopic analysis and computational methods. Compounds 1-2 were found to have inhibitory effects on LPS-induced NO production in RAW 264.7 macrophages.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Lingling Han, Kepu Huang, Chen Chen, Wentao Zhu, Yehan Ma, Xiaojiang Hao, Hongping He, Yu Zhang
Summary: Two new alkaloids, Taberdines L (1) and M (2), were isolated from the twigs and leaves of Tabernaemontana divaricata, together with six known alkaloids. Taberdine L (1) is the first optically active natural member of the allo iboga class of alkaloids with an ethyl side chain in a bridgehead position. The structures, including absolute configurations, were elucidated using a combination of MS, NMR, and ECD calculation, and the cytotoxic activities of 1 and 2 against five human cancer cell lines were also evaluated.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Organic
Wen-Tao Zhu, Chen Chen, Qian Zhao, Ling-Ling Han, Min Yang, Xiao-Jiang Hao, Yu Zhang
Summary: Tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids with rare skeleton characterized by a quinuclidine moiety, were isolated from the stems of Tabernaemontana divaricata. Their structures and absolute configurations were elucidated through extensive analysis of MS, NMR, ECD, and X-ray diffraction, and a possible biogenetic pathway of 1 was also proposed.
TETRAHEDRON LETTERS
(2021)
Article
Plant Sciences
Ninh Thi Ngoc, Tran Hong Quang, Nguyen Huu Quan, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Van Thanh, Chu Hoang Ha, Nguyen Hoai Nam, Chau Van Minh
Summary: Phytochemical investigation of Tabernaemontana bovina leaves and twigs led to the isolation of 10 monoterpenoid indole alkaloids, including two new compounds. One of the new compounds, taberbovinine B, demonstrated an unusual ring C/D cleavage. Compounds 2 and 8 exhibited weak cytotoxicity against various cancer cell lines, while other compounds showed different levels of toxicity against specific cancer cells.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Applied
Xue-Wei Yan, Si-Yu Du, Xiao-Tong Wang, Kong-Kai Zhu, Lei Fang
Summary: Two new monoterpenoid indole alkaloids, named taberibogines E and F (1 and 2), together with three known ones (3-5), were isolated from the stems of Tabernaemontana bovina Lour (Apocynaceae). Their structures and absolute configurations were elucidated through NMR and HRESIMS data, NMR calculations, and DP4+ probability analyses. Compounds 1 and 2 exhibited inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Sin-Yee Tang, Min-Phin Ng, Chun-Hoe Tan, Kae-Shin Sim, Kuan-Hon Lim, Kien-Thai Yong, Yun-Yee Low, Siew-Huah Lim
Summary: Eight undescribed indole alkaloids were isolated and their structures were determined. Some of these compounds showed cytotoxicity against cancer cells.
Article
Chemistry, Physical
Yu-qi Li, Jing Cai, Jia-xin Cheng, Sheng-zhi Su, Toshihiro Akihisa, Wen-yuan Liu, Feng Feng, Jie Zhang
Summary: This study investigated the chemical constituents of Alstonia mairei and isolated twenty-four monoterpenoid indole alkaloids. Four new compounds were discovered. The structures of these compounds were characterized using various techniques. The cytotoxic activities of the isolated compounds were evaluated, and several compounds demonstrated potent inhibitory activities against A549 lung cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Guanqun Zhan, Fuxin Zhang, Kailing Yang, Tao Yang, Ruixi Zhou, Xueqing Ma, Nan Wang, Zengjun Guo
Summary: A new compound and four known compounds were isolated from Alstonia scholaris. The new compound has a unique carbon skeleton and shows potential anti-inflammatory activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Kun Fan, Lan-Chun Zhang, Wei-Yan Hu, Shi-Yu Deng, Hao Wu, Bang-Yin Tan, Rong-Ping Zhang, Cai-Feng Ding, Hao-Fei Yu
Summary: Tabernaecorymine A, a novel alkaloid compound obtained from the stem bark of Tabernaemontana corymbosa, exhibited significant antibacterial activity against Streptococcus dysgalactiae, with a better performance than the commonly used plant drug berberine.
Article
Biochemistry & Molecular Biology
Shun-Qing Chen, Jia Jia, Jing-Yao Hu, Jun Wu, Wen-Ting Sun, Mingxin Zheng, Xi Wang, Kong-Kai Zhu, Cheng-Shi Jiang, Sheng-Ping Yang, Juan Zhang, Shou-Bao Wang, You-Sheng Cai
Summary: Phytochemical investigation on the aerial parts of Tabernaemontana bufalina Lour. led to the identification of several new alkaloids and known indole alkaloids. The structures and absolute configurations of the new alkaloids were determined by spectroscopic and computational methods. Some of these alkaloids exhibited significant bioactivity, demonstrating potential for drug development.
Article
Biochemistry & Molecular Biology
Qian Zhao, Wen-Tao Zhu, Xiao Ding, Zong-Qing Huo, Paul O. Donkor, Tiwalade A. Adelakun, Xiao-Jiang Hao, Yu Zhang
Summary: Fourteen undescribed monoterpenoid indole alkaloids, voacafrines A-N, along with 7 known monoterpenoid indole alkaloids were isolated from the seeds of Voacanga africana Stapf. The structures and activities of these compounds varied, with some exhibiting acetylcholinesterase inhibitory activity and cytotoxicity against human cancer cell lines.
Article
Chemistry, Applied
Bao-Jia Yang, Juan Wang, Zheng-Quan Zeng, Xu Yang, Ai-Ying Huang, Xiao-Jiang Hao, Xiao Ding, Shun-Lin Li
Summary: Sesquiterpene lactones from Carpesium abrotanoides can induce apoptosis and protective autophagy in cancer cells, with compound 6 showing the strongest activity and ability to induce G2/M arrest and ROS accumulation. This study provides a series of compounds with potential clinical applications.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Yi-Ting Wang, Xin-Yan Long, Xiao Ding, Shi-Rui Fan, Jie-Yun Cai, Bi-Juan Yang, Xin-Fang Zhang, Rong-hua Luo, Lian Yang, Ting Ruan, Juan Ren, Chen-Xu Jing, Yong-Tang Zheng, Xiao-Jiang Hao, Duo-Zhi Chen
Summary: Novel phenanthridine derivatives targeting NPro were designed and synthesized, leading to the discovery of two potent anti-SARS-CoV-2 compounds that interact with NPro and inhibit viral replication. This study highlights the potential of targeting NPro as a strategy for developing new antiviral agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing Wu
Summary: New potential neurotoxins tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium were found to inhibit AChE in a dose-dependent manner, with reversible inhibition in a mixed-type competitive manner. These compounds may act as dual binding site AChE inhibitors, providing a theoretical basis for the development of novel pesticides.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2022)
Article
Chemistry, Applied
Chen Chen, Xiao Ding, Lingling Han, Wentao Zhu, Kepu Huang, Xiaojiang Hao, Yu Zhang
Summary: Two new monoterpenoid indole alkaloids and six known alkaloids were isolated from the methanol extract of Kopsia arborea. The structures and absolute configurations of the alkaloids were determined through various analytical methods. The cytotoxicity of these alkaloids against two human cancer cell lines was evaluated.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Yueqin Zhao, Xu Yang, Jimin Fei, Xianxiang Dong, Yinyuan Wang, Shan Yang, Xiaojiang Hao, Xiao Ding, Yuhan Zhao
Summary: In this study, three new limonoids were isolated from Walsura yunnanensis, and their cytotoxic activity against human cancer cells was evaluated. The compounds showed significant inhibition of cell growth and induced cell cycle arrest and apoptosis.
Article
Materials Science, Multidisciplinary
Wenbo Zhuang, Dafeng Hu, Xudong Zhang, Kai Xiong, Xiao Ding, Jian Lu, Yong Mao, Peng Yang, Chao Liu, Yanfen Wan
Summary: By using Ginkgo biloba extracts as a reducing agent and capping agent, we have successfully synthesized silver nanoparticles with remarkable antibacterial activities. The Ginkgo biloba extracts were found to be crucial for the preparation of uniform and monodispersed silver nanoparticles.
FRONTIERS OF MATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chen Chen, Jian-Wen Liu, Ling-Li Guo, Feng Xiong, Xiao-Qian Ran, Ya-Rong Guo, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Yu Zhang
Summary: Three novel monoterpenoid indole alkaloid dimers (kopoffines A-C) and nine known alkaloids were isolated and identified from the fruits of Kopsia arborea Blume. Kopoffines A-C exhibited significant inhibition against cyclin-dependent kinase 5 and reduced the levels of phosphorylated Tau, which are involved in the formation of neurofibrillary tangles. These findings may have implications for the development of therapeutics for related diseases.
Article
Multidisciplinary Sciences
Xiao Ding, Xu Yang, Yueqin Zhao, Yinyuan Wang, Jimin Fei, Zhenpeng Niu, Xianxiang Dong, Xuenan Wang, Biao Liu, Hongmei Li, Xiaojiang Hao, Yuhan Zhao
Summary: Lysosomal biogenesis is crucial for maintaining cellular homeostasis and defects in this process are associated with lysosome-related diseases. This study established a screening system using lysosomes to identify compounds that promote lysosomal biogenesis. One of the compounds screened, Hdj-23 from Walsura cochinchinensis, was found to induce lysosomal biogenesis through activation of TFEB/TFE3.
Article
Plant Sciences
Hui-Hui Guo, Hao-Ran Shen, Ming-Ze Tang, Ning Sheng, Xiao Ding, Yuan Lin, Jin-Lan Zhang, Jian-Dong Jiang, Tian-Le Gao, Lu-Lu Wang, Yan-Xing Han
Summary: This study revealed that the Dengzhan shengmai (DZSM) formula improves cerebral ischemic diseases by regulating the gut microbiota and their production of short-chain fatty acids (SCFAs). DZSM treatment altered the gut microbiota composition and enhanced SCFA production, leading to the inhibition of neurocyte apoptosis and the improvement of cerebral neuropathy and oxidative stress. Additionally, DZSM repaired gut barrier integrity, reduced endotoxin translocation, and attenuated neuro-inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Zhenpeng Niu, Guihua Tang, Xuenan Wang, Xu Yang, Yueqin Zhao, Yinyuan Wang, Qin Liu, Fan Zhang, Yuhan Zhao, Xiao Ding, Xiaojiang Hao
Summary: This study investigated the effect of trigonochinene E (TE) on lysosomal biogenesis and autophagy, and revealed the underlying mechanisms. The results showed that TE promotes lysosomal biogenesis and autophagy by activating transcription factors TFEB and TFE3. Mechanistically, TE regulates lysosomal biogenesis and autophagy through the PERK-calcineurin axis and IRE1 alpha-STAT3 axis. Furthermore, TE-induced autophagy protects NP cells from oxidative stress to ameliorate intervertebral disc degeneration (IVDD).
Article
Plant Sciences
Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin
Summary: In this study, two new sesquiterpenes were isolated from Laggera pterodonta, along with six known eudesmane-type sesquiterpenes, and their inhibitory effect on acetylcholinesterase (AChE) was characterized. The results showed that these compounds had a dose-dependent inhibitory effect on AChE, with compound 5 exhibiting the highest inhibitory activity. Additionally, all compounds showed certain levels of toxicity on C. elegans and displayed good ADMET properties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Xiuping Guo, Rui Li, Jinjin Cui, Chujuan Hu, Haoyang Yu, Ling Ren, Yangyang Cheng, Jiandong Jiang, Xiao Ding, Lulu Wang
Summary: This study aims to explore the anti-colorectal cancer (CRC) effect of Erigeron breviscapus injection (EBI) and its underlying mechanism. The results demonstrate that EBI significantly inhibits the proliferation of CRC cells, suppresses the migration and invasion of SW620 cells, and exerts its antitumor effect through inducing necroptosis of tumor cells. Furthermore, EBI activates the RIPK3/MLKL signaling pathway and promotes intracellular reactive oxygen species (ROS) generation, enhancing its anticancer effect.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Yan, Jie Chen, Mingyou Peng, Xiong Zhang, Enming Feng, Qindan Li, Bing Guo, Xiao Ding, Yu Zhang, Lei Tang
Summary: Ten previously undescribed sesquiterpenes and eight known compounds were isolated from Carpesium faberi. One of the compounds exhibited significant cytotoxic effects against cancer cells, inducing cell apoptosis and ROS accumulation. This study expands the knowledge of the structural diversity of sesquiterpenes and provides experimental evidence for targeting cytoprotective autophagy as a potential chemotherapeutic strategy.
Article
Chemistry, Physical
Jin-Jin Cui, Rui Li, Xiao-Lei Ma, Hao-Yang Yu, Zhi-Gang Luo, Peng Du, Ling Ren, Xiao Ding, Xiu-Ping Guo, Wen-Sheng Zheng, Jian-Dong Jiang, Yongsheng Che, Lu-Lu Wang
Summary: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial and composite, with lipid metabolism-induced lipotoxicity being one of the main risk factors. Atorvastatin (AT), the most widely prescribed lipid-lowering drug, has beneficial effects on NAFLD treatment. However, its low absorption rate in the gut and potential disruption of gut flora limit its applications. In this study, a prebiotic-based AT nanoamorphous (PANA) was developed to enhance AT efficacy against NAFLD by improving liver and gut health. Oral administration of PANA resulted in increased drug accumulation in the liver tissue and restored gut health, as indicated by reconstructed gut flora, improved intestinal immunity, barrier integrity, and inflammation. Compared to AT, PANA treatment showed significant inhibition of weight gain and fat deposition, decreased plasma lipid levels, and alleviated hepatic steatosis and liver inflammation. Transcriptome analysis suggested improved immunity and inflammation as potential mechanisms. This study presents a promising strategy for NAFLD treatment using nanotechnology and functional biomaterials in synergy.
