Scorpion venoms and associated toxins as anticancer agents: update on their application and mechanism of action

Control of metabolism by p53 – Cancer and beyond

(2018) Christiaan F. Labuschagne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein

(2018) Maryam Abbastabar et al.   DNA REPAIR

Effects of Brazilian scorpion venoms on the central nervous system

(2018) Ana Leonor Abrahão Nencioni et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Apoptotic Caspases: Multiple or Mistaken Identities?

(2018) Kate McArthur et al.   TRENDS IN CELL BIOLOGY

North American scorpion species of public health importance with a reappraisal of historical epidemiology

(2018) Edmundo González-Santillán et al.   ACTA TROPICA

Venom as therapeutic weapon to combat dreadful diseases of 21st century: A systematic review on cancer, TB, and HIV/AIDS

(2018) Ameer Khusro et al.   MICROBIAL PATHOGENESIS

Immunotherapy in Glioblastoma

(2018) Jessica A. Wilcox et al.   World Neurosurgery

Impact of intracellular ion channels on cancer development and progression

(2016) Roberta Peruzzo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Glioblastoma multiforme targeted therapy: The Chlorotoxin story

(2016) Or Cohen-Inbar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

An efficient approach to clone and express active Neopladine 2, an anticancer peptide from Tityus discrepans scorpion venom

(2016) Felipe Olvera et al.   PROCESS BIOCHEMISTRY

Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential

(2016) Tengfei Xu et al.   Scientific Reports

In vitro and in vivo antitumor effects of the Egyptian scorpion Androctonus amoreuxi venom in an Ehrlich ascites tumor model

(2016) Mohamed L. Salem et al.   SpringerPlus

BmKn-2 Scorpion Venom Peptide for Killing Oral Cancer Cells by Apoptosis

(2015) Pirut Tong-ngam et al.   Asian Pacific Journal of Cancer Prevention

Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration

(2015) Shihao Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting ion channels for cancer therapy by repurposing the approved drugs

(2015) Vijay Pralhad Kale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Immunopathologic effects of scorpion venom on hepato-renal tissues: Involvement of lipid derived inflammatory mediators

(2015) Amal Lamraoui et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Targeting extrinsic apoptosis in cancer: Challenges and opportunities

(2015) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Scorpion venom components as potential candidates for drug development

(2015) Ernesto Ortiz et al.   TOXICON

In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines

(2015) ABDULRAHMAN KHAZIM AL-ASMARI et al.   Oncology Letters

Inhibition Effects of Scorpion Venom Extracts (Buthus matensii karsch) on the Growth of Human Breast Cancer MCF-7 cells

(2014) W Li et al.   African Journal of Traditional Complementary and Alternative Medicines

Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

(2014) Kimberly M. Stroka et al.   CELL

Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases proliferation and migration of C6 glioma cells

(2014) Yuejun Fu et al.   CYTOTECHNOLOGY

Scorpion venoms as a potential source of novel cancer therapeutic compounds

(2014) Jian Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cationicity-Enhanced Analogues of the Antimicrobial Peptides, AcrAP1 and AcrAP2, from the Venom of the Scorpion, Androctonus crassicauda, Display Potent Growth Modulation Effects on Human Cancer Cell Lines

(2014) Qiang Du et al.   International Journal of Biological Sciences

Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells

(2014) Teerakul Arpornsuwan et al.   International Journal of Peptide Research and Therapeutics

Sj7170, a Unique Dual-function Peptide with a Specific α-Chymotrypsin Inhibitory Activity and a Potent Tumor-activating Effect from Scorpion Venom

(2014) Yu Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells

(2014) Martha Pedraza Escalona et al.   Journal of Proteomics

Mitochondrial ion channels as oncological targets

(2014) L Leanza et al.   ONCOGENE

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

(2014) A. P. Andersen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ion channels in cancer: future perspectives and clinical potential

(2014) F. Lang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cl- and K+ channels and their role in primary brain tumour biology

(2014) K. L. Turner et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ion channels and transporters in the development of drug resistance in cancer cells

(2014) E. K. Hoffmann et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The anti-proliferative effects and mechanisms of low molecular weight scorpion BmK venom peptides on human hepatoma and cervical carcinoma cells in vitro

(2014) WEILING LI et al.   Oncology Letters

Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities

(2013) Xiaoxiao Guo et al.   BIOCHIMIE

Mauriporin, a Novel Cationic α-Helical Peptide with Selective Cytotoxic Activity Against Prostate Cancer Cell Lines from the Venom of the Scorpion Androctonus mauritanicus

(2013) Ammar Almaaytah et al.   International Journal of Peptide Research and Therapeutics

The scorpion in Spanish folk medicine: A review of traditional remedies for stings and its use as a therapeutic resource

(2013) José A. González et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resistance of cervical adenocarcinoma cells (HeLa) to venom from the scorpion Centruroides limpidus limpidus

(2013) José María Contreras-Ortiz et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562

(2013) Jian Ma et al.   PLoS One

Lipid-derived inflammatory mediators: Their role in pathogenesis of scorpion envenomation

(2013) S. Adi-Bessalem et al.   TOXICON

Scorpion venom components that affect ion-channels function

(2013) V. Quintero-Hernández et al.   TOXICON

Cardiac involvement and its complications about three cases of severe scorpion envenomation

(2013) B. Aboumaâd et al.   TOXICON

Intracellular ion channels and cancer

(2013) Luigi Leanza et al.   Frontiers in Physiology

Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

(2012) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumour suppressor genes in chemotherapeutic drug response

(2012) Dulcie Lai et al.   BIOSCIENCE REPORTS

Hypoxia-induced Up-regulation of Aquaporin-1 Protein in Prostate Cancer Cells in a p38-dependent Manner

(2012) Lu Tie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High-grade Glioma Motility Reduced by Genetic Knockdown of KCC3

(2012) Kenneth B. Gagnon   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Scorpion venom component III inhibits cell proliferation by modulating NF-κB activation in human leukemia cells

(2012) XIANGFENG SONG et al.   Experimental and Therapeutic Medicine

Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells

(2012) YU GU et al.   Oncology Letters

Emerging options for the management of scorpion stings

(2012) Jean-Philippe Chippaux   Drug Design Development and Therapy

Scorpion (Androctonus crassicauda) venom limits growth of transformed cells (SH-SY5Y and MCF-7) by cytotoxicity and cell cycle arrest

(2011) Jamil Zargan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Preparation and In Vitro Evaluation of 131I-BmK CT as a Glioma-Targeted Agent

(2010) Jinhua Zhao et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line

(2010) Gina D’Suze et al.   TOXICON

Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: Through mitochondrial pathway and inhibition of heat shock proteins

(2009) Shubho Das Gupta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice

(2009) Ana Claudia Paneque Peres et al.   TOXICON

Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response

(2008) Sonia Adi-Bessalem et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Edematogenic Activity of Scorpion Venoms from the Buthidae Family and the Role of Platelet-Activating Factor and Nitric Oxide in Paw Edema Induced by Tityus Venoms

(2008) D. N. Severino et al.   INFLAMMATION