Inhibition of Interleukin‐6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice

Bazedoxifene exhibits growth suppressive activity by Targeting IL-6/GP130/STAT3 Signaling in Hepatocellular Carcinoma

(2019) Haiyan Ma et al.   CANCER SCIENCE

Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice

(2019) Daniel A. Richards et al.   Scientific Reports

Cardioprotective Role of Myeloid-Derived Suppressor Cells in Heart Failure

(2018) Ling Zhou et al.   CIRCULATION

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Independent of left ventricular mass, circulating inflammatory markers rather than pressure load are associated with concentric left ventricular remodelling

(2018) Gavin R. Norton et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection

(2018) Tao Zeng et al.   CANADIAN JOURNAL OF CARDIOLOGY

Epigallocatechin gallate attenuates overload-induced cardiac ECM remodeling via restoring T cell homeostasis

(2017) Yongsheng Han et al.   Molecular Medicine Reports

Myocardial stress and autophagy: mechanisms and potential therapies

(2017) Lea M. D. Delbridge et al.   Nature Reviews Cardiology

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

(2017) Hui Xiao et al.   PLoS One

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Chronic Heart Failure and Inflammation

(2016) Sarah A. Dick et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN JOURNAL OF HEART FAILURE

Distinct changes of myocyte autophagy during myocardial hypertrophy and heart failure: association with oxidative stress

(2016) Bao Li et al.   EXPERIMENTAL PHYSIOLOGY

The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1–7)-Mas axes in pressure overload-induced cardiac remodeling in male mice

(2016) Xingxu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart failure and kidney dysfunction: epidemiology, mechanisms and management

(2016) Joerg C. Schefold et al.   Nature Reviews Nephrology

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

Mechanotransduction in Cardiac Hypertrophy and Failure

(2015) R. C. Lyon et al.   CIRCULATION RESEARCH

Innate Immunity and the Failing Heart

(2015) Douglas L. Mann   CIRCULATION RESEARCH

The varying faces of IL-6: From cardiac protection to cardiac failure

(2015) Jillian A. Fontes et al.   CYTOKINE

Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells

(2015) Xiaopeng Yuan et al.   EXPERIMENTAL CELL RESEARCH

Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice

(2015) Linjie Si et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

A Contemporary Appraisal of the Heart Failure Epidemic in Olmsted County, Minnesota, 2000 to 2010

(2015) Yariv Gerber et al.   JAMA Internal Medicine

Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface

(2014) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

(2014) Wei Gong et al.   Frontiers of Medicine

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice

(2013) Wilbur Y. W. Lew et al.   PLoS One

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia

(2012) Sebastiano Sciarretta et al.   CIRCULATION

Worldwide risk factors for heart failure: A systematic review and pooled analysis

(2012) Shahab Khatibzadeh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice

(2012) N Chin Lai et al.   LABORATORY INVESTIGATION

Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Autophagy and p62 in Cardiac Proteinopathy

(2011) Qingwen Zheng et al.   CIRCULATION RESEARCH

C-Reactive Protein Overexpression Exacerbates Pressure Overload–Induced Cardiac Remodeling Through Enhanced Inflammatory Response

(2011) Toshiyuki Nagai et al.   HYPERTENSION

The Primary Benefits of Angiotensin-Converting Enzyme Inhibition on Cardiac Remodeling Occur During Sleep Time in Murine Pressure Overload Hypertrophy

(2011) Tami A. Martino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats

(2010) Giselle C. Meléndez et al.   HYPERTENSION

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

Transverse Aortic Constriction in Mice

(2010) Angela C. deAlmeida et al.   Jove-Journal of Visualized Experiments

Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis

(2009) Jee-Young Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Molecular regulation of cardiac hypertrophy

(2008) Sean P. Barry et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY