Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition

Diastereo- and Enantioselective Copper(I)-Catalyzed Intermolecular [3+2] Cycloaddition of Azomethine Ylides with β-Trifluoromethyl β,β-Disubstituted Enones

(2016) Zhan-Ming Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

(2016) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Domino Oxa-Michael/1,6-Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds

(2016) Kun Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric synthesis of cyclopentanes bearing four contiguous stereocenters via an NHC-catalyzed Michael/Michael/esterification domino reaction

(2016) Tao Shu et al.   CHEMICAL COMMUNICATIONS

Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3′-oxindole] framework

(2016) Yue-Ming Wang et al.   CHEMICAL COMMUNICATIONS

Stereoselective Ag-Catalyzed 1,3-Dipolar Cycloaddition of Activated Trifluoromethyl-Substituted Azomethine Ylides

(2016) Alberto Ponce et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes withN-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5′-Trifluoromethyl-spiro[pyrrolidin-3,2′-oxindoles]

(2015) Quantao Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

The Diarylprolinol Silyl Ethers: Ten Years After

(2015) Bjarke S. Donslund et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

(2015) Mingxia Ma et al.   CHEMICAL COMMUNICATIONS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Enantiopure trans-2,5-Disubstituted Trifluoromethylpyrrolidines and (2S,5R)-5-Trifluoromethylproline

(2015) Hodney Lubin et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Fully Substituted Cyclopentane-Oxindoles through an Organocatalytic Triple Michael Domino Reaction

(2014) Liang-Hua Zou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Construction of Spiro[indoline-3,2′-pyrrole] Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions Using Allenes as Equivalents of Alkynes

(2014) Cong-Shuai Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives

(2013) Xiaofei Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Synthesis of Tetracyclic Pyridocarbazole Derivatives by Using a Diels-Alder/aza-Michael/Aldol Condensation Domino Reaction

(2013) Dieter Enders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of an MIF-1 analogue containing enantiopure ( S )-α-trifluoromethyl-proline and biological evaluation on nociception

(2013) Ibtissem Jlalia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of Trifluoromethyl Analogues of Polyhydroxypyrrolidines

(2013) Rama K. Khangarot et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Highly Diastereoselective and Enantioselective Synthesis of Polysubstituted Pyrrolidines via an Organocatalytic Dynamic Kinetic Resolution Cascade

(2013) Tao Cheng et al.   ORGANIC LETTERS

Recent advances in organocatalytic asymmetric synthesis of polysubstituted pyrrolidines

(2013) Man-Yi Han et al.   TETRAHEDRON LETTERS

Quadruple Domino Organocatalysis: An Asymmetric Aza-Michael/Michael/Michael/Aldol Reaction Sequence Leading to Tetracyclic Indole Structures with Six Stereocenters

(2012) Dieter Enders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor

(2012) Gaël Tran et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organo-SOMO Cycloadditions: A Catalytic Approach to Complex Pyrrolidines from Olefins and Aldehydes

(2012) Nathan T. Jui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereoselective Synthesis of CF3-Substituted, Epoxide-Fused Heterocycles with β-(Trifluoromethyl)vinylsulfonium Salts

(2012) Sven P. Fritz et al.   ORGANIC LETTERS

Cu(I)/DTBM-BIPHEP-catalyzed exo-selective 1,3-dipolar cycloaddition of azomethine ylides with cis-trifluorocrotonate for asymmetric construction of trifluoromethylated pyrrolidines

(2012) Qing-Hua Li et al.   TETRAHEDRON LETTERS

Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles

(2011) Jie Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Diarylprolinol Silyl Ether System: A General Organocatalyst

(2011) Kim L. Jensen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chiral Silver Amide Catalyst for the [3+2] Cycloaddition of α-Amino Esters to Olefins

(2011) Yasuhiro Yamashita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic One-Pot Three-Component Catalytic Asymmetric Transformation by Combination of Hydrogen-Bond-Donating and Amine Catalysts

(2011) Shuangzheng Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric construction of trifluoromethylated pyrrolidines via Cu(i)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates

(2011) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

(2011) Albert Moyano et al.   CHEMICAL REVIEWS

(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry

(2011) Andrii V. Bezdudny et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Binaphthol-Derived Bisphosphoric Acids Serve as Efficient Organocatalysts for Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides to Electron-Deficient Olefins

(2011) Long He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Ynones with Azomethine Ylides

(2011) Feng Shi et al.   ORGANIC LETTERS

Asymmetric Synthesis of Polyfunctionalized Pyrrolidines via a Thiourea Catalyzed Domino Mannich/Aza-Michael Reaction

(2010) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in the Development of MMPIs and APNIs Based on the Pyrrolidine Platforms

(2010) X. Li et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Highly enantio- and diastereoselective organocatalytic cascade aza-Michael–Michael reactions: a direct method for the synthesis of trisubstituted chiral pyrrolidines

(2008) Hao Li et al.   CHEMICAL COMMUNICATIONS

Reaction Control in the Organocatalytic Asymmetric One-Pot, Three-Component Reaction of Aldehydes, Diethyl α-Aminomalonate and Nitroalkenes: Toward Diversity-Oriented Synthesis

(2008) Yan-Kai Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Concise access to enantiopure (S)- and (R)-α-trifluoromethyl pyroglutamic acids from ethyl trifluoropyruvate-based chiral CF3-oxazolidines (Fox)

(2008) Grégory Chaume et al.   JOURNAL OF FLUORINE CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Iodocyclization of Chiral CF3-Allylmorpholinones: A Versatile Strategy for the Synthesis of Enantiopure α-Tfm-Prolines and α-Tfm-Dihydroxyprolines

(2008) Caroline Caupène et al.   ORGANIC LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS