Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling

Quantification of dynamic protein interactions and phosphorylation in LPS signaling pathway by SWATH-MS

(2019) Xiurong Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

(2019) Caleb J. Bashor et al.   SCIENCE

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules

(2016) Hao Wu et al.   CELL

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

(2016) Daniel R. Ram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

A Cross-Disciplinary Perspective on the Innate Immune Responses to Bacterial Lipopolysaccharide

(2014) Yunhao Tan et al.   MOLECULAR CELL

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF- B Activation

(2014) H. Shinohara et al.   SCIENCE

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

(2010) Takashi Nakakuki et al.   CELL

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling

(2009) Leah E. Cole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE