The action of a BK channel opener

Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021

(2020) Michael E. Rockman et al.   JOURNAL OF GENERAL PHYSIOLOGY

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

(2019) Marcus Schewe et al.   SCIENCE

Molecular structures of the human Slo1 K+ channel in complex with β4

(2019) Xiao Tao et al.   eLife

Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase

(2018) Sandra Frankenreiter et al.   CARDIOVASCULAR RESEARCH

Hydrophobic gating in BK channels

(2018) Zhiguang Jia et al.   Nature Communications

A voltage-dependent K+channel in the lysosome is required for refilling lysosomal Ca2+stores

(2017) Wuyang Wang et al.   JOURNAL OF CELL BIOLOGY

Structural basis for gating the high-conductance Ca2+-activated K+ channel

(2016) Richard K. Hite et al.   NATURE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

BKCachannel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells

(2016) Monali Wakle-Prabagaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: role of BK channels and cholinergic neurotransmission

(2015) Vítor S. Fernandes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

(2015) Qi Cao et al.   DEVELOPMENTAL CELL

Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology

(2014) Georgi V. Petkov   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

(2014) Boxing Li et al.   NATURE NEUROSCIENCE

Myelinated Ah-type trigeminal ganglion neurons in female rats: neuroexcitability, chemosensitivity to histamine, and potential clinical impact

(2014) Hua Liu et al.   NEUROSCIENCE LETTERS

KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury

(2014) Ewa Soltysinska et al.   PLoS One

Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury

(2013) Gudrun H Borchert et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MaxiK channel and cell signalling

(2013) Ligia Toro et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Properties of Slo1 K+ channels with and without the gating ring

(2013) G. Budelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of pharmacological activation of BK channels

(2012) G. Gessner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

(2011) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiological relevance of apical large-conductance Ca2+-activated potassium channels in pancreatic duct epithelial cells

(2010) V. Venglovecz et al.   GUT

Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino–neuronal pathway

(2010) H. Wulf-Johansson et al.   NEUROSCIENCE

BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle

(2009) Jeffrey J. Layne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Energetic performance is improved by specific activation of K+ fluxes through KCa channels in heart mitochondria

(2009) Miguel A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats

(2009) A Kun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Closed-channel block of BK potassium channels by bbTBA requires partial activation

(2009) Qiong-Yao Tang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo

(2009) Bo Hjorth Bentzen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Molecular mechanisms of BK channel activation

(2008) J. Cui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of big conductance Ca2+-activated K+ channels (BK) protects the heart against ischemia–reperfusion injury

(2008) Bo Hjorth Bentzen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY