期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 34, 页码 5788-5791出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc01079b
关键词
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资金
- Hong Kong Baptist University [FRG2/14-15/004, FRG2/15-16/002]
- Health and Medical Research Fund [HMRF/14130522]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- Inter-institutional Collaborative Research Scheme [RC-ICRS/15-16/02A]
- National Natural Science Foundation of China [21575121]
- Guangdong Province Natural Science Foundation [2015A030313816]
- Hong Kong Baptist University Century Club Sponsorship Scheme
- Interdisciplinary Research Matching Scheme [RC-IRMS/14-15/06]
- Science and Technology Development Fund, Macao SAR [103/2012/A3]
- University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS, MRG044/LCH/2015/ICMS]
- Australian Research Council [DP160101682]
The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
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