Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

(2015) Dmitry Borkin et al.   CANCER CELL

Structure-based discovery of an immunomodulatory inhibitor of TLR1–TLR2 heterodimerization from a natural product-like database

(2015) Zhangfeng Zhong et al.   CHEMICAL COMMUNICATIONS

Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential

(2015) Juan Bayo et al.   Future Medicinal Chemistry

Natural products as a source of drug leads to overcome drug resistance

(2015) Lynn L Silver   Future Microbiology

Biochemical Reconstitution and Phylogenetic Comparison of Human SET1 Family Core Complexes Involved in Histone Methylation

(2015) Stephen A. Shinsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silico identification of natural product inhibitors of JAK2

(2015) Hai-Jing Zhong et al.   METHODS

Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme

(2015) Hai-Jing Zhong et al.   METHODS

Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library

(2014) Dik-Lung Ma et al.   CHEMICAL COMMUNICATIONS

Challenges and opportunities in targeting the menin–MLL interaction

(2014) Tomasz Cierpicki et al.   Future Medicinal Chemistry

Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

(2014) Tomasz Cierpicki et al.   IMMUNOLOGICAL REVIEWS

The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma

(2014) Shu-Bin Gao et al.   JOURNAL OF HEPATOLOGY

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

(2014) Shihan He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

(2014) L-J Liu et al.   Cell Death & Disease

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

(2013) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments

(2012) Kazumasa Ohashi et al.   BIOTECHNIQUES

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

(2012) A. Shi et al.   BLOOD

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

(2012) Jolanta Grembecka et al.   Nature Chemical Biology

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and Perspective

(2008) Xinjiang Wu et al.   CURRENT MOLECULAR MEDICINE