A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

Ring Expansion of 3-Oxetanone-Derived Spirocycles: Facile Synthesis of Saturated Nitrogen Heterocycles

(2013) Stefan A. Ruider et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds

(2013) Paul MacLellan et al.   CHEMICAL COMMUNICATIONS

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Enantiodivergent Synthetic Entry to the Quinolizidine Alkaloid Lasubine II

(2011) Nemai Saha et al.   ORGANIC LETTERS

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

N-Heterocycle construction via cyclic sulfamidates. Applications in synthesis

(2010) John F. Bower et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy

(2010) Alan Rolfe et al.   ORGANIC LETTERS

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of 3,4-Dihydroisoquinolines by a C(sp3)H Activation/Electrocyclization Strategy: Total Synthesis of Coralydine

(2008) Manon Chaumontet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry

(2008) Alan H. Lipkus et al.   JOURNAL OF ORGANIC CHEMISTRY

A Flexible Route to Chiral 2-endo-Substituted 9-Oxabispidines and Their Application in the Enantioselective Oxidation of Secondary Alcohols

(2008) Matthias Breuning et al.   JOURNAL OF ORGANIC CHEMISTRY