Combined Delivery of Temozolomide and siPLK1 Using Targeted Nanoparticles to Enhance Temozolomide Sensitivity in Glioma

Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/β-catenin signaling pathway

(2018) Cong Zhang et al.   GENE

Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies

(2018) Nausicaa Clemente et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Codelivery of temozolomide and siRNA with polymeric nanocarrier for effective glioma treatment

(2018) Yuan Peng et al.   International Journal of Nanomedicine

Association between SOX9 and CA9 in glioma, and its effects on chemosensitivity to TMZ

(2018) Xiaoshan Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Essential Role of Polo-like Kinase 1 (Plk1) Oncogene in Tumor Growth and Metastasis of Tamoxifen-Resistant Breast Cancer

(2018) Sung Baek Jeong et al.   MOLECULAR CANCER THERAPEUTICS

A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models

(2018) Nicole Salazar et al.   MOLECULAR THERAPY

The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle

(2018) Dao-zhou Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

(2018) Fred C. Lam et al.   Nature Communications

Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy

(2018) Elif Ozdemir-Kaynak et al.   Frontiers in Physiology

Silencing SATB1 overcomes temozolomide resistance by downregulating MGMT expression and upregulating SLC22A18 expression in human glioblastoma cells

(2018) Biao Yang et al.   CANCER GENE THERAPY

Polo-like kinase 1 inhibitor BI 6727 induces DNA damage and exerts strong antitumor activity in small cell lung cancer

(2018) Yuehong Wang et al.   CANCER LETTERS

PLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells

(2018) Naijie Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

MicroRNA miR-509 Regulates ERK1/2, the Vimentin Network, and Focal Adhesions by Targeting Plk1

(2018) Guoning Liao et al.   Scientific Reports

Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells

(2018) Gábor Petővári et al.   Cancer Cell International

ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1

(2018) Tongle Zhi et al.   NEURO-ONCOLOGY

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor

(2018) Yipu Fan et al.   Cancers

Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy

(2017) Hong-Mei Liu et al.   International Journal of Nanomedicine

VPA and MEL induce apoptosis by inhibiting the Nrf2-ARE signaling pathway in TMZ-resistant U251 cells

(2017) Hao Pan et al.   Molecular Medicine Reports

Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide

(2017) Sang-Soo Kim et al.   NUCLEIC ACIDS RESEARCH

Temozolomide encapsulated and folic acid decorated chitosan nanoparticles for lung tumor targeting: improving therapeutic efficacy both in vitro and in vivo

(2017) Kaidi Li et al.   Oncotarget

PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas

(2017) Robert F. Koncar et al.   Oncotarget

Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics

(2016) Rosie Elizabeth Ann Gutteridge et al.   MOLECULAR CANCER THERAPEUTICS

Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations

(2016) Yuehong Wang et al.   Oncotarget

Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

(2016) Mariia Patyka et al.   Oncotarget

Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells

(2016) Ping Liang et al.   Oncotarget

Temozolomide Nanoparticles for Targeted Glioblastoma Therapy

(2015) Chen Fang et al.   ACS Applied Materials & Interfaces

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

(2015) R. G. Lerner et al.   CANCER RESEARCH

Vincristine and temozolomide combined chemotherapy for the treatment of glioma: a comparison of solid lipid nanoparticles and nanostructured lipid carriers for dual drugs delivery

(2015) Miaojing Wu et al.   DRUG DELIVERY

Combined Delivery of Temozolomide and Anti-miR221 PNA Using Mesoporous Silica Nanoparticles Induces Apoptosis in Resistant Glioma Cells

(2015) Alessandro Bertucci et al.   Small

Polo-like kinase 1 inhibition sensitizes neuroblastoma cells for vinca alkaloid-induced apoptosis

(2015) Sebastian Czaplinski et al.   Oncotarget

Direct Cytosolic Delivery of siRNA Using Nanoparticle-Stabilized Nanocapsules

(2014) Ying Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy

(2014) Yan Li et al.   BIOMATERIALS

SiRNA-phospholipid conjugates for gene and drug delivery in cancer treatment

(2014) Hongmei Liu et al.   BIOMATERIALS

Polymersomes conjugated with des-octanoyl ghrelin and folate as a BBB-penetrating cancer cell-targeting delivery system

(2014) Yung-Chu Chen et al.   BIOMATERIALS

Anti-epidermal growth factor receptor siRNA carried by chitosan-transacylated lipid nanocapsules increases sensitivity of glioblastoma cells to temozolomide

(2014) Frederic Lagarce et al.   International Journal of Nanomedicine

Combination Treatment with Theranostic Nanoparticles for Glioblastoma Sensitization to TMZ

(2014) Byunghee Yoo et al.   MOLECULAR IMAGING AND BIOLOGY

Improvement of Doxorubicin Efficacy Using Liposomal Anti-Polo-like Kinase 1 siRNA in Human Renal Cell Carcinomas

(2014) Yu Sakurai et al.   MOLECULAR PHARMACEUTICS

Monodispersed Brush-Like Conjugated Polyelectrolyte Nanoparticles with Efficient and Visualized SiRNA Delivery for Gene Silencing

(2013) Rongcui Jiang et al.   BIOMACROMOLECULES

Cationic core–shell nanoparticles with carmustine contained within O6-benzylguanine shell for glioma therapy

(2013) Lili Qian et al.   BIOMATERIALS

Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance

(2012) Mar Creixell et al.   Nano Today

Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat

(2011) Du Cheng et al.   BIOMATERIALS

The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy

(2010) Mathilde Roger et al.   BIOMATERIALS

Polo-like Kinase 1 (Plk1) as a Novel Drug Target in Chronic Myeloid Leukemia: Overriding Imatinib Resistance with the Plk1 Inhibitor BI 2536

(2010) K. V. Gleixner et al.   CANCER RESEARCH

pH-Responsive Polymeric siRNA Carriers Sensitize Multidrug Resistant Ovarian Cancer Cells to Doxorubicin via Knockdown of Polo-like Kinase 1

(2010) Danielle S. W. Benoit et al.   MOLECULAR PHARMACEUTICS