Tumor Endothelial Cell—A Biological Tool for Translational Cancer Research

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

(2020) Jermaine Goveia et al.   CANCER CELL

Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial

(2019) Martin Reck et al.   Lancet Respiratory Medicine

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Brian I. Rini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial

(2019) Brian I Rini et al.   LANCET

Limitations of Anti-Angiogenic Treatment of Tumors

(2019) Domenico Ribatti et al.   Translational Oncology

Hallmarks of Endothelial Cell Metabolism in Health and Disease

(2019) Xuri Li et al.   Cell Metabolism

Trends and Challenges in Tumor Anti-Angiogenic Therapies

(2019) József Jászai et al.   Cells

Vasculogenic Mimicry: Become an Endothelial Cell “But Not So Much”

(2019) Mónica Fernández-Cortés et al.   Frontiers in Oncology

Targeting Tumor Endothelial Cells with Nanoparticles

(2019) Sakurai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor Endothelial Heterogeneity in Cancer Progression

(2019) Nako Maishi et al.   Cancers

Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

(2019) Dorcas A. Annan et al.   Cell Communication and Signaling

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

(2018) Anke Schlüter et al.   BMC CANCER

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

(2018) Ulrike Bruning et al.   Cell Metabolism

Monitoring of tumor vascular normalization: the key points from basic research to clinical application

(2018) Wei Li et al.   Cancer Management and Research

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance

(2017) Romana-Rea Begicevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-145 promoted anoikis resistance in tumor endothelial cells

(2017) Kyoko Hida et al.   JOURNAL OF BIOCHEMISTRY

Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial

(2017) Toni K. Choueiri et al.   JOURNAL OF CLINICAL ONCOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

COX‑2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression

(2017) Longhui Zhang et al.   Molecular Medicine Reports

The molecular cues regulating immune cell trafficking

(2017) Akira TAKEDA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics

(2017) Priti S. Hegde et al.   SEMINARS IN CANCER BIOLOGY

Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma

(2017) Kwang Hyun Kim et al.   Oncotarget

Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells

(2017) Peter Ping Lin et al.   Scientific Reports

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Role of the tumor stroma in resistance to anti-angiogenic therapy

(2016) Elisabeth J.M. Huijbers et al.   DRUG RESISTANCE UPDATES

Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

(2016) Victoria L Bridgeman et al.   JOURNAL OF PATHOLOGY

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

(2016) Elizabeth A. Kuczynski et al.   JNCI-Journal of the National Cancer Institute

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

(2016) Sophia Frentzas et al.   NATURE MEDICINE

Endothelial progenitor cells promote tumor growth and progression by enhancing new vessel formation

(2016) Xin Zhao et al.   Oncology Letters

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

(2016) Jeffrey J. Wallin et al.   Nature Communications

Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma

(2016) Elizabeth A. Kuczynski et al.   JNCI-Journal of the National Cancer Institute

Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies

(2016) Antonia Reale et al.   Stem Cells International

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

(2016) W. Liang et al.   Cancer Immunology Research

Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan

(2016) Nako Maishi et al.   Scientific Reports

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

The Evolving Role of Immune Checkpoint Inhibitors in Cancer Treatment

(2015) G. K. Pennock et al.   ONCOLOGIST

Endothelial Progenitor Cells in Tumor Angiogenesis: Another Brick in the Wall

(2015) Marina Marçola et al.   Stem Cells International

Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis

(2015) Arti Yadav et al.   PLoS One

Neoplastic cells are a rare component in human glioblastoma microvasculature

(2015) Fausto J. Rodriguez et al.   Oncotarget

Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy

(2014) Rajesh N. Gacche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumor Endothelial Markers Define Novel Subsets of Cancer-Specific Circulating Endothelial Cells Associated with Antitumor Efficacy

(2014) R. Mehran et al.   CANCER RESEARCH

Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype

(2014) Hitomi Ohmura-Kakutani et al.   PLoS One

Serum Endocan as a Novel Prognostic Biomarker in Patients with Hepatocellular Carcinoma

(2014) Kazuaki Ozaki et al.   Journal of Cancer

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

(2013) M Farhang Ghahremani et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

(2013) Miyako Kondoh et al.   PLoS One

Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment

(2012) Kosuke Akiyama et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterogeneity of Tumor Endothelial Cells

(2012) Noritaka Ohga et al.   AMERICAN JOURNAL OF PATHOLOGY

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells

(2012) K Yamamoto et al.   BRITISH JOURNAL OF CANCER

Centrosomes, chromosome instability (CIN) and aneuploidy

(2012) Benjamin D Vitre et al.   CURRENT OPINION IN CELL BIOLOGY

“Sprouting angiogenesis”, a reappraisal

(2012) Domenico Ribatti et al.   DEVELOPMENTAL BIOLOGY

Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis

(2012) Yuan Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

(2012) George D Demetri et al.   LANCET

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

(2012) Axel Grothey et al.   LANCET

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Endothelial precursor cells promote angiogenesis in hepatocellular carcinoma

(2012) Xi-Tai Sun   WORLD JOURNAL OF GASTROENTEROLOGY

To sprout or to split? VEGF, Notch and vascular morphogenesis

(2011) Roberto Gianni-Barrera et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells

(2011) Chikara Muraki et al.   INTERNATIONAL JOURNAL OF CANCER

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

(2011) F. M. Yakes et al.   MOLECULAR CANCER THERAPEUTICS

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Signaling Pathways Governing Tumor Angiogenesis

(2011) Toshiharu Sakurai et al.   ONCOLOGY

Defining Translational Research: Implications for Training

(2010) Doris McGartland Rubio et al.   ACADEMIC MEDICINE

Pericytes and vessel maturation during tumor angiogenesis and metastasis

(2010) Ahmad Raza et al.   AMERICAN JOURNAL OF HEMATOLOGY

Isolated tumor endothelial cells maintain specific character during long-term culture

(2010) Kohei Matsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels

(2010) S. M. Taylor et al.   BLOOD

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

(2010) Scott M. Wilhelm et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor Secretion of VEGF Induces Endothelial Cells to Suppress T cell Functions Through the Production of PGE2

(2010) Jennifer K. Mulligan et al.   JOURNAL OF IMMUNOTHERAPY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression

(2009) Dingcheng Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Horizontal transfer of tumor DNA to endothelial cells in vivo

(2009) J Ehnfors et al.   CELL DEATH AND DIFFERENTIATION

Human Hepatocellular Carcinoma Tumor-derived Endothelial Cells Manifest Increased Angiogenesis Capability and Drug Resistance Compared with Normal Endothelial Cells

(2009) Y.-Q. Xiong et al.   CLINICAL CANCER RESEARCH

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Endocan Expression and Localization in Human Glioblastomas

(2009) Claude-Alain Maurage et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Judah Folkman, a pioneer in the study of angiogenesis

(2008) Domenico Ribatti   ANGIOGENESIS

Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium

(2008) Carmen Ghilardi et al.   BMC GENOMICS

Molecular heterogeneity of tumor endothelium

(2008) William C. Aird   CELL AND TISSUE RESEARCH

VE-Cadherin

(2007) Dietmar Vestweber   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY