Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

(2020) Martin C. Moncrieffe et al.   STRUCTURE

BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells

(2019) Ina Georg et al.   Cellular & Molecular Immunology

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

(2019) Simon H. Jiang et al.   Nature Communications

Trans-Ethnic Mapping of BANK1 Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks

(2018) Manuel Martínez-Bueno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiation

(2018) Krystin Deason et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome

(2016) Samer Halabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation

(2016) Ying-Yu Wu et al.   PLoS One

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions

(2016) Laurens Vyncke et al.   STRUCTURE

A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway

(2015) Emine Guven-Maiorov et al.   BIOPHYSICAL JOURNAL

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

(2015) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

(2015) Emine Guven-Maiorov et al.   Scientific Reports

Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal)

(2013) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BANK1 Controls CpG-Induced IL-6 Secretion via a p38 and MNK1/2/eIF4E Translation Initiation Pathway

(2013) Y.-Y. Wu et al.   JOURNAL OF IMMUNOLOGY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

(2011) M. Ni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins

(2010) N. Treiber et al.   GENES & DEVELOPMENT

Study of functional variants of theBANK1gene in rheumatoid arthritis

(2009) Gisela Orozco et al.   ARTHRITIS AND RHEUMATISM

BANK1is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects withIRF5andSTAT4

(2009) P. Dieudé et al.   ARTHRITIS AND RHEUMATISM

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS