A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?

(2020) Noah C Peeri et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Emergence of a novel coronavirus causing respiratory illness from Wuhan, China

(2020) Julian W. Tang et al.   JOURNAL OF INFECTION

The reproductive number of COVID-19 is higher compared to SARS coronavirus

(2020) Ying Liu et al.   JOURNAL OF TRAVEL MEDICINE

COVID-19: what is next for public health?

(2020) David L Heymann et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19: combining antiviral and anti-inflammatory treatments

(2020) Justin Stebbing et al.   LANCET INFECTIOUS DISEASES

Emergence of a novel human coronavirus threatening human health

(2020) Leo L. M. Poon et al.   NATURE MEDICINE

Coronavirus Disease 2019 (COVID-19): A Perspective from China

(2020) Zi Yue Zu et al.   RADIOLOGY

Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies

(2020) Syed Faraz Ahmed et al.   Viruses-Basel

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Teicoplanin: an alternative drug for the treatment of COVID-19?

(2020) Sophie Alexandra Baron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

(2019) Javier A. Jaimes et al.   Jove-Journal of Visualized Experiments

Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding

(2019) Jimmy Chun Cheong Lai et al.   Emerging Microbes & Infections

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

(2019) Ruben J. G. Hulswit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza virus infection as well as immunization with DNA encoding haemagglutinin protein induces potent antibody-dependent phagocytosis (ADP) and monocyte infection-enhancing responses in macaques

(2019) Gerrit Koopman et al.   JOURNAL OF GENERAL VIROLOGY

Significant inhibition of re-emerged and emerging swine enteric coronavirus in vitro using the multiple shRNA expression vector

(2019) Kai Li et al.   ANTIVIRAL RESEARCH

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

(2019) Yingying Cong et al.   JOURNAL OF VIROLOGY

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

(2019) David I Bernstein et al.   LANCET INFECTIOUS DISEASES

Experimental Approaches to Identify Host Factors Important for Influenza Virus

(2019) Grace A. Schaack et al.   Cold Spring Harbor Perspectives in Medicine

Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV): Revision of screening strategies urgently needed

(2018) Hala Amer et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1

(2018) Pawel Zmora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function

(2018) Javier A. Jaimes et al.   VIROLOGY

Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host

(2018) Jian Zheng et al.   Current Opinion in Virology

Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization

(2018) Hannah Kleine-Weber et al.   JOURNAL OF VIROLOGY

Promising approaches for the treatment and prevention of viral respiratory illnesses

(2017) Nikolaos G. Papadopoulos et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies

(2017) Chunhua Li et al.   JOURNAL OF VIROLOGY

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system

(2017) Jun Xu et al.   Molecular Medicine Reports

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

(2017) Xiao C. Li et al.   PHARMACOLOGICAL RESEARCH

MERS-CoV spike protein: a key target for antivirals

(2016) Lanying Du et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Immunogenicity and protective efficacy of recombinant fusion proteins containing spike protein of infectious bronchitis virus and hemagglutinin of H3N2 influenza virus in chickens

(2016) Lijuan Yin et al.   VIRUS RESEARCH

Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak

(2016) Yuri Kim et al.   mBio

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion

(2015) Wentao Li et al.   JOURNAL OF VIROLOGY

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder

(2015) WooJin Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions

(2013) N van Doremalen et al.   Eurosurveillance

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

(2013) Veronika Lodermeyer et al.   Retrovirology

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

(2012) Anna-Winona Struck et al.   ANTIVIRAL RESEARCH

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured Cells

(2009) Y. Yamada et al.   JOURNAL OF VIROLOGY

Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2

(2008) A. C. Mathewson et al.   JOURNAL OF GENERAL VIROLOGY