Cadmium activates AMPA and NMDA receptors with M3 helix cysteine substitutions

Prying open a glutamate receptor gate

(2019) Lonnie P. Wollmuth   JOURNAL OF GENERAL PHYSIOLOGY

Structural biology of glutamate receptor ion channels: towards an understanding of mechanism

(2019) Ingo H Greger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

(2018) Andrew E Fry et al.   BRAIN

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder

(2018) Ana Fernández-Marmiesse et al.   MOVEMENT DISORDERS

Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors

(2018) Michael C. Regan et al.   NEURON

Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences

(2018) Daniele Bano et al.   NEUROSCIENCE LETTERS

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

(2018) Riley Perszyk et al.   eLife

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate

(2018) Marek Ladislav et al.   Frontiers in Molecular Neuroscience

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

(2018) Farzad Jalali-Yazdi et al.   CELL

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing

(2018) Timothy J. Wilding et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

(2018) Jin-Bao Zhang et al.   Cell Reports

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers

(2016) Dong Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Human GRIN2B variants in neurodevelopmental disorders

(2016) Chun Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouth

(2016) Ya-Chi Tu et al.   Scientific Reports

Cadmium–cysteine coordination in the BK inner pore region and its structural and functional implications

(2015) Yu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate receptor pores

(2014) James E. Huettner   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

(2014) Rashek Kazi et al.   NATURE NEUROSCIENCE

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

The differential contribution of GluN1 and GluN2 to the gating operation of the NMDA receptor channel

(2014) Ya-Chi Tu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles

(2013) Melany N. Lopez et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors

(2013) C. L. Salussolia et al.   JOURNAL OF NEUROSCIENCE

Probing the activation sequence of NMDA receptors with lurcher mutations

(2012) Swetha E. Murthy et al.   JOURNAL OF GENERAL PHYSIOLOGY

Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain

(2012) A. J. Gleichman et al.   JOURNAL OF NEUROSCIENCE

Labeling of Specific Cysteines in Proteins Using Reversible Metal Protection

(2011) Michael C. Puljung et al.   BIOPHYSICAL JOURNAL

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines

(2011) Laetitia Mony et al.   EMBO JOURNAL

Distinct Functional Roles of Subunits within the Heteromeric Kainate Receptor

(2011) J. L. Fisher et al.   JOURNAL OF NEUROSCIENCE

The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits

(2011) Alexander C. Jackson et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

The Transmembrane Domain C of AMPA Receptors is Critically Involved in Receptor Function and Modulation

(2010) Jan Terhag et al.   Frontiers in Molecular Neuroscience

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids

(2008) Timothy J. Wilding et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Activation Gate and Gating Mechanism of the NMDA Receptor

(2008) H.-R. Chang et al.   JOURNAL OF NEUROSCIENCE

The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor

(2008) M. L. Blanke et al.   MOLECULAR PHARMACOLOGY