Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn’s Disease

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

(2019) María Martínez-López et al.   IMMUNITY

Correlation between endoscopic and histological validated scoring indices in Crohn’s disease

(2019) Wenbin Gong et al.   DIGESTIVE AND LIVER DISEASE

Preliminary exploration of the potential of spliceosome‐associated protein 130 for predicting disease severity in Crohn's disease

(2019) Wenbin Gong et al.   Annals of the New York Academy of Sciences

Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome–Mediated IL-1β in Mice

(2018) Jong-Won Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis

(2018) Nicole Ranson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Crohn's disease

(2017) Joana Torres et al.   LANCET

Crohn Disease: Epidemiology, Diagnosis, and Management

(2017) Joseph D. Feuerstein et al.   MAYO CLINIC PROCEEDINGS

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

The C-Type Lectin Mincle: Clues for a Role in Crohn’s Disease Adjuvant Reaction

(2017) Anje A. te Velde   Frontiers in Immunology

Sensing Lipids with Mincle: Structure and Function

(2017) Spencer J. Williams   Frontiers in Immunology

IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

(2016) Hao Zhou et al.   HEPATOLOGY

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

Mincle Signaling Promotes Con A Hepatitis

(2016) Stephanie H. Greco et al.   JOURNAL OF IMMUNOLOGY

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

(2016) R K Boyapati et al.   Mucosal Immunology

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

Mincle Signaling in the Innate Immune Response after Traumatic Brain Injury

(2015) Juan Carlos de Rivero Vaccari et al.   JOURNAL OF NEUROTRAUMA

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

(2015) Yue He et al.   STROKE

IBD and health-related quality of life — Discovering the true impact

(2014) Sanna Lönnfors et al.   Journal of Crohns & Colitis

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

(2012) Mamdouh A K Sedhom et al.   GUT

Sensing necrosis with Mincle

(2008) Gordon D Brown   NATURE IMMUNOLOGY

Mincle is an ITAM-coupled activating receptor that senses damaged cells

(2008) Sho Yamasaki et al.   NATURE IMMUNOLOGY