Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Rebecca A. Symons, Fabio Colella, Fraser L. Collins, Alexandra J. Rafipay, Karolina Kania, Jessica J. McClure, Nathan White, Iain Cunningham, Sadaf Ashraf, Elizabeth Hay, Kevin S. Mackenzie, Kenneth A. Howard, Anna H. K. Riemen, Antonio Manzo, Susan M. Clark, Anke J. Roelofs, Cosimo De Bari
Summary: The IL-6-Yap-Snail signaling axis plays a critical role in the pathogenic transformation of synovial fibroblasts in inflammatory arthritis, where Yap activation is regulated by IL-6 and SF invasiveness is influenced by Yap.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Xin Li, Yimeng Lei, Ziyu Gao, Gang Wu, Wei Gao, Liping Xia, Jing Lu, Hui Shen
Summary: IL-34 promotes proliferation and inhibits apoptosis of FLSs in RA, with IL-17 inhibitor reducing the effects of IL-34, indicating the significant role of IL-17 in this process. IL-34 also induces the expression of inflammatory cytokines and angiogenic factors in RA-FLSs.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Vesa-Petteri Kouri, Juri Olkkonen, Katariina Nurmi, Nitai Peled, Mari Ainola, Jami Mandelin, Dan C. Nordstrom, Kari K. Eklund
Summary: IL-17A and TNF synergistically induce proinflammatory mediators in synovial fibroblasts, and ELF3 plays an important role in this process. These findings provide new insights into the pathogenesis of chronic arthritis and suggest ELF3 as a potential therapeutic target.
Review
Medicine, General & Internal
Yang Si, Jiwei Zhang, Shisan Bao, Steven G. G. Wise, Yuli Wang, Yanfang Zhang, Yuhong Tang
Summary: Hepatocellular carcinoma (HCC) has a high mortality and morbidity rate, and its development is influenced by multiple factors such as viral infection, alcoholism, and non-alcoholic fatty liver disease. Dysregulated host immunity plays a significant role in tumorigenesis among susceptible individuals. IL-32 and IL-34, key cytokines involved in chronic inflammatory conditions, also contribute to the development of HCC by influencing inflammation. This review provides insights into the latest research on IL-32 and IL-34 in HCC, highlighting their potential as therapeutic targets in precision medicine.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Hematology
Nainita Roy, Christopher Y. Park
Summary: In this article, Xie et al(1) discovered a new role for interleukin 34 (IL-34) in promoting hematopoietic progenitor and myeloid leukemia differentiation through binding to the previously unrecognized IL-34 receptor, TREM2.
Article
Multidisciplinary Sciences
Fuqing Hu, Da Song, Yumeng Yan, Changsheng Huang, Chentao Shen, Jingqin Lan, Yaqi Chen, Anyi Liu, Qi Wu, Li Sun, Feng Xu, Fayong Hu, Lisheng Chen, Xuelai Luo, Yongdong Feng, Shengyou Huang, Junbo Hu, Guihua Wang
Summary: IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator BECN1, leading to chemotherapeutic resistance. BECN1 Y333 phosphorylation is crucial for BECN1 activation and IL-6-induced autophagy by regulating PI3KC3 complex formation. Combination treatment targeting the IL-6/JAK2/BECN1 signaling pathway may be a potential strategy for CRC therapy.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Florent Carsuzaa, Emilie Bequignon, Matthieu Bainaud, Jean-Francois Jegou, Xavier Dufour, Jean-Claude Lecron, Laure Favot
Summary: This study investigated the mechanisms of action of Oncostatin M (OSM) in the fibrosis process associated with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). The results showed that OSM can counteract the profibrotic effects of TGF-beta 1 and IL-4 by inhibiting nuclear translocation of Smad3. Therefore, OSM could be an efficient tool to protect against fibrosis in CRSwNP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Feng Wang, Hong Sung Min, Haojie Shan, Fuli Yin, Chaolai Jiang, Yang Zong, Xin Ma, Yiwei Lin, Zubin Zhou, Xiaowei Yu
Summary: IL-34 promotes osteoclast differentiation and activation, aggravating steroid-induced osteonecrosis of the femoral head (ONFH). IL-34 expression is up-regulated in patients with ONFH and femoral heads of ONFH mice, while IL-34 deficient mice show resistance to ONFH induction. IL-34 works in coordination with M-CSF to promote osteoclastogenesis and activates ERK, STAT3, and non-canonical NF-kappa B pathways.
Article
Biochemistry & Molecular Biology
Carolina Duarte, Juliet Akkaoui, Anny Ho, Christopher Garcia, Chiaki Yamada, Alexandru Movila
Summary: The Spike protein of SARS-CoV-2 virus can increase the production of SASP markers in macrophages, with varying effects based on age and gender, as shown in a mouse model of M-CSF and IL-34-differentiated macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Rheumatology
Tamas Nemeth, Gyorgy Nagy, Thomas Pap
Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Immunology
Jane Falconer, Valentina Pucino, Sally A. Clayton, Jennifer L. Marshall, Sabrina Raizada, Holly Adams, Andrew Philp, Andrew R. Clark, Andrew Filer, Karim Raza, Stephen P. Young, Christopher D. Buckley
Summary: The study aims to identify metabolic changes occurring early in inflammatory disease pathogenesis to support sustained cellular activation. Findings show differences in FLS metabolism persisting after ex vivo culture, indicating disease-associated metabolic changes are long-lasting, termed as 'metabolic memory'. This study suggests the potential to modulate mitochondrial function at sites of inflammation to restore cell metabotypes, with implications for treatment of RA and related inflammatory conditions where fibroblasts play a role.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)