Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells

(2012) Xiaodong Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Omega-3 Fatty Acids Prevent Pressure Overload–Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts

(2011) Jinghai Chen et al.   CIRCULATION

β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure

(2011) Li Ni et al.   PLoS One

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

(2009) Peter Pokreisz et al.   CIRCULATION

Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload

(2009) Takahiro Nagayama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway

(2008) S. Hsu et al.   CARDIOVASCULAR RESEARCH

Cyclic GMP/Protein Kinase G Phosphorylation of Smad3 Blocks Transforming Growth Factor-β–Induced Nuclear Smad Translocation

(2008) Iain L.O. Buxton et al.   CIRCULATION RESEARCH

Tackling heart failure in the twenty-first century

(2008) James O. Mudd et al.   NATURE

Atrial Natriuretic Peptide Inhibits Transforming Growth Factor β–Induced Smad Signaling and Myofibroblast Transformation in Mouse Cardiac Fibroblasts

(2007) Peng Li et al.   CIRCULATION RESEARCH