Active-Site-Directed Inhibitors of Prolyl Oligopeptidase Abolish Its Conformational Dynamics

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

(2015) Mari H. Savolainen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

(2014) Mari H. Savolainen et al.   NEUROBIOLOGY OF DISEASE

Crystal Structures of Trypanosoma brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes

(2013) Peter Canning et al.   PLoS One

Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase

(2012) Karol Kaszuba et al.   BIOCHIMIE

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

(2012) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

From protein interaction networks to novel therapeutic strategies

(2012) Samira Jaeger et al.   IUBMB LIFE

15N Relaxation NMR Studies of Prolyl Oligopeptidase, an 80 kDa Enzyme, Reveal a Pre-existing Equilibrium between Different Conformational States

(2011) Nessim Kichik et al.   CHEMBIOCHEM

Induced-fit Mechanism for Prolyl Endopeptidase

(2010) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of proteins and complexes using small-angle X-ray solution scattering

(2010) Haydyn D.T. Mertens et al.   JOURNAL OF STRUCTURAL BIOLOGY

Proteins in dynamic equilibrium

(2010) Pau Bernadó et al.   NATURE

Small-angle scattering for structural biology-Expanding the frontier while avoiding the pitfalls

(2010) David A. Jacques et al.   PROTEIN SCIENCE

Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR

(2010) T. L. Religa et al.   SCIENCE

Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity

(2009) Elena Di Daniel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Prolyl oligopeptidase stimulates the aggregation of α-synuclein

(2008) Inger Brandt et al.   PEPTIDES