Review
Chemistry, Medicinal
Yuanzhen Xu, Hongbo Wei, Jinming Gao
Summary: Neuroinflammation, characterized by the activation of microglia, plays a critical role in the pathogenesis of many neurodegenerative diseases. Research on neuroinflammatory inhibitors, such as terpenoids, is essential for developing treatments for these diseases. Bacterial lipopolysaccharide is widely used in studies of brain inflammation and contributes to the understanding of neuroinflammatory mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Benita Wiatrak, Paulina Jawien, Agnieszka Matuszewska, Adam Szelag, Adriana Kubis-Kubiak
Summary: This study aimed to investigate the impact of amyloid fragments on oxidative stress and found that amyloid fragments have antioxidant properties, protecting neurons from neuroinflammation-induced damage. Among the tested fragments, the 1-40 fragment showed a stronger antioxidant effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Yusheng Liang, Xu Kang, Haiwang Zhang, Heng Xu, Xian Wu
Summary: Inhibition of GPR17 improves cognitive impairment induced by LPS in mice. In addition to improving cholinergic dysfunction, inhibition of GPR17 also regulates oxidative stress and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Jin-Hee Park, Jeong-Woo Hwang, Hyun-ju Lee, Geum Mi Jang, Yoo Joo Jeong, Joonho Cho, Jinsoo Seo, Hyang-Sook Hoe
Summary: This study found that lomerizine has inhibitory effects on neuroinflammatory response and tau protein phosphorylation, making it a potential drug for neuroinflammation- or tauopathy-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Shunling Yuan, Jialun Yang, Ye Jian, Yong Lei, Sisi Yao, Zelin Hu, Xia Liu, Changfa Tang, Wenfeng Liu
Summary: This study investigated the effects of treadmill exercise on neuroinflammation in APP/PS1 transgenic AD mice and found that exercise can enrich gut microbial diversity and alleviate neuroinflammation in the brain. Exercise led to reductions in pathogenic bacteria, increases in probiotic bacteria, increased levels of intestine-brain barrier proteins, and attenuated LPS displacement.
Article
Cell Biology
Veronica Mutti, Giulia Carini, Alice Filippini, Stefania Castrezzati, Lorena Giugno, Massimo Gennarelli, Isabella Russo
Summary: Chronic neuroinflammation is a crucial factor in the progression of neurodegenerative diseases like Parkinson's and Alzheimer's. The gene LRRK2, which is mutated in these diseases, has been identified as a key mediator of neuroinflammation. This study further validated LRRK2 kinase inhibition as a potential therapeutic intervention for neuroinflammation in preclinical models of Alzheimer's and Parkinson's.
Article
Biochemistry & Molecular Biology
Shun Huang, Wenfeng Liu, Yonglian Li, Kun Zhang, Xi Zheng, Hubing Wu, Ganghua Tang
Summary: Neuroinflammatory cytokines are promising therapeutic targets for Alzheimer's disease, and cinnamic acid derivatives, particularly compound 4f, have shown potential as effective antineuroinflammatory agents. Through structural modifications, compound 4f was found to directly bind to the MAPK signaling pathway, blocking neuroinflammatory progression. Docking studies further revealed the compound's interaction with IL-1 beta and enhanced binding affinity, which are significant for Alzheimer's disease treatment development.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Barbara E. Stopschinski, Rick A. Weideman, Danni McMahan, David A. Jacob, Bertis B. Little, Hsueh-Sheng Chiang, Nil Saez Calveras, Olaf Stuve
Summary: Alzheimer's disease (AD) is an untreatable cause of dementia, and there is an urgent need for new therapeutic approaches. Research suggests that neuroinflammation plays a critical role in the pathophysiology of AD, leading to the idea that anti-inflammatory treatments might be beneficial. Recent studies have shown the protective effects of diclofenac and NSAIDs in the fenamate group for targeting AD pathology.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neurosciences
Yueting Guo, Shiyi Wang, Li Li, Hengce Zhang, Xiaoyang Chen, Zihan Huang, Yingchun Liu
Summary: The study aimed to evaluate the anti-inflammatory role of LMP2 deficiency in Alzheimer's disease (AD). The results showed that LMP2 was upregulated in the brains of AD mice and increased with age in normal mice. Further experiments revealed that the lack of LMP2 significantly decreased NLRP3 expression and cytokine release, ameliorating cognitive deficits in AD model mice and aged mice.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dai-Di Li, Hong-Xia Fan, Rong Yang, Ying-Ying Li, Feng Zhang, Jing-Shan Shi
Summary: DNLA can provide neuroprotection by protecting hippocampal neurons and working memory against LPS-induced neurotoxicity. The neuroprotective effect of DNLA is mediated by the inhibition of NLRP3 inflammasome activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Prasenjit Mondal, Ping Bai, Ashley Gomm, Grisilda Bakiasi, Chih-Chung Jerry Lin, Yanli Wang, Se Hoon Choi, Rudolph E. Tanzi, Changning Wang, Can Zhang
Summary: This study aims to investigate the pathological accumulation of HDAC6 in Alzheimer's disease and its relationship with amyloid pathogenesis and pathophysiological alterations. The results indicate that HDAC6 plays key roles in the pathophysiology of AD, making it a potential pharmacological target for AD drug discovery.
Article
Biochemistry & Molecular Biology
Soraya Wilke Saliba, Franziska Glaeser, Anke Deckers, Albrecht Keil, Thomas Hurrle, Matthias Apweiler, Florian Ferver, Nicole Volz, Dominique Endres, Stefan Braese, Bernd L. Fiebich
Summary: Neuroinflammation is important for CNS homeostasis, but chronic neuroinflammation can lead to disorders like AD and depression. Research on the novel GPR55 receptor antagonist KIT 10 in microglia revealed its ability to reduce neuroinflammatory parameters by inhibiting the COX-2/PGE(2) pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Lingyun Yue, Pu Liu, Ningtian Ma, Yuxia Xu, Cuiqing Zhu
Summary: Neuroinflammation is a major factor in Alzheimer's disease, with the presence of LPS in senile plaques indicating its role in AD pathology. The protein ATP5A1 has been found to interact with LPS and alleviate LPS-induced symptoms in a mouse model of neuroinflammation, showing potential in regulating LPS-mediated neuroinflammation in AD.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Dongming Guo, Yang Xu, Zhenghai Liu, Yingge Wang, Xiaofan Xu, Cai Li, Suyun Li, Jingwen Zhang, Tianqing Xiong, WenYu Cao, Jingyan Liang
Summary: The role of IGF2 in modulating microglia response to neuroinflammation and its potential therapeutic effects on neuropsychiatric disorders are investigated in this study. The results showed that systemic administration of IGF2 could inhibit microglia over-activation and prevent their transformation to a pro-inflammatory phenotype, thus protecting hippocampal neurogenesis. These findings may contribute to the development of innovative therapy for neuropsychiatric disorders.
BRAIN RESEARCH BULLETIN
(2023)
Article
Chemistry, Medicinal
Mattia Di Paolo, Francesca Corsi, Chiara Cerri, Silvia Bisti, Ilaria Piano, Claudia Gargini
Summary: Neuroinflammation is a mechanism shared by most neurodegenerative diseases, and the retina plays a crucial role in linking cognitive impairment and visual function under neuroinflammatory conditions. The study shows that saffron Repron (R) can reduce neuroinflammation and prevent cognitive and visual impairment.
Article
Biochemistry & Molecular Biology
Piotr Swiatek, Teresa Glomb, Agnieszka Dobosz, Tomasz Gebarowski, Kamil Wojtkowiak, Aneta Jezierska, Jaroslaw J. Panek, Malgorzata Swiatek, Malgorzata Strzelecka
Summary: Chronic inflammation plays a significant role in major human diseases, with prostaglandin E-2 and COX activator being implicated in tumor growth. Existing anti-inflammatory drugs have limitations, thus the development of new compounds with potential anticancer activity and safety is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Patrycja Grosman-Dziewiszek, Benita Wiatrak, Wojciech Dziewiszek, Paulina Jawien, Remigiusz Mydlikowski, Romuald Bolejko, Marta Szandruk-Bender, Ewa Karuga-Kuzniewska, Adam Szelag
Summary: This study explored the effects of 40 Hz and 100 Hz vibrations on cell differentiation and proliferation, finding that vibrations enhance cell differentiation and the growth of neuronal cells.
Article
Cell Biology
Maciej Danielewski, Sylwia Zielinska, Agnieszka Matuszewska, Wojciech Slupski, Maciej Wlodarczyk, Izabela Jeskowiak, Benita Wiatrak, Krzysztof Kowalski, Anna Jezierska-Domaradzka, Piotr Ziolkowski, Adam Szelag, Beata Nowak
Summary: This study evaluated the anti-inflammatory activity of the sanguinarine-chelerythrine fraction of Coptis chinensis and found that it has a lower gastrotoxic activity compared to existing nonsteroidal anti-inflammatory drugs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Immunology
Helena Moreira, Agnieszka Dobosz, Lucja Cwynar-Zajac, Paulina Nowak, Marek Czyzewski, Marta Barg, Pawel Reichert, Aleksandra Krolikowska, Ewa Barg
Summary: This review summarizes the role of regulatory B cells (Breg cells) in pathological conditions of the gastrointestinal tract. The origin, phenotype, suppressive mechanisms, and the relationship between Breg cells and gut microbiota are discussed. The focus is on the role of Breg cells in diseases such as Helicobacter pylori infection, parasitic diseases, and gastrointestinal neoplasms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maciej Danielewski, Agnieszka Gomulkiewicz, Alicja Z. Kucharska, Agnieszka Matuszewska, Beata Nowak, Narcyz Piorecki, Malgorzata Trocha, Marta Szandruk-Bender, Paulina Jawien, Adam Szelag, Piotr Dziegiel, Tomasz Sozanski
Summary: This study aimed to determine the effect of Cornelian cherry extract on the markers important in the progress of inflammation and atherosclerotic lesion development. It found that the extract at a dose of 50 mg/kg bw resulted in a significant reduction in inflammation markers and serum levels related to atherosclerosis. The results suggest the potential usefulness of Cornelian cherry extract in preventing or treating atherosclerosis-related cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Matuszewska, Krzysztof Kowalski, Paulina Jawien, Tomasz Tomkalski, Dagmara Gawel-Dabrowska, Anna Merwid-Lad, Ewa Szelag, Karolina Blaszczak, Benita Wiatrak, Maciej Danielewski, Janusz Piasny, Adam Szelag
Summary: Schizophrenia is a severe mental disorder caused by gene-environment interactions. Sex hormones, particularly testosterone, may play a role in the development and clinical features of male schizophrenic patients. Altered testosterone levels have been observed in men with schizophrenia, but the relationship between testosterone and clinical symptoms is complex and contradictory. Factors such as the phase of the disease, specific symptoms, and antipsychotic treatment may influence testosterone levels. Various factors, including illness, stress, medication, obesity, substance abuse, and liver damage, can contribute to disruptions in testosterone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Szandruk-Bender, Beata Nowak, Anna Merwid-Lad, Alicja Z. Kucharska, Malgorzata Krzystek-Korpacka, Iwona Bednarz-Misa, Benita Wiatrak, Adam Szelag, Narcyz Piorecki, Tomasz Sozanski
Summary: Research suggests that cornelian cherry extract, rich in iridoids and polyphenols, has potential anti-inflammatory properties and can target specific molecules involved in the development of Th17/Treg cells. In an experimental colitis model, a dose of 100 mg/kg of cornelian cherry extract was effective in reducing inflammation and modulating immune factors related to Th17/Treg axis regulation. When administered with sulfasalazine, cornelian cherry extract showed even greater efficacy in reversing the pathological changes induced by colitis.
Review
Neurosciences
Benita Wiatrak, Paulina Jawien, Adam Szelag, Izabela Jeskowiak-Kossakowska
Summary: Alzheimer's disease is a neurodegenerative disease that leads to dementia, with no effective medicine currently available. The disease is characterized by the accumulation of proteins and inflammation in the brain, resulting in neuronal death. Neuroinflammation, often ignored in AD research, has gained attention recently, although the impact of comorbidities or gender differences remains unclear. This publication critically analyzes the role of inflammation in the progression of AD based on in vitro studies and other researchers' findings.
NEUROMOLECULAR MEDICINE
(2023)
Article
Food Science & Technology
Magdalena Grajzer, Benita Wiatrak, Paulina Jawien, Lukasz Marczak, Anna Wojakowska, Rafal Wiejak, Edward Roj, Wojciech Grzebieluch, Anna Prescha
Summary: Wild strawberry seed oil (WSO) recovered by cold pressing and extraction with supercritical carbon dioxide (SCO2E) was characterized for its composition and quality. The cytotoxicity of WSOs was assessed using a normal human dermal fibroblast (NHDF) cell line. Results showed that SCO2E-recovered WSO had higher tocopherol and total polyphenol contents compared to cold pressed oil. Carotenoids and squalene were highest in cold pressed oil. Phytosterol content reached 5396 mg/kg in WSO collected during 30 min of SCO2E. The highest oxidative stability was also found in this oil. All WSOs were non-cytotoxic in LDH leaching and SRB assays, but cytotoxic in the MTT test at certain concentrations for SCO2E oil collected in 15 and 30 min. The composition of WSO indicates different bio-potencies and applications depending on the extraction method.
Article
Chemistry, Multidisciplinary
Paulina Sobierajska, Benita Wiatrak, Paulina Jawien, Maciej Janeczek, Katarzyna Wiglusz, Adam Szelag, Rafal J. Wiglusz
Summary: This study investigates the impact of structure (XRPD, FT-IR) and surface morphology (SEM-EDS) of imatinib-functionalized galactose hydrogels, loaded and unloaded with nHAp, on osteosarcoma cell viability, levels of free oxygen radicals, and nitric oxide, levels of BCL-2, p53, and caspase 3 and 9, as well as glycoprotein-P activity. The study also examines how the rough surface of crystalline hydroxyapatite-modified hydrogels affects the release of amorphous imatinib (IM). The administration of IM and hydrogel composites shows potential in reducing the development of multidrug resistance by inhibiting P-gp.
Article
Biochemistry & Molecular Biology
Lukasz Szczukowski, Jadwiga Maniewska, Benita Wiatrak, Paulina Jawien, Edward Krzyzak, Aleksandra Kotynia, Aleksandra Marciniak, Maciej Janeczek, Aleksandra Redzicka
Summary: This study presents extensive evaluation of the biological, spectroscopic, and in silico properties of pyrrolo[3,4-c]pyrrole derivatives, which show promising anti-inflammatory and antioxidant activities with potentially good membrane permeability.
Article
Biochemistry & Molecular Biology
Jakub Mikus, Piotr Swiatek, Patrycja Przybyla, Edward Krzyzak, Aleksandra Marciniak, Aleksadra Kotynia, Aleksandra Redzicka, Benita Wiatrak, Paulina Jawien, Tomasz Gebarowski, Lukasz Szczukowski
Summary: In this study, a new series of NAH derivatives were synthesized and evaluated for their biological and physicochemical properties. The results showed that these compounds have potential COX/LOX inhibitory activity, and also form stable complexes with plasma proteins, suggesting good membrane permeability and bioavailability.
Article
Biochemistry & Molecular Biology
Tomasz Gebarowski, Benita Wiatrak, Izabela Jeskowiak-Kossakowska, Magdalena Grajzer, Anna Prescha
Summary: This study evaluated the potential of genetically modified flaxseed oils in preventing colorectal cancer. The results showed that flaxseed oil B exhibited the strongest anti-proliferative properties, and M and B oils enhanced accumulation of Rhodamine 123 and increased colorectal cancer cell apoptosis. M oil had the highest levels of p53 protein. These transgenic oils showed utility as adjuvants in colorectal cancer treatment, specifically targeting the colon.