RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models

Limited AT1 Receptor Internalization Is a Novel Mechanism Underlying Sustained Vasoconstriction Induced by AT1 Receptor Autoantibody From Preeclampsia

(2019) Jingwei Bian et al.   Journal of the American Heart Association

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen

(2019) Estrellita Uijl et al.   HYPERTENSION

Diabetes Mellitus in Pregnancy Leads to Growth Restriction and Epigenetic Modification of theSrebf2Gene in Rat FetusesNovelty and Significance

(2018) Michaela Golic et al.   HYPERTENSION

Reversal of siRNA-mediated gene silencing in vivo

(2018) Ivan Zlatev et al.   NATURE BIOTECHNOLOGY

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

The role of Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor (AT1-AA) in Pathophysiology of Preeclampsia

(2018) Nathan Campbell et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain

(2017) Stefanie Endesfelder et al.   NEUROTOXICITY RESEARCH

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male MiceNovelty and Significance

(2016) Chia-Hua Wu et al.   HYPERTENSION

Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury

(2016) Daniela Hoeber et al.   Oxidative Medicine and Cellular Longevity

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for PreeclampsiaNovelty and Significance

(2015) Lukasz Przybyl et al.   HYPERTENSION

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

(2015) Emily P. Thi et al.   NATURE

Less-Tight versus Tight Control of Hypertension in Pregnancy

(2015) Laura A. Magee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concise Review: Understanding the Renal Progenitor Cell Niche In Vivo to Recapitulate Nephrogenesis In Vitro

(2015) Chiara Mari et al.   Stem Cells Translational Medicine

Signaling during Kidney Development

(2015) Mirja Krause et al.   Cells

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monocytes and Macrophages in Pregnancy and Pre-Eclampsia

(2014) Marijke M. Faas et al.   Frontiers in Immunology

Endothelin-1, Oxidative Stress, and Endogenous Angiotensin II

(2013) Justin Brewer et al.   HYPERTENSION

Angiogenic Factors in Diagnosis, Management, and Research in Preeclampsia

(2013) Sarosh Rana et al.   HYPERTENSION

Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension

(2013) Jeffrey Olearczyk et al.   HYPERTENSION RESEARCH

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypertension in Pregnancy

(2013)   OBSTETRICS AND GYNECOLOGY

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

(2012) Jing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The placental renin–angiotensin system and oxidative stress in pre-eclampsia

(2012) H.D. Mistry et al.   PLACENTA

Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals

(2011) Andrew D. Johnson et al.   HYPERTENSION

Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats

(2011) Katrin Wenzel et al.   HYPERTENSION

Renin Angiotensin Signaling in Normal Pregnancy and Preeclampsia

(2011) Roxanna A. Irani et al.   SEMINARS IN NEPHROLOGY

An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure

(2010) Connie C. W. Hsia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy

(2010) Lydia Hering et al.   HYPERTENSION

Autoantibody-Mediated Angiotensin Receptor Activation Contributes to Preeclampsia Through Tumor Necrosis Factor-α Signaling

(2010) Roxanna A. Irani et al.   HYPERTENSION

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Novel therapeutic targets for hypertension

(2010) Ludovit Paulis et al.   Nature Reviews Cardiology

Immune cells in the placental bed

(2009) Judith N. Bulmer et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

(2008) Cissy C Zhou et al.   NATURE MEDICINE