Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation

Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity

(2019) Xiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET

(2019) Dong-Fei Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau interacts with the C-terminal region of α-synuclein, promoting formation of toxic aggregates with distinct molecular conformations

(2019) Anvesh K. R. Dasari et al.   BIOCHEMISTRY

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

(2019) Balvindar Singh et al.   ACTA NEUROPATHOLOGICA

Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy

(2019) Elena Espa et al.   MOVEMENT DISORDERS

Better Together: A Hybrid Amyloid Signals Necroptosis

(2018) Dan Li et al.   CELL

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau

(2018) Karishma Bhasne et al.   JOURNAL OF MOLECULAR BIOLOGY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

(2018) Sue-Ann Mok et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease

(2018) Gucci Jijuan Gu et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization

(2018) Zhenying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of serine 305 in tau inhibits aggregation

(2018) Kevin H. Strang et al.   NEUROSCIENCE LETTERS

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

(2017) David J Irwin et al.   LANCET NEUROLOGY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated

(2016) Kanae Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Versatile Structures of α-Synuclein

(2016) Chuchu Wang et al.   Frontiers in Molecular Neuroscience

Phosphorylation induces distinct alpha-synuclein strain formation

(2016) Meng-Rong Ma et al.   Scientific Reports

Pathological Interface Between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

(2015) Urmi Sengupta et al.   BIOLOGICAL PSYCHIATRY

Alpha-synuclein and tau: teammates in neurodegeneration?

(2014) Simon Moussaud et al.   Molecular Neurodegeneration

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Confluence of α-Synuclein, Tau, and β-Amyloid Pathologies in Dementia With Lewy Bodies

(2013) Martí Colom-Cadena et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

(2013) Adrien W. Schmid et al.   MOLECULAR & CELLULAR PROTEOMICS

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

(2011) Katerina Levitan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau

(2011) Stefan Bibow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY