Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages

Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells

(2019) Theo Stoddard-Bennett et al.   Cells

iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

(2019) Stephen Attwood et al.   Journal of Clinical Medicine

Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes

(2019) Mika Suga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pulmonary Transplantation of Human iPSC-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis

(2018) Christine Happle et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer

(2018) Mirco Ponzoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

‘Reprogrammed’ stem cells approved to mend human hearts for the first time

(2018) David Cyranoski   NATURE

Transplantation of human induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen consumption in a porcine model of myocardial infarction

(2018) Masaru Ishida et al.   TRANSPLANTATION

Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine

(2018) Takunori Nagashima et al.   Scientific Reports

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

(2018) Qin Liang et al.   NATURE

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

(2018) Mania Ackermann et al.   Nature Communications

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

(2017) Go Itakura et al.   Stem Cell Reports

TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis

(2017) Alexandra Kuhn et al.   Scientific Reports

Alveolar-like Stem Cell–derivedMyb−Macrophages Promote Recovery and Survival in Airway Disease

(2016) Michael L. Litvack et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Improving the safety of T-Cell therapies using an inducible caspase-9 gene

(2016) Xiaoou Zhou et al.   EXPERIMENTAL HEMATOLOGY

Tissue-resident macrophages - how to humanize our knowledge

(2016) Andreas Schlitzer et al.   IMMUNOLOGY AND CELL BIOLOGY

Macrophage-based cell therapies: The long and winding road

(2016) Simon Lee et al.   JOURNAL OF CONTROLLED RELEASE

Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

(2016) Shigeki Yagyu et al.   Molecular Therapy-Methods & Clinical Development

TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells

(2015) Anne-Kathrin Dreyer et al.   BIOMATERIALS

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

(2015) X. Zhou et al.   BLOOD

Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation

(2015) Hisayoshi Hashimoto et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

(2015) Shigeki Yagyu et al.   MOLECULAR THERAPY

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

(2015) Miki Ando et al.   Stem Cell Reports

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

(2015) Nico Lachmann et al.   Stem Cell Reports

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

(2014) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

(2014) C. Happle et al.   Science Translational Medicine

Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies

(2014) Chuanfeng Wu et al.   Molecular Therapy-Methods & Clinical Development

Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis

(2013) Nico Lachmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapeutic Effect of Human iPS-Cell–Derived Myeloid Cells Expressing IFN-β against Peritoneally Disseminated Cancer in Xenograft Models

(2013) Chihiro Koba et al.   PLoS One

Targeting colorectal cancer stem cells with inducible caspase-9

(2012) Kristel Kemper et al.   APOPTOSIS

Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells

(2012) Fei Chen et al.   BIOMATERIALS

Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery

(2012) Jiho Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY