GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

Photodynamic therapy guidelines for the management of oral leucoplakia

(2019) Qianming Chen et al.   International Journal of Oral Science

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

(2019) Victoria Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease

(2018) Michal Hershfinkel   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

First GPCR-directed antibody passes approval milestone

(2018) Elie Dolgin   NATURE REVIEWS DRUG DISCOVERY

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

(2018) Daniel Martin et al.   Nature Communications

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The zinc sensing receptor ZnR GPR39 in health and disease

(2017) Michal Hershfinkel   Frontiers in Bioscience-Landmark

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

C-MYC and BCL-2 mediate YAP-regulated tumorigenesis in OSCC

(2017) Xiyan Chen et al.   Oncotarget

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Neuron navigator 2 overexpression indicates poor prognosis of colorectal cancer and promotes invasion through the SSH1L/cofilin-1 pathway

(2015) Fengbo Tan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

(2015) S. E. Hiemer et al.   MOLECULAR CANCER RESEARCH

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The ZnR/GPR39 Interacts With the CaSR to Enhance Signaling in Prostate and Salivary Epithelia

(2013) Hila Asraf et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integration of molecular targeted therapy with radiation in head and neck cancer

(2013) Yu Du et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma

(2011) Fajun Xie et al.   BMC CANCER

Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody

(2011) Jonathan K. Fleming et al.   JOURNAL OF MOLECULAR BIOLOGY

A Novel Molecular Signature Identified by Systems Genetics Approach Predicts Prognosis in Oral Squamous Cell Carcinoma

(2011) Chien-Hua Peng et al.   PLoS One

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Transcriptomic dissection of tongue squamous cell carcinoma

(2008) Hui Ye et al.   BMC GENOMICS

Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells

(2008) Noga Dubi et al.   CARCINOGENESIS