Article
Oncology
Li Liao, Yin -Ling Zhang, Ling Deng, Chao Chen, Xiao-Yan Ma, Lisa Andriani, Shao-Ying Yang, Shu-Yuan Hu, Fang-Lin Zhang, Zhi-Min Shao, Da-Qiang Li
Summary: PPP1R14B is upregulated in TNBC and promotes cancer progression and paclitaxel resistance through maintaining the phosphorylation and stability of STMN1. It is a potential therapeutic target for TNBC.
Article
Biochemistry & Molecular Biology
Michal Ostrowka, Anna Duda-Madej, Filip Pietluch, Pawel Mackiewicz, Przemyslaw Gagat
Summary: Lactoferrin, an iron-binding glycoprotein, has multiple functions including antimicrobial, antiviral, antifungal, anticancer, antioxidant, and immunomodulatory activities. This study generated three novel human lactoferrin fragments, which were predicted to have antimicrobial activity. However, none of the new fragments showed antimicrobial properties, except for hLF 1-11, which was lethal against Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yong-Liang Li, Long-Jia Yan, Hui-Xiong Chen, Ban-Kang Ruan, Pascal Dao, Zhi-Yun Du, Chang-Zhi Dong, Bernard Meunier
Summary: Vascular endothelial growth factor receptors (VEGFRs) have shown promise as therapeutic targets for recurrent glioblastomas (GBM). However, current anti-VEGF treatments have limitations, leading to non-responsiveness and tumor progression. This study focuses on the development of FGFR1 inhibitors that potently inhibit FGFR1 kinase activities, displaying anti-angiogenic, anti-tumor growth, and anti-invasion effects. These findings highlight the significance of FGFR1 signaling in GBM and suggest the potential of targeting FGFR1 as a novel anti-angiogenic strategy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gerciane Silva de Oliveira, Amanda Maria de Souza Nascimento, Anna Beatriz Santana Luz, Ana Julia Felipe Camelo Aguiar, Mayara Santa Rosa Lima, Lidia Leonize Rodrigues Matias, Isabel Rodriguez Amado, Thais Souza Passos, Karla Suzane Florentino da Silva Chaves Damasceno, Norberto de Kassio Vieira Monteiro, Susana Margarida Gomes Moreira, Lorenzo Pastrana, Ana Heloneida de Araujo Morais
Summary: This study evaluated the genotoxicity and antibacterial effects of trypsin inhibitor isolated from tamarind seeds (TTI) and its derived peptides. The results showed that TTI did not cause genotoxicity and TTIp 56/287 had a stronger interaction with Gram-positive bacteria membrane. Molecular dynamics analysis revealed the important role of arginine and threonine residues in the antibacterial activity of TTI and its derived peptides.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Cell Biology
Salman Ahmed, Muhammad Mohtasheemul Hasan, Michael Aschner, Hamed Mirzaei, Waqas Alam, Syed Muhammad Mukarram Shah, Haroon Khan
Summary: Glioblastoma multiforme is the most common primary malignant brain tumor, with poor prognosis and limited treatment options. Marine peptides have shown potential as safe therapeutic agents for glioblastoma through various pathways.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Camila Ramalho Bonturi, Bruno Ramos Salu, Camila Nimri Bonazza, Rita de Cassia Sinigaglia, Tiago Rodrigues, Miryam Paola Alvarez-Flores, Ana Marisa Chudzinski-Tavassi, Maria Luiza Vilela Oliva
Summary: Cell adhesion and migration are crucial for cancer progression. This study reveals the anti-cancer properties of Enterolobium contortisiliquum trypsin inhibitor (EcTI) in melanoma cells, inhibiting their proliferation, migration, invasion, and adhesion. EcTI triggers apoptosis, increases reactive oxygen species production, and disrupts mitochondrial function, offering potential as a therapeutic drug for melanoma treatment.
Article
Chemistry, Medicinal
Patrick Gonschorek, Alessandro Zorzi, Tamara Maric, Mathilde Le Jeune, Mischa Schuettel, Mathilde Montagnon, Rebeca Gomez-Ojea, Denis Patrick Vollmar, Chantal Whitfield, Luc Reymond, Vanessa Carle, Hitesh Verma, Oliver Schilling, Alain Hovnanian, Christian Heinis
Summary: In this study, selective and high-affinity inhibitors of KLK5 and KLK7 were identified using phage display. The stability and half-life of the inhibitors were improved by eliminating proteaseprone sites and conjugating them to an albumin-binding peptide. These inhibitors were shown to reach the target KLKs in mouse epidermis and have the potential to control deregulated protease activity in Netherton syndrome.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Ruobing Guan, Shaoru Hu, Xiang Li, Shiheng An, Xuexia Miao, Haichao Li
Summary: This study focused on the transcriptome sequence of the Asian corn borer and identified several protease and protease inhibitor genes. One novel serine protease inhibitor gene, ACB-TIL, was found to be involved in the insect's immune response to Gram-negative bacteria and viruses. This gene has the potential to be a target for pest control.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ranim El Baba, Sebastien Pasquereau, Sandy Haidar Ahmad, Franck Monnien, Marine Abad, Frederic Bibeau, Georges Herbein
Summary: Mounting evidence suggests that human cytomegalovirus (HCMV) may be an oncogenic virus, as it has been found in malignant gliomas. The oncogenic proteins EZH2 and Myc have been correlated with glioma grade. This study provides experimental evidence that HCMV can reprogram mature human astrocytes into CMV-Elicited Glioblastoma Cells (CEGBCs) with glioblastoma-like traits. These CEGBCs exhibit spheroid formation and invasiveness, suggesting a role for HCMV in the transformation and invasion processes. Clinical strains of HCMV isolated from glioblastoma patients transformed human astrocytes into CEGBCs with upregulated EZH2 and Myc. These findings highlight the importance of Myc and EZH2 in the pathophysiology of astrocytic brain tumors and suggest new therapeutic strategies.
Article
Medicine, Research & Experimental
Tatsuya Suwa, Minoru Kobayashi, Yukari Shirai, Jin-Min Nam, Yoshiaki Tabuchi, Norihiko Takeda, Shusuke Akamatsu, Osamu Ogawa, Takashi Mizowaki, Ester M. Hammond, Hiroshi Harada
Summary: The study identified SPINK1 as a protein induced under hypoxic conditions in tumors, which enhances radioresistance of cancer cells and accelerates tumor growth after radiotherapy. This suggests SPINK1 could be a target for radiosensitization and a plasma marker for predicting tumor hypoxia.
Article
Pharmacology & Pharmacy
Jasmin Gattringer, Olivier Eteme Ndogo, Bernhard Retzl, Carina Ebermann, Christian W. Gruber, Roland Hellinger
Summary: This study identified novel cyclotides from African plants, including alca 1 and alca 2, which showed inhibitory effects on the activity of the human protease POP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ming Ji, Dongjie Wang, Songwen Lin, Chunyang Wang, Ling Li, Zhihui Zhang, Jing Jin, Deyu Wu, Yi Dong, Heng Xu, Duo Lu, Xiaoguang Chen
Summary: XH30, a potent PI3K inhibitor, exhibits anti-tumor activity against human glioblastoma by inhibiting cell proliferation, blocking PI3K pathway activation, and suppressing tumor cell migration.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Organic
Arun K. Ghosh, Monika Yadav
Summary: Nirmatrelvir (Paxlovid) is an FDA approved drug that targets SARS-COV-2 3CLprotease. An optically active synthesis of nirmatrelvir was developed to avoid epimerization, which is a crucial step in the synthesis process. A ZnCl2-mediated direct N-trifluroacetylation method was utilized to overcome the epimerization problem and successfully synthesize nirmatrelvir derivatives without significant epimerization.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Callum Stewart-McGuinness, Christopher Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt
Summary: This study used proteomics approaches to comprehensively analyze proteases and protease inhibitors in human skin, identifying various types of P/PIs and their distribution in normal and diseased skin. The results showed significant differences in the characteristics of P/PIs in different skin disease groups, suggesting a potential role of P/PIs in disease progression and providing important information for further research on the pathogenesis of skin diseases.
Article
Biochemistry & Molecular Biology
Wei Hong, Yange Lang, Tian Li, Zhengyang Zeng, Yu Song, Yingliang Wu, Wenxin Li, Zhijian Cao
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Shi-Song Han, Ze-Yong Li, Jing-Yi Zhu, Kai Han, Zheng-Yang Zeng, Wei Hong, Wen-Xin Li, Hui-Zhen Jia, Yun Liu, Ren-Xi Zhuo, Xian-Zheng Zhang
Article
Food Science & Technology
Zhengyang Zeng, Qian Zhang, Wei Hong, Yingqiu Xie, Yun Liu, Wenxin Li, Yingliang Wu, Zhijian Cao
Article
Medicine, Research & Experimental
Zhengyang Zeng, Shisong Han, Wei Hong, Yange Lang, Fangfang Li, Yongxiang Liu, Zeyong Li, Yingliang Wu, Wenxin Li, Xianzheng Zhang, Zhijian Cao
MOLECULAR THERAPY-NUCLEIC ACIDS
(2016)
Article
Neurosciences
Zemin Wang, Rosemary J. Jackson, Wei Hong, Walter M. Taylor, Grant T. Corbett, Arturo Moreno, Wen Liu, Shaomin Li, Matthew P. Frosch, Inna Slutsky, Tracy L. Young-Pearse, Tara L. Spires-Jones, Dominic M. Walsh
JOURNAL OF NEUROSCIENCE
(2017)
Article
Clinical Neurology
Wei Hong, Zemin Wang, Wen Liu, Tiernan T. O'Malley, Ming Jin, Michael Willem, Christian Haass, Matthew P. Frosch, Dominic M. Walsh
ACTA NEUROPATHOLOGICA
(2018)
Article
Multidisciplinary Sciences
Ming Jin, Brian O'Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O'Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
NATURE COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Zhengyang Zeng, Runhong Zhang, Wei Hong, Yuting Cheng, Huijuan Wang, Yange Lang, Zhenglin Ji, Yingliang Wu, Wenxin Li, Youli Xie, Zhijian Cao
Article
Neurosciences
Tomas Ondrejcak, Igor Klyubin, Grant T. Corbett, Graham Fraser, Wei Hong, Alexandra J. Mably, Matthew Gardener, Jayne Hammersley, Michael S. Perkinton, Andrew Billinton, Dominic M. Walsh, Michael J. Rowan
JOURNAL OF NEUROSCIENCE
(2018)
Article
Clinical Neurology
Gunnar Brinkmalm, Wei Hong, Zemin Wang, Wen Liu, Tiernan T. O'Malley, Xin Sun, Matthew P. Frosch, Dennis J. Selkoe, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Dominic M. Walsh
Article
Neurosciences
David Mengel, Wei Hong, Grant T. Corbett, Wen Liu, Alexandra DeSousa, Laura Solforosi, Cheng Fang, Matthew P. Frosch, John Collinge, David A. Harris, Dominic M. Walsh
Article
Multidisciplinary Sciences
Benedikt Zott, Manuel M. Simon, Wei Hong, Felix Unger, Hsing-Jung Chen-Engerer, Matthew P. Frosch, Bert Sakmann, Dominic M. Walsh, Arthur Konnerth
Article
Clinical Neurology
Grant T. Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C. Hall, Lai Ding, Alexandra DeSousa, Matthew P. Frosch, John Collinge, David A. Harris, Michael S. Perkinton, Tara L. Spires-Jones, Tracy L. Young-Pearse, Andrew Billinton, Dominic M. Walsh
ACTA NEUROPATHOLOGICA
(2020)
Article
Biochemistry & Molecular Biology
Sipian Li, Shuwen Sunchen, Dangui He, Chenhu Qin, Zheng Zuo, Bingzheng Shen, Zhijian Cao, Wei Hong, Lixia Miao
Article
Biochemistry & Molecular Biology
Eun Hee Ahn, Kecheng Lei, Seong Su Kang, Zhi-Hao Wang, Xia Liu, Wei Hong, Yu Tian Wang, Laura E. Edgington-Mitchell, Lingjing Jin, Keqiang Ye
Summary: Inhibition of complexes II or III in the mitochondrial electron transport chain leads to motor disorders and PD pathologies in mice, triggering dopaminergic neuronal cell death and activating the C/EBP beta/AEP pathway. Deletion of the SDHD gene in Substantia Nigra also results in ROS and PD pathologies, demonstrating that mitochondrial ETC inactivation plays a key role in PD pathogenesis.
MOLECULAR PSYCHIATRY
(2021)