Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria

(2018) Andrew E Fry et al.   BRAIN

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder

(2018) Ana Fernández-Marmiesse et al.   MOVEMENT DISORDERS

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

(2018) Riley Perszyk et al.   eLife

The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate

(2018) Marek Ladislav et al.   Frontiers in Molecular Neuroscience

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

(2017) Edward C. Twomey et al.   NATURE

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

(2017) Tzu-Ming Wang et al.   NEUROPHARMACOLOGY

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

(2017) Maria V. Yelshanskaya et al.   Scientific Reports

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers

(2016) Dong Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Structural basis of kainate subtype glutamate receptor desensitization

(2016) Joel R. Meyerson et al.   NATURE

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

(2016) Maria V. Yelshanskaya et al.   NEURON

Physiopathology of kainate receptors in epilepsy

(2015) Valérie Crépel et al.   CURRENT OPINION IN PHARMACOLOGY

GRID2 mutations span from congenital to mild adult-onset cerebellar ataxia

(2015) M. Coutelier et al.   NEUROLOGY

Cadmium–cysteine coordination in the BK inner pore region and its structural and functional implications

(2015) Yu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate receptor pores

(2014) James E. Huettner   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Radial symmetry in a chimeric glutamate receptor pore

(2014) Timothy J. Wilding et al.   Nature Communications

Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles

(2013) Melany N. Lopez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kainate Receptors in Health and Disease

(2013) Juan Lerma et al.   NEURON

Probing the activation sequence of NMDA receptors with lurcher mutations

(2012) Swetha E. Murthy et al.   JOURNAL OF GENERAL PHYSIOLOGY

Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface

(2012) Julien Veran et al.   NEURON

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors

(2012) Morgane Riou et al.   PLoS One

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

(2012) Andreas Reiner et al.   Cell Reports

Labeling of Specific Cysteines in Proteins Using Reversible Metal Protection

(2011) Michael C. Puljung et al.   BIOPHYSICAL JOURNAL

Arrangement of Subunits in Functional NMDA Receptors

(2011) C. L. Salussolia et al.   JOURNAL OF NEUROSCIENCE

Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis

(2010) Timothy J. Wilding et al.   JOURNAL OF GENERAL PHYSIOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor That Contributes to Channel Gating

(2008) Kristin Rule Gleitsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids

(2008) Timothy J. Wilding et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Activation Gate and Gating Mechanism of the NMDA Receptor

(2008) H.-R. Chang et al.   JOURNAL OF NEUROSCIENCE

pH-Dependent Inhibition of Kainate Receptors by Zinc

(2008) D. D. Mott et al.   JOURNAL OF NEUROSCIENCE

A conserved salt bridge critical for GABAA receptor function and loop C dynamics

(2008) S. P. Venkatachalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA