Article
Biochemistry & Molecular Biology
Chen Chen, Jian-Wen Liu, Ling-Li Guo, Feng Xiong, Xiao-Qian Ran, Ya-Rong Guo, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Yu Zhang
Summary: Three novel monoterpenoid indole alkaloid dimers (kopoffines A-C) and nine known alkaloids were isolated and identified from the fruits of Kopsia arborea Blume. Kopoffines A-C exhibited significant inhibition against cyclin-dependent kinase 5 and reduced the levels of phosphorylated Tau, which are involved in the formation of neurofibrillary tangles. These findings may have implications for the development of therapeutics for related diseases.
Article
Plant Sciences
Elvis Otogo N. Nang, Pierre Le Pogam, Thiery Ndong Mba, Cedric Sima Obiang, Elisabeth Mouray, Philippe Grellier, Brice Kumulungui, Pierre Champy, Mehdi A. Beniddir
Summary: A new sulfur-containing vobasane-type indole alkaloid, hemitheion (1), was isolated from the stems of Mostuea brunonis Didr. (Gelsemiaceae), along with three known compounds. Hemitheion (1) showed moderate antiplasmodial activity and no cytotoxic activity against a specific cell line.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Medicinal
Andre Nehemie Bitombo, Auguste Abouem A. Zintchem, Alex De Theodore Atchade, Norbert Mbabi Nyemeck Ii, Dominique Serge Ngono Bikobo, Christian G. Bochet, Dieudonn Emmanuel Pegnyemb
Summary: In this study, thirteen compounds, including five new carboxy-indole alkaloids and one known alkaloid, were isolated from the trunk bark of a plant in the Apocynaceae family. These compounds exhibited good in vitro antiplasmodial activities against two strains of Plasmodium falciparum. Of particular interest were penduflorines A and B, as well as tabernaemontine, which showed significant inhibitory activities against the parasites.
Review
Chemistry, Multidisciplinary
Nguyen Quang Hop, Ninh The Son
Summary: This study provides a comprehensive review of the secondary metabolites and pharmacological research of Kopsia plants. A total of 472 compounds, including 466 monoterpene alkaloids, 5 triterpenoids, and 1 sterol, were summarized. The compounds were found to exhibit various pharmacological activities such as antimicrobial and anti-inflammatory effects.
Article
Plant Sciences
Qiong Jin, Yun-Li Zhao, Ya-Ping Liu, Ruo-Song Zhang, Pei-Feng Zhu, Lan-Qin Zhao, Xu-Jie Qin, Xiao-Dong Luo
Summary: This study supported the traditional use of K. officinalis by evaluating the anti-inflammatory and analgesic effects of its purified MIAs. The results showed that the purified MIAs displayed significant anti-inflammatory effects in vitro and in vivo, providing potential bioactive compounds for further chemical modification and pharmacological investigation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Afrah E. Mohammed, Zainab H. Abdul-Hameed, Modhi O. Alotaibi, Nahed O. Bawakid, Tariq R. Sobahi, Ahmed Abdel-Lateff, Walied M. Alarif
Summary: Interest in natural compounds as drug sources declined by the end of the twentieth century, but has recently regained importance. Indole-containing compounds, such as vinblastine and vincristine, are widely used in clinical settings for various medical conditions. Monoterpene Indole Alkaloids (MIAs) are attracting attention due to their chemical diversity and biological activities, with potential as future sources of drug leads.
Article
Evolutionary Biology
Clement Cuello, Emily Amor Stander, Hans J. Jansen, Thomas Duge de Bernonville, Arnaud Lanoue, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Ron P. Dirks, Michael Krogh Jensen, Sarah Ellen O'Connor, Sebastien Besseau, Vincent Courdavault
Summary: This study reports the first genome assembly and annotation of a Voacanga species, which will contribute significantly to future comparative and evolutionary studies in MIA-producing plants.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Chemistry, Multidisciplinary
Beiling Gao, Fengjie Yao, Zhaodong Zhang, Hanfeng Ding
Summary: A bioinspired photo-Fries/imine capture cascade reaction was developed in continuous-flow mode for the rapid construction of a series of diversely functionalized 2,7-heterocycle-fused tetrahydrocarbazoles, which are core structures in strychnos and akuammiline-type monoterpene indole alkaloids. The synthetic utility of this novel method has been demonstrated through the total synthesis of (+)-alsmaphorazine C and formal synthesis of (+)-strictamine in a concise and efficient manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Guang Li, Nicolas Gaeng, Cyril Piemontesi, Qian Wang, Jieping Zhu
Summary: The enantioselective total synthesis of three monoterpene indole alkaloids was successfully achieved by introducing chirality, using MOM ether as a protective group, and employing a domino reaction to construct the indole and piperidine rings. The synthesis confirmed the absolute configuration of these natural products according to the biogenetic hypothesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Soon-Kit Wong, Joanne Soon-Yee Yeap, Chun-Hoe Tan, Kae-Shin Sim, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam
Summary: Three new bisindole alkaloids were isolated from the stem bark extract of Malayan Kopsia arborea, with arbolodinine B showing significant cytotoxic effects against various human cancer cell lines.
Review
Chemistry, Organic
Athira Parammal, Manoj Kumar, Shubham Singh, Joe Sam Xavier, Parthasarathi Subramanian
Summary: This review discusses the synthetic strategies and total synthesis methods of aspidofractinine and its analogues. Aspidofractinine is a natural product with fascinating structural features and biological activities, making its synthesis highly significant.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yinan Wu, Chang Liu, Anna Koganitsky, Franklin L. Gong, Sijin Li
Summary: Discovering natural product biosynthetic pathways of medicinal plants is challenging. In this study, a yeast-based screening method was developed to capture the protein-protein interactions (PPI) between plant enzymes. Combining this method with plant multiomics analysis, four enzyme complexes and their organized pathways were discovered from kratom. This study highlights the opportunity of leveraging post-translational regulation features to discover novel plant natural product biosynthetic pathways.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemical Research Methods
Joshua Misa, John M. Billingsley, Kanji Niwa, Rachel K. Yu, Yi Tang
Summary: This study reports the development of a yeast-based platform for high-titer production of the universal MIA precursor, strictosidine, enabling rapid access to downstream MIA natural products.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wei Cao, Yingchao Dou, Cyrille Kouklovsky, Guillaume Vincent
Summary: The first total synthesis of the monoterpene indole alkaloids ophiorrhine A is reported via a late stage bioinspired intramolecular Diels-Alder cycloaddition. The synthesis includes the construction of the indolopyridone moiety, cyclodehydration, and the desired spontaneous intramolecular Diels-Alder cycloaddition.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Audrey Mauger, Maxime Jarret, Aurelien Tap, Remi Perrin, Regis Guillot, Cyrille Kouklovsky, Vincent Gandon, Guillaume Vincent
Summary: We synthesized highly strained pentacyclic caged framework of mavacuran alkaloids and successfully achieved the concise total synthesis of C-fluorocurine, C-profluorocurine, C-mavacurine, normavacurine, 16-epi-pleiocarpamine and taberdivarine H. A strategy involving late-stage Michael addition and intermolecular 1,4-addition reactions was designed. The first total syntheses of C-profluorocurine and C-fluorocurine were achieved through dihydroxylation of C-mavacurine and a pinacol rearrangement, respectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Bao-Jia Yang, Juan Wang, Zheng-Quan Zeng, Xu Yang, Ai-Ying Huang, Xiao-Jiang Hao, Xiao Ding, Shun-Lin Li
Summary: Sesquiterpene lactones from Carpesium abrotanoides can induce apoptosis and protective autophagy in cancer cells, with compound 6 showing the strongest activity and ability to induce G2/M arrest and ROS accumulation. This study provides a series of compounds with potential clinical applications.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Yi-Ting Wang, Xin-Yan Long, Xiao Ding, Shi-Rui Fan, Jie-Yun Cai, Bi-Juan Yang, Xin-Fang Zhang, Rong-hua Luo, Lian Yang, Ting Ruan, Juan Ren, Chen-Xu Jing, Yong-Tang Zheng, Xiao-Jiang Hao, Duo-Zhi Chen
Summary: Novel phenanthridine derivatives targeting NPro were designed and synthesized, leading to the discovery of two potent anti-SARS-CoV-2 compounds that interact with NPro and inhibit viral replication. This study highlights the potential of targeting NPro as a strategy for developing new antiviral agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing Wu
Summary: New potential neurotoxins tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium were found to inhibit AChE in a dose-dependent manner, with reversible inhibition in a mixed-type competitive manner. These compounds may act as dual binding site AChE inhibitors, providing a theoretical basis for the development of novel pesticides.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2022)
Article
Chemistry, Medicinal
Yueqin Zhao, Xu Yang, Jimin Fei, Xianxiang Dong, Yinyuan Wang, Shan Yang, Xiaojiang Hao, Xiao Ding, Yuhan Zhao
Summary: In this study, three new limonoids were isolated from Walsura yunnanensis, and their cytotoxic activity against human cancer cells was evaluated. The compounds showed significant inhibition of cell growth and induced cell cycle arrest and apoptosis.
Article
Materials Science, Multidisciplinary
Wenbo Zhuang, Dafeng Hu, Xudong Zhang, Kai Xiong, Xiao Ding, Jian Lu, Yong Mao, Peng Yang, Chao Liu, Yanfen Wan
Summary: By using Ginkgo biloba extracts as a reducing agent and capping agent, we have successfully synthesized silver nanoparticles with remarkable antibacterial activities. The Ginkgo biloba extracts were found to be crucial for the preparation of uniform and monodispersed silver nanoparticles.
FRONTIERS OF MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Xiao Ding, Xu Yang, Yueqin Zhao, Yinyuan Wang, Jimin Fei, Zhenpeng Niu, Xianxiang Dong, Xuenan Wang, Biao Liu, Hongmei Li, Xiaojiang Hao, Yuhan Zhao
Summary: Lysosomal biogenesis is crucial for maintaining cellular homeostasis and defects in this process are associated with lysosome-related diseases. This study established a screening system using lysosomes to identify compounds that promote lysosomal biogenesis. One of the compounds screened, Hdj-23 from Walsura cochinchinensis, was found to induce lysosomal biogenesis through activation of TFEB/TFE3.
Article
Plant Sciences
Hui-Hui Guo, Hao-Ran Shen, Ming-Ze Tang, Ning Sheng, Xiao Ding, Yuan Lin, Jin-Lan Zhang, Jian-Dong Jiang, Tian-Le Gao, Lu-Lu Wang, Yan-Xing Han
Summary: This study revealed that the Dengzhan shengmai (DZSM) formula improves cerebral ischemic diseases by regulating the gut microbiota and their production of short-chain fatty acids (SCFAs). DZSM treatment altered the gut microbiota composition and enhanced SCFA production, leading to the inhibition of neurocyte apoptosis and the improvement of cerebral neuropathy and oxidative stress. Additionally, DZSM repaired gut barrier integrity, reduced endotoxin translocation, and attenuated neuro-inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Zhenpeng Niu, Guihua Tang, Xuenan Wang, Xu Yang, Yueqin Zhao, Yinyuan Wang, Qin Liu, Fan Zhang, Yuhan Zhao, Xiao Ding, Xiaojiang Hao
Summary: This study investigated the effect of trigonochinene E (TE) on lysosomal biogenesis and autophagy, and revealed the underlying mechanisms. The results showed that TE promotes lysosomal biogenesis and autophagy by activating transcription factors TFEB and TFE3. Mechanistically, TE regulates lysosomal biogenesis and autophagy through the PERK-calcineurin axis and IRE1 alpha-STAT3 axis. Furthermore, TE-induced autophagy protects NP cells from oxidative stress to ameliorate intervertebral disc degeneration (IVDD).
Article
Plant Sciences
Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin
Summary: In this study, two new sesquiterpenes were isolated from Laggera pterodonta, along with six known eudesmane-type sesquiterpenes, and their inhibitory effect on acetylcholinesterase (AChE) was characterized. The results showed that these compounds had a dose-dependent inhibitory effect on AChE, with compound 5 exhibiting the highest inhibitory activity. Additionally, all compounds showed certain levels of toxicity on C. elegans and displayed good ADMET properties.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Xiuping Guo, Rui Li, Jinjin Cui, Chujuan Hu, Haoyang Yu, Ling Ren, Yangyang Cheng, Jiandong Jiang, Xiao Ding, Lulu Wang
Summary: This study aims to explore the anti-colorectal cancer (CRC) effect of Erigeron breviscapus injection (EBI) and its underlying mechanism. The results demonstrate that EBI significantly inhibits the proliferation of CRC cells, suppresses the migration and invasion of SW620 cells, and exerts its antitumor effect through inducing necroptosis of tumor cells. Furthermore, EBI activates the RIPK3/MLKL signaling pathway and promotes intracellular reactive oxygen species (ROS) generation, enhancing its anticancer effect.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Yan, Jie Chen, Mingyou Peng, Xiong Zhang, Enming Feng, Qindan Li, Bing Guo, Xiao Ding, Yu Zhang, Lei Tang
Summary: Ten previously undescribed sesquiterpenes and eight known compounds were isolated from Carpesium faberi. One of the compounds exhibited significant cytotoxic effects against cancer cells, inducing cell apoptosis and ROS accumulation. This study expands the knowledge of the structural diversity of sesquiterpenes and provides experimental evidence for targeting cytoprotective autophagy as a potential chemotherapeutic strategy.
Article
Chemistry, Physical
Jin-Jin Cui, Rui Li, Xiao-Lei Ma, Hao-Yang Yu, Zhi-Gang Luo, Peng Du, Ling Ren, Xiao Ding, Xiu-Ping Guo, Wen-Sheng Zheng, Jian-Dong Jiang, Yongsheng Che, Lu-Lu Wang
Summary: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial and composite, with lipid metabolism-induced lipotoxicity being one of the main risk factors. Atorvastatin (AT), the most widely prescribed lipid-lowering drug, has beneficial effects on NAFLD treatment. However, its low absorption rate in the gut and potential disruption of gut flora limit its applications. In this study, a prebiotic-based AT nanoamorphous (PANA) was developed to enhance AT efficacy against NAFLD by improving liver and gut health. Oral administration of PANA resulted in increased drug accumulation in the liver tissue and restored gut health, as indicated by reconstructed gut flora, improved intestinal immunity, barrier integrity, and inflammation. Compared to AT, PANA treatment showed significant inhibition of weight gain and fat deposition, decreased plasma lipid levels, and alleviated hepatic steatosis and liver inflammation. Transcriptome analysis suggested improved immunity and inflammation as potential mechanisms. This study presents a promising strategy for NAFLD treatment using nanotechnology and functional biomaterials in synergy.
Article
Chemistry, Medicinal
Yan-Ni Chen, Xiao Ding, Dong-Mei Li, Qing-Yun Lu, Shuai Liu, Ying-Yao Li, Ying-Tong Di, Xin Fang, Xiao-Jiang Hao
Summary: Four new jatrophane type diterpenoids were isolated from the seeds of Euphorbia peplus, with compound 2 showing significant induction of lysosomal biogenesis and activation of the lysosomal-autophagy pathway.
NATURAL PRODUCTS AND BIOPROSPECTING
(2021)
Article
Chemistry, Organic
Yan-Ni Chen, Xiao Ding, Dong-Mei Li, Mao Sun, Lei Yang, Yu Zhang, Ying-Tong Di, Xin Fang, Xiao-Jiang Hao
Summary: Three novel jatrophane diterpenes were isolated from the seeds of Euphorbia peplus, featuring a unique tetracyclic ring system, and were found to significantly activate the lysosomal-autophagy pathway.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)