Article
Pharmacology & Pharmacy
Qing Hu, Xiaoling Fu, Yanping Su, Yanfang Wang, Sihuan Gao, Xiaoqin Wang, Ying Xu, Changxi Yu
Summary: This study successfully improved the bioavailability of Koumine (KME) by optimizing the synthesis of inclusion complexes, resulting in enhanced solubility and intestinal absorption efficiency.
Article
Biochemistry & Molecular Biology
Wanrong Song, Xizhao Chen, Chongshan Dai, Degui Lin, Xuelin Pang, Di Zhang, Gang Liu, Yipeng Jin, Jiahao Lin
Summary: This study successfully improved the bioavailability of curcumin by preparing different complexes of the compound, which is significant for its application.
Article
Pharmacology & Pharmacy
Yixing Lu, Liuye Yang, Wanying Zhang, Shiting Xie, Feifei Zhao, Xianfeng Peng, Zonghua Qin, Dongping Zeng, Zhenling Zeng
Summary: In this study, we prepared an IBG/HP-beta-CD complex and found that it significantly improved the aqueous solubility, pharmaceutical properties, absorption, and bioavailability of IBG.
Article
Pharmacology & Pharmacy
Risako Onodera, Tomohiro Hayashi, Keiichi Motoyama, Kohei Tahara, Hirofumi Takeuchi
Summary: This study investigated the mechanism underlying the improved absorption of Silymarin (SLM) after oral administration by using nanoparticles and freeze-drying. The results showed that the SLM nanoparticles prepared using high-pressure crystallization method exhibited a narrow size distribution. Furthermore, the freeze-dried SLM nanoparticles with HP-beta-CyD showed improved solubility, wettability, and membrane permeability, leading to enhanced oral absorption of SLM.
Article
Food Science & Technology
Christian Hundshammer, Christiane Schon, Madoka Kimura, Takahiro Furune, Keiji Terao, Dana Elgeti, Rachela Mohr
Summary: The study showed that ?-cyclodextrin enhances the oral and metabolic bioavailability of curcumin and tetrahydrocurcumin, respectively, with a threefold increase in serum tetrahydrocurcumin compared to curcumin after just 4 weeks. This is likely due to improved uptake of cyclodextrin complexed curcumin, as demonstrated by in vitro studies, metabolic turnover, and the prolonged plasma half-life of tetrahydrocurcumin.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Pharmacology & Pharmacy
Ljubisa Nikolic, Maja Urosevic, Vesna Nikolic, Ivana Gajic, Ana Dinic, Vojkan Miljkovic, Srdan Rakic, Sanja Dokic, Jelena Kesic, Snezana Ilic-Stojanovic, Goran Nikolic
Summary: This paper presents the formulation of a complex of curcumin with 2-hydroxypropyl-beta-cyclodextrin in a thermosensitive hydrogel, characterized by various techniques. The release rate of curcumin from the gel complex formulation is constant over time, and a formulation that can release curcumin for more than 60 days can be designed. The Korsmeyer-Peppas model best describes the release of curcumin from the gel formulation, with diffusion as the mechanism of release.
Article
Chemistry, Physical
Roberto Zagami, Anna Barattucci, Luigi Monsu Scolaro, Maurizio Viale, Giuseppina Raffaini, Paola Maria Bonaccorsi, Antonino Mazzaglia
Summary: This article introduces the potential application of non-ionic cyclodextrin-based nanoassemblies as nanocomplex adjuvants in anticancer therapy. The nanoassemblies were prepared by solvent evaporation method and characterized by spectroscopic techniques. Theoretical studies were performed to understand the formation and stability of the nanoassemblies. Experimental results showed that the nanoassemblies exhibited similar anticancer activity to free curcumin in different cancer cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Zilin Song, Jiaojiao Yin, Peifu Xiao, Jin Chen, Jingxin Gou, Yanjiao Wang, Yu Zhang, Tian Yin, Xing Tang, Haibing He
Summary: This study investigated three preparations, including nanosuspensions, liposomes, and phospholipid complexes, to improve the oral bioavailability of Breviscapine. The results showed that BVP-PLC was the most optimal preparation, and the drug-lipid ratio of 1:2 was found to be the most satisfactory for balancing drug loading and release.
Article
Chemistry, Applied
Xing Qiao, Lu Yang, Xinxin Hu, Yunrui Cao, Zhaojie Li, Jie Xu, Changhu Xue
Summary: This study focused on characterizing and evaluating inclusion complexes between astaxanthin esters and hydroxypropyl-beta-cyclodextrin. The results showed that Asta-C22:6 had the best binding capacity among the complexes, with positive effects on anticancer activity, oral bioavailability, and storage stability. Overall, forming inclusion complexes with HP beta-CD is an effective method to enhance the solubility and stability of Asta-E for potential future applications.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Sangita Bhattacharyya, Hindole Ghosh, Obdulia Covarrubias-Zambrano, Krishan Jain, K. Venkateswara Swamy, Anup Kasi, Ameer Hamza, Shrikant Anant, Michael VanSaun, Scott J. Weir, Stefan H. Bossmann, Subhash B. Padhye, Prasad Dandawate
Summary: Pancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer-related deaths in the US. The development of novel drugs with improved delivery is crucial due to factors such as genetic mutations, drug resistance, multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma. Curcumin shows promise in inhibiting PDAC, but its clinical applicability is limited by poor solubility and metabolic instability. A difluorinated curcumin analog (CDF) has been developed, which selectively accumulates in the pancreas and inhibits PDAC growth. Its inclusion complex with 2-hydroxy-propyl-beta-cyclodextrin (HCD) increases water solubility and hydrolytic stability, leading to improved therapeutic efficacy against PDAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Longwei Jiang, Ning Xia, Fenghui Wang, Cancan Xie, Rong Ye, Hongjie Tang, Huajiang Zhang, Yingzhu Liu
Summary: This study successfully synthesized curcumin/beta-cyclodextrin inclusion complex nanoparticles using flexible and efficient nanoprecipitation method. The encapsulation efficiency reached over 70% at a ratio of 1:2 or 1:1, and the particle size was around 200 nm. The results from various characterization techniques confirmed the construction of nanoparticles and their stability. Encapsulation of curcumin improved its bioavailability, and the nanoparticles exhibited excellent physicochemical stability. Nanoprecipitation shows promise in synthesizing CD-based nanoparticles with enhanced stability and bioavailability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Emma Adriana Ozon, Marian Novac, Daniela Gheorghe, Adina Magdalena Musuc, Mirela Adriana Mitu, Iulian Sarbu, Valentina Anuta, Adriana Rusu, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The novelty of this study lies in the development of new orodispersible tablets containing nifedipine as the active ingredient. The study successfully prepared inclusion complexes of nifedipine with two derivatives of beta-cyclodextrin and analyzed their physicochemical properties. Orodispersible tablets containing the inclusion complexes were also successfully manufactured.
Article
Pharmacology & Pharmacy
Bhupendra Raj Giri, Hyun Seok Yang, Im-Sook Song, Han-Gon Choi, Jung Hyun Cho, Dong Wuk Kim
Summary: This study developed spray-dried amorphous inclusion complexes of methotrexate (MTX) with beta-cyclodextrin derivatives to enhance the drug's solubility, stability, and oral bioavailability in rats. The findings showed significant improvements in pharmacokinetic profiles with DM-beta-CD as the host, indicating a successful oral formulation technique for preventing drug degradation and enhancing pharmacological properties.
Article
Biochemistry & Molecular Biology
Marian Novac, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Mirela Adriana Mitu, Adriana Rusu, Daniela Gheorghe, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The aim of this study was to manufacture new orally disintegrating tablets containing nimodipine-hydroxypropyl-beta-cyclodextrin and nimodipine-methyl-beta-cyclodextrin inclusion complexes. Three methods of preparation were compared, and the lyophilization method was found to be more effective. The formulation and precompression studies for the tablets containing the inclusion complexes were successfully assessed.
Article
Biochemistry & Molecular Biology
Wen Zhu, Yue Lv, QiLei Yang, Yuangang Zu, Xiuhua Zhao
Summary: This study aimed to enhance the oral bioavailability of ART by including it with HP-8-CD and then loaded with PS. The prepared AHPS showed higher solubility and bioavailability compared to ART and APT, and exhibited better antimalarial activity. This research provides a new idea for the development and application of fat-soluble drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Yuru Huang, Xueyuan Hu, Hua Zhao, Dan He, Yi Li, Mei Yang, Zhongshu Yu, Kailing Li, Jingqing Zhang
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Zhenhua Li, Sathishkumar Chinnasamy, Yonghong Zhang, Dong-Qing Wei
Summary: Microcins are small bacterial inhibitory molecules produced by ribosomes, with Microcin J25 having a unique lasso-like structure. The binding of Microcin J25 to its target receptor FhuA is essential for its inhibitory function, with specific amino acid mutations affecting the binding energy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Nanoscience & Nanotechnology
Jing Gu, Yongjia Huang, Zijun Yan, Dan He, Yonghong Zhang, Jingyu Xu, Yao Li, Xuemei Xie, Jiaxi Xie, Da Shi, Ruben Abagyan, Jingqing Zhang, Qunyou Tan
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Xiaoqian He, Jiao Feng, Shenglei Yan, Yonghong Zhang, Cailing Zhong, Yuying Liu, Da Shi, Ruben Abagyan, Tingxiu Xiang, Jingqing Zhang
Summary: A novel biomimetic nanovesicle-loaded supramolecular enzyme-based therapeutic has been developed, utilizing various technologies to combine multiple functional motifs for effective transport of arginine deiminase (ADI) to hepatic tumor cells. The antitumor effects were enhanced by the unique combination of enzyme treatment and components like TPGS within the nanovesicle.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Environmental
Weina Dai, Tiantian Tang, Zhenghua Dai, Da Shi, Lingyun Mo, Yonghong Zhang
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2020)
Article
Chemistry, Applied
Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang
Summary: This study investigated the noncovalent mechanism of inhibiting the antigenicity of beta-LG by six flavonoids, with EGCG showing the highest antigenic inhibition rate. The flavonoids induced conformational changes in beta-LG and bound to specific antigen epitopes to decrease protein antigenicity.
Article
Biochemical Research Methods
Hong Wang, Jingqing Zhang, Zhigang Lu, Weina Dai, Chuanjiang Ma, Yun Xiang, Yonghong Zhang
Summary: This study developed useful drug repurposing tools based on data-driven modeling and network pharmacology. Hub proteins important in the onset and development of COVID-19 were identified as potential targets for repurposing approved drugs. The study also predicted the therapeutic effects of bioactive herbal ingredients and chemicals using network distance metrics in the protein-protein interaction network. The method proves to be advantageous in feasibility analysis of drug repurposing or drug screening during pandemic outbreaks.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Pharmacology & Pharmacy
Tingting Wang, Di Qi, Xueyuan Hu, Na Li, Xue Zhang, Hongming Liu, Cailing Zhong, Jingqing Zhang
Summary: The amino derivative EVA exhibits improved bioavailability and enhanced anti-tumor activity against small cell lung cancer. It interacts with serum albumin and regulates the PI3K/AKT signaling pathway to induce apoptosis in tumor cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Ran Chen, Tingting Wang, Jie Song, Daojun Pu, Dan He, Jianjun Li, Jie Yang, Kailing Li, Cailing Zhong, Jingqing Zhang
Summary: Antiviral drugs play a crucial role in fighting viruses, including COVID-19, but their use is often limited by poor oral bioavailability and low efficacy. Studying the metabolism and pharmacokinetic characteristics of AvDs can help improve their effectiveness and combat drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Yongjia Huang, Tingting Wang, Qunyou Tan, Dan He, Mingjun Wu, Jingchuan Fan, Jie Yang, Cailing Zhong, Kailing Li, Jingqing Zhang
Summary: The article discusses the challenges of delivering therapeutic agents specifically to dysfunctional mitochondria in tumor progression and presents a variety of pathways to achieve smart stimuli-responsive and mitochondria-targeted drug delivery systems. These systems not only target the mitochondria with precision but also respond to internal and external stimuli to increase efficacy and reduce side effects, showing promise as a potential precision medicine for cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Food Science & Technology
Wei Luo, Hui Huang, Yonghong Zhang, Faxiang Wang, Jian Yu, Yongle Liu, Xianghong Li
Summary: This study investigated the complex coacervation of rice glutelin and gum arabic under different conditions and found that the formation of maximum complex occurred at specific mass ratios, NaCl concentrations, and in the presence of urea, indicating different structures and interactions between the biopolymers. The molecular docking analysis revealed that hydrogen bonding and hydrophobic interaction, in addition to electrostatic interaction, were the main driving forces for the formation of the RG-GA complex coacervation, providing valuable theoretical and methodological information for the use of rice protein in food products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zheng Cheng, Yonghong Zhang, Yang Zhuo, Jie Fan, Ying Xu, Mengmeng Li, Hao Chen, Li Zhou
Summary: This study found that the rs2327433 site in lncRNA TARID was associated with the risk of coronary artery disease (CAD) and the severity of the disease in the Chinese Han population. Further analysis showed that the rs2327433 site may affect the expression of the atherosclerosis-related transcription factor TCF21 regulated by lncRNA TARID. The study revealed a new mechanism of lncRNA-mediated cell proliferation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemical Research Methods
Tiantian Tang, Xiaofeng Gan, Li Zhou, Kexue Pu, Hong Wang, Weina Dai, Bo Zhou, Lingyun Mo, Yonghong Zhang
Summary: A novel method based on network strategies and machine learning algorithms has been developed to explore the drug-induced liver injury (DILI). The method provides a new approach to predict the hepatotoxicity of drugs and understand the mechanism behind DILI.
CURRENT BIOINFORMATICS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)