S-Adenosine Methionine (SAMe) and Valproic Acid (VPA) as Epigenetic Modulators: Special Emphasis on their Interactions Affecting Nervous Tissue during Pregnancy

Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA)

(2020) Liza Weinstein-Fudim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the inhibitory activity of valproic acid against the HDAC family using an MMGBSA approach

(2020) Yudibeth Sixto-López et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

S-Adenosyl Methionine (SAMe) for Depression in Adults

(2019) Amanda Wilson   Issues in Mental Health Nursing

Histone Modifications as an Intersection Between Diet and Longevity

(2019) Diego Molina-Serrano et al.   Frontiers in Genetics

Genome-wide DNA methylation analysis of pituitaries during the initiation of puberty in gilts

(2019) Xiaolong Yuan et al.   PLoS One

Developing differences: early-life effects and evolutionary medicine

(2019) Bram Kuijper et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

(2019) Soham Chanda et al.   Cell Stem Cell

Valproic acid effect on neural tube defects is not prevented by concomitant folic acid supplementation: Early chick embryo model pilot study”

(2019) U. Turgut et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Down-regulation of TrkB expression and signalling by valproic acid and other histone deacetylase inhibitors

(2019) Simona Dedoni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer’s disease

(2019) Emily R. Mahoney et al.   MOLECULAR PSYCHIATRY

Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?

(2019) Liza Weinstein-Fudim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The longitudinal relationship between changes in wellbeing and inflammatory markers: Are associations independent of depression?

(2019) Daisy Fancourt et al.   BRAIN BEHAVIOR AND IMMUNITY

A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring

(2018) Chelsea R. McCoy et al.   BIOSCIENCE REPORTS

Repurposing medications for use in treating HIV infection: A focus on valproic acid as a latency-reversing agent

(2018) B. Crosby et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice

(2018) Asher Ornoy et al.   NEUROTOXICOLOGY AND TERATOLOGY

Postnatal DNA demethylation and its role in tissue maturation

(2018) Yitzhak Reizel et al.   Nature Communications

N-acetylcysteine as add-on to antidepressant medication in therapy refractory major depressive disorder patients with increased inflammatory activity: study protocol of a double-blind randomized placebo-controlled trial

(2018) Chenghao Yang et al.   BMC Psychiatry

Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial,

(2018) Jerome Sarris et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

(2017) Renata H. Bahous et al.   HUMAN MOLECULAR GENETICS

Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides

(2017) Anke Hoffmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

S-Adenosylmethionine Attenuates Oxidative Stress and Neuroinflammation Induced by Amyloid-β Through Modulation of Glutathione Metabolism

(2017) Qian Li et al.   JOURNAL OF ALZHEIMERS DISEASE

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

(2017) Matthias S. Roost et al.   Nature Communications

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

(2017) Maria Saveria Gilardini Montani et al.   CELLULAR ONCOLOGY

Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

(2017) Kyoko Hasebe et al.   ACTA NEUROPSYCHIATRICA

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function

(2017) et al.   Genes

S-Adenosylmethionine Prevents Oxidative Stress and Modulates Glutathione Metabolism in TgCRND8 Mice Fed a B-Vitamin Deficient Diet

(2017) Rosaria A. Cavallaro et al.   JOURNAL OF ALZHEIMERS DISEASE

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

(2016) Domenico De Berardis et al.   CNS & Neurological Disorders-Drug Targets

Allosteric control of mammalian DNA methyltransferases – a new regulatory paradigm

(2016) Albert Jeltsch et al.   NUCLEIC ACIDS RESEARCH

Upregulation of CD54 and downregulation of HLA-ABC contribute to the novel enhancement of the susceptibility of HL-60 cells to NK cell-mediated cytolysis induced by ATRA plus VPA

(2016) Huijuan Zou et al.   ONCOLOGY REPORTS

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

(2016) Emily A. Saunderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study

(2016) Paulo L. Lizano et al.   SCHIZOPHRENIA RESEARCH

Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders

(2016) M M Darby et al.   Translational Psychiatry

Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood

(2016) Kristian Almstrup et al.   Scientific Reports

Developmental origins of health and disease – Global public health implications

(2015) M.A. Hanson et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Association of serum VEGF levels with prefrontal cortex volume in schizophrenia

(2015) A Pillai et al.   MOLECULAR PSYCHIATRY

Prospects for the development of epigenetic drugs for CNS conditions

(2015) Moshe Szyf   NATURE REVIEWS DRUG DISCOVERY

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

(2015) Magdaléna Vaváková et al.   Oxidative Medicine and Cellular Longevity

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

Prenatal factors associated with autism spectrum disorder (ASD)

(2015) A. Ornoy et al.   REPRODUCTIVE TOXICOLOGY

S-Adenosyl-L-Methionine for the Treatment of Chronic Liver Disease: A Systematic Review and Meta-Analysis

(2015) Tao Guo et al.   PLoS One

A Meta-Analysis of Oxidative Stress Markers in Depression

(2015) Tao Liu et al.   PLoS One

Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

(2015) Hiroo Nakashima et al.   PLoS One

Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice

(2014) B. Pragnya et al.   BEHAVIOURAL BRAIN RESEARCH

Reprogramming the Methylome: Erasing Memory and Creating Diversity

(2014) Heather J. Lee et al.   Cell Stem Cell

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

(2014) Meelad M. Dawlaty et al.   DEVELOPMENTAL CELL

Valproate and folic acid in pregnancy: associations with autism

(2014) Peter Baxter   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The Efficacy of AdjunctiveN-Acetylcysteine in Major Depressive Disorder

(2014) Michael Berk et al.   JOURNAL OF CLINICAL PSYCHIATRY

Oral SAMe in Persistent Treatment-Refractory Bipolar Depression

(2014) Beth L. Murphy et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Age-dependent effects of valproic acid in Alzheimer’s disease (AD) mice are associated with nerve growth factor (NGF) regulation

(2014) H. Noh et al.   NEUROSCIENCE

MeCP2: the long trip from a chromatin protein to neurological disorders

(2014) Juan Ausió et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

(2013) Randal X. Moldrich et al.   BEHAVIOURAL BRAIN RESEARCH

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

(2013) Joanna Rybka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Histone modifications for human epigenome analysis

(2013) Hiroshi Kimura   JOURNAL OF HUMAN GENETICS

Mitochondrial abnormalities in temporal lobe of autistic brain

(2013) Guomei Tang et al.   NEUROBIOLOGY OF DISEASE

Valproic acid pathway

(2013) Yogita Ghodke-Puranik et al.   Pharmacogenetics and Genomics

Oxidative Stress and Erythrocyte Membrane Alterations in Children with Autism: Correlation with Clinical Features

(2013) Alessandro Ghezzo et al.   PLoS One

Lipid Peroxidation and Depressed Mood in Community-Dwelling Older Men and Women

(2013) Yuri Milaneschi et al.   PLoS One

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression

(2012) Shang-Feng Gao et al.   CEREBRAL CORTEX

Tet family proteins and 5-hydroxymethylcytosine in development and disease

(2012) L. Tan et al.   DEVELOPMENT

Why are antiepileptic drugs used for nonepileptic conditions?

(2012) Meir Bialer   EPILEPSIA

S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice

(2012) Andrea Fuso et al.   NEUROBIOLOGY OF AGING

Antioxidants as potential therapeutics for neuropsychiatric disorders

(2012) Chirayu D. Pandya et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes

(2012) Corina Nagy et al.   Epigenomics

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals

(2011) David Banji et al.   BRAIN RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

DNA methylation profiles of human active and inactive X chromosomes

(2011) A. J. Sharp et al.   GENOME RESEARCH

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

(2011) Shunsuke Kataoka et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

DNA Methylation and Demethylation in Mammals

(2011) Zhao-xia Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

(2011) L. Gobejishvili et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

(2011) Zhen Huang et al.   NEUROSCIENCE LETTERS

S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

(2010) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

Hepatoprotective effects ofS-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

(2010) Arthur I Cederbaum   WORLD JOURNAL OF GASTROENTEROLOGY

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure–function studies for the panacea, valproic acid

(2009) Nicole Terbach et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Serum VEGF levels in acute ischaemic strokes are correlated with long-term prognosis

(2009) S.-C. Lee et al.   EUROPEAN JOURNAL OF NEUROLOGY

Homocysteine, folate and vitamin B12in neuropsychiatric diseases: review and treatment recommendations

(2009) Olaf Stanger et al.   Expert Review of Neurotherapeutics

Enhanced Adult Neurogenesis and Angiogenesis and Altered Affective Behaviors in Mice Overexpressing Vascular Endothelial Growth Factor 120

(2009) H. Udo et al.   JOURNAL OF NEUROSCIENCE

Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

(2009) Birgul Elbozan Cumurcu et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Valproic acid in pregnancy: How much are we endangering the embryo and fetus?

(2009) Asher Ornoy   REPRODUCTIVE TOXICOLOGY

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

(2008) Ainhoa Iglesias Ara et al.   HEPATOLOGY

In utero supplementation with methyl donors enhances allergic airway disease in mice

(2008) John W. Hollingsworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reading and writing DNA methylation

(2008) Albert Jeltsch   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antidepressant activity of curcumin: involvement of serotonin and dopamine system

(2008) Shrinivas K. Kulkarni et al.   PSYCHOPHARMACOLOGY

Mammalian DNA Methyltransferases: A Structural Perspective

(2008) Xiaodong Cheng et al.   STRUCTURE