Article
Oncology
Cheng Su, Yufang Lv, Wenhao Lu, Zhenyuan Yu, Yu Ye, Bingqian Guo, Deyun Liu, Haibiao Yan, Tianyu Li, Qingyun Zhang, Jiwen Cheng, Zengnan Mo
Summary: This study identified new tumor-specific markers for different pathological types of RCC using single-cell transcriptome sequencing, as well as characterized different types of endothelial cells and their association with fibroblasts in ccRCC and type 2 pRCC. Furthermore, drug target pathway activation and drug response sensitivity were predicted in different pathological types of RCC based on scRNA-seq results.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Michiel C. van Aalderen, Rene A. W. van Lier, Pleun Hombrink
Summary: Our understanding of the functional complexity of CD8(+) T-cell populations has greatly increased in recent years, posing challenges in translating these insights into reliable phenotypic definitions. Current research focuses on the characterization of human CD8(+) T-cell subsets and the reliability of cell surface markers in relation to differentiation and function.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2021)
Review
Medical Laboratory Technology
Xavier Filella, Maria Rodriguez-Garcia, Esther Fernandez-Galan
Summary: Tumor markers are substances released by cancer cells into the bloodstream, providing valuable information for cancer patient management. However, interpreting and using tumor marker results correctly can be challenging, and various factors need to be considered. The Clinical Chemistry and Laboratory Medicine journal has played an important role in promoting the appropriate use of tumor markers.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Johanna Waidhauser, Pia Nerlinger, Tim Tobias Arndt, Stefan Schiele, Florian Sommer, Sebastian Wolf, Phillip Loehr, Stefan Eser, Gernot Mueller, Rainer Claus, Bruno Maerkl, Andreas Rank
Summary: Significant changes in circulating lymphocyte subsets were found in colon carcinoma patients, independent of physiological alterations due to gender or age. Some lymphocyte subsets showed significant differences according to tumor localization or MSI-status.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Oncology
Sara Corvigno, Anna Maria Johnson, Kwong-Kwok Wong, Min Soon Cho, Vahid Afshar-Kharghan, David G. Menter, Anil K. Sood
Summary: Liquid biopsy has emerged as a potential alternative for diagnosis and monitoring of tumors, overcoming the limitations of traditional radiologic imaging and histologic assessment. Various biomarkers can be detected in liquid biopsy, but reliable use requires the integration of multiple datasets.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Nako Maishi, Yu Sakurai, Hiroto Hatakeyama, Yui Umeyama, Takashi Nakamura, Rikito Endo, Mohammad Towfik Alam, Cong Li, Dorcas Akuba-Muhyia Annan, Hiroshi Kikuchi, Hirofumi Morimoto, Masahiro Morimoto, Kosuke Akiyama, Noritaka Ohga, Yasuhiro Hida, Hideyoshi Harashima, Kyoko Hida
Summary: This study explored the therapeutic effect of biglycan inhibition in renal cell carcinoma by using a specific nanodevice to deliver siRNA against biglycan into tumor endothelial cells (TECs). The results showed that biglycan silencing by the nanodevice inhibited tumor growth and normalized tumor microenvironmental factors.
Article
Immunology
Yefei Huang, Xinyu Wu, Lian Gui, Yutong Jiang, Liudan Tu, Xiaomin Li, Boxiong Jiang, Yina Wang, Xuqi Zheng, Qiujing Wei, Qiuxia Li, Jiayong Ou, Zena Chen, Ya Xie, Zhiming Lin, Zetao Liao, Linkai Fang, Minli Qiu, Shuangyan Cao, Jieruo Gu
Summary: Our study found that in gout patients, CD 4(+) T cells, Th2 cells, and Tc2 cells were upregulated, while Tc17 cells were downregulated. Tfh cells skewed towards Tfh2 cells polarization. Additionally, Tfh2 cells were associated with renal dysfunction in gout patients, while no alterations of B cell subsets were observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jie Zhang, Yang Hong, Liang Wang, Weiheng Hu, Guangming Tian, Di Wu, Yang Wang, Ling Dai, Ziran Zhang, Yue Yang, Jian Fang
Summary: This study aimed to detect and describe the distribution characteristics of circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with advanced lung cancer, and explore the correlation between CTC/CTEC subtypes and novel prognostic biomarkers. CTCs and CTECs derived from 52 patients with advanced lung cancer were identified using the subtraction enrichment-immunofluorescence in situ hybridization (SE-iFISH) system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Yuliang He, Carlotta Tacconi, Lothar C. Dieterich, Jihye Kim, Gaetana Restivo, Epameinondas Gousopoulos, Nicole Lindenblatt, Mitchell P. Levesque, Manfred Claassen, Michael Detmar
Summary: This study used single-cell RNA sequencing to uncover the molecular heterogeneity of blood vascular endothelial cells in healthy adult human skin. Six different subpopulations were identified, representing different blood vessel segments, each with distinct transcriptomic landscapes and marker expressions associated with specific functions.
Review
Oncology
Jing Liang, Shouqi Wang, Guowei Zhang, Baoyu He, Qingli Bie, Bin Zhang
Summary: Studying the differences, heterogeneity, and interaction of tumor-specific endothelial cells (TECs) with the tumor microenvironment is crucial for developing specific anti-tumor angiogenesis therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Young Jun Kim, Junhong Min
Summary: Liquid biopsy, which detects tumor-derived material noninvasively, has become a focus of attention due to its potential in precision medicine. However, the low frequency and purity of circulating tumor markers pose challenges to its development. Hydrogels, with their special characteristics, play a significant role in liquid biopsy by aiding in the isolation, protection, and analysis of these rare circulating biomarkers.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xing Huang, Yang Liu, Ao Feng, Xie Cheng, Xiangyu Xiong, Zimo Wang, Zhaoxia He, Jintang Guo, Shuai Wang, Xibo Yan
Summary: This study reports the development of photoactivated organic nanomachines powered by light-to-heat converting engines for programmable anticancer treatment. These nanomachines can be remotely controlled to enable light-driven thermophoresis and simultaneous thermal ablation of cancer cells. Their manipulability allows for improved cellular uptake and tumor penetration of anticancer drugs, resulting in enhanced antitumor efficacy.
Article
Biophysics
Soochul Shin, Sun Han, Juyoung Kim, Yumi Shin, Ji-Joon Song, Sungchul Hohng
Summary: SIMUL is a multiplexed ctDNA detection technique that can sensitively and specifically detect multiple single-nucleotide mutations in early cancer stages. It accurately measures mutant fractions and holds immense potential for clinical applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biotechnology & Applied Microbiology
Hui Ao, Zhuo Wang, Likang Lu, Hongwei Ma, Haowen Li, Jingxin Fu, Manzhen Li, Meihua Han, Yifei Guo, Xiangtao Wang
Summary: The study utilized blank PEGylated liposomes as tumor delivery enhancers and demonstrated that an over-threshold dosing strategy significantly enhanced the accumulation of liposomal drugs in tumors, leading to improved antitumor efficacy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Xiao Yang, Jiancheng Lv, Zijian Zhou, Dexiang Feng, Rui Zhou, Baorui Yuan, Qikai Wu, Hao Yu, Jie Han, Qiang Cao, Min Gu, Pengchao Li, Haiwei Yang, Qiang Lu
Summary: CTCs and CECs play a significant role in early intervention, treatment decision-making, and prognosis prediction in bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Juanjuan Qiu, Li Xu, Xiaohong Zeng, Hao Wu, Faqing Liang, Qing Lv, Zhenggui Du
Summary: CCL5 affects breast cancer metastasis and prognosis through CCR5, possibly mainly through T-cell-related immune pathways.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Haiming Zhao, Li Xu, Peng Tang, Rui Guo
Summary: In this meta-analysis, a lower baseline GNRI was found to be independently associated with poor survival outcomes in patients with colorectal cancer. Evaluating nutritional status using GNRI may be crucial for risk stratification in colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jie Tao, Lin Yin, Ao Wu, Jiaoli Zhang, Jingpu Zhang, Huichun Shi, Siyuan Liu, Liangfei Niu, Li Xu, Yanling Feng, Shixian Lian, Lei Li, Liyan Zeng, Xianmin Meng, Xiaohui Zhou, Tiefu Liu, Lijun Zhang
Summary: This study demonstrates the interaction between endoplasmic reticulum stress and metabolic reprogramming in promoting the malignant transformation of chronic inflammation, providing insights into the mechanisms underlying the contribution of chronic inflammation to cancer development.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chen Zhou, Li Xu, Zhenggui Du, Qing Lv
Summary: This study investigated the benefit of chemotherapy in geriatric patients with early-stage TNBC and identified the proper population who might omit chemotherapy. A nomogram predicting BCSS was constructed, and chemotherapy could not improve prognosis of patients in the low-risk group. Sparing chemotherapy in low-risk subgroup was feasible without sacrificing survival, providing clinicians tools to weigh the risk-benefit of chemotherapy and customize the individualized treatment accordingly.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Xiaofan Lu, Yann Vano, Alexandra Helleux, Xiaoping Su, Veronique Lindner, Guillaume Davidson, Roger Mouawad, Jean-Philippe Spano, Morgan Roupre, Reza Elaidi, Eva Comperat, Virginie Verkarre, Chengming Sun, Christine Chevreau, Mostefa Bennamoun, Herve Lang, Thibault Tricard, Wenxuan Cheng, Li Xu, Irwin Davidson, Fangrong Yan, Wolf Herman Fridman, Catherine Sautes-Fridman, Stephane Oudard, Gabriel G. Malouf
Summary: This study identified a novel epigenetic phenotype associated with resistance to immune checkpoint inhibitors (ICIs) in clear-cell renal cell carcinomas (ccRCC). This phenotype, called TED, was found to be associated with sarcomatoid differentiation, poor clinical outcome and resistance to first-line ipilimumab-nivolumab combination therapy. TED exhibited specific epigenetic alterations, gene expression signatures and tumor microenvironment characteristics.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Xingxiang Pu, QianZhi Wang, Liyu Liu, Bolin Chen, Kang Li, Yu Zhou, Zengmei Sheng, Ping Liu, Yucheng Tang, Li Xu, Jia Li, Yi Kong, Fang Xu, Yan Xu, Lin Wu
Summary: The combination of rh-endostatin, camrelizumab, and chemotherapy showed promising efficacy and safety in patients with advanced NSCLC.
Article
Oncology
Zi-liang Yang, Xu-qi Sun, Yu-hao Tang, Pei-yao Xiong, Li Xu
Summary: Liver resection (LR) remains the best choice for AJCC stage I hepatocellular carcinoma (HCC) patients, regardless of tumor size. For HCC ≤ 2 cm, stereotactic body radiation therapy (SBRT) can be an alternative treatment to radiofrequency ablation (RFA). For HCC > 2 cm, RFA provides better long-term survival than SBRT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Anesthesiology
Jonas Alfitian, Jarrod Basto, Jan Miestereck, Hilmy Ismail, Kwok-Ming Ho, Tobias Kammerer, Volker Schick, Bernhard Riedel, Robert Schier
Summary: This study investigated the association between two parameters (end-tidal CO2 and heart rate) during cardiopulmonary exercise testing and resting diffusion capacity with postoperative complications and survival. The findings suggest that dynamic assessment of end-tidal CO2 during early exercise and resting diffusion capacity may serve as inexpensive triage tools for preoperative risk assessment.
MINERVA ANESTESIOLOGICA
(2023)
Article
Oncology
Chenhao Yu, Li Xu, Liyin Ye, Qiming Zheng, Haiyi Hu, Kangxin Ni, Chenghao Zhou, Dingwei Xue, Sheng Cheng, Hui Wang, Raymond Wei Pak, Gonghui Li
Summary: This study retrospectively analyzed the clinical data of 50 patients and evaluated the early functional and oncological outcomes of single-port robot-assisted perineal radical prostatectomy using the da Vinci XI system. The results showed that this surgical approach is feasible and reliable, with good postoperative functional and oncological outcomes. The cumulative sum analysis identified 20 cases as the turning point for surgeons to master the novel technique.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Immunology
Yangxun Pan, Xiaodong Zhu, Jianwei Liu, Jianhong Zhong, Wei Zhang, Shunli Shen, Renan Jin, Hongzhi Liu, Feng Ye, Kuan Hu, Da Xu, Yu Zhang, Zhong Chen, Baocai Xing, Ledu Zhou, Yongjun Chen, Yongyi Zeng, Xiao Liang, Ming Kuang, Tianqiang Song, Bangde Xiang, Kui Wang, Huichuan Sun, Li Xu
Summary: This study investigated the survival benefit of concurrent transcatheter intra-arterial therapies (TRITs) and systemic therapy used as first-line treatment for unresectable hepatocellular carcinoma (uHCC) patients in China. The results showed that the combination of TRIT and systemic therapy was associated with improved overall survival in uHCC patients, especially those with high-intrahepatic tumor load and no extrahepatic metastasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Lei Ao, Dongjie Shi, Dan Liu, Hua Yu, Li Xu, Yongzhi Xia, Shilei Hao, Yaying Yang, Wenjie Zhong, Junjie Zhou, Haijian Xia
Summary: This study constructed a predictive model using common clinical characteristics, which had good prognostic value for patients with diffuse low-grade gliomas (DLGGs, WHO grade 2) and could assist physicians in making clinical decisions.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Bowen Shi, Chunguang Li, Wenqiang Xia, Yuerong Chen, Hezhong Chen, Li Xu, Ming Qin
Summary: This study developed a new prognostic model for esophageal squamous cell carcinoma that can effectively predict individual overall survival. The accuracy and reliability of this model were higher than that of the TNM staging system. It provides a theoretical basis for clinical decision making.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Yansheng Yao, Peng Ji, Hao Chen, Jianwen Ge, Yajing Xu, Peng Wang, Li Xu, Zhirong Yan
Summary: Brain tumors are malignant tumors with brutal treatment and high recurrence rate. Surgery, radiotherapy, and chemotherapy are commonly used, but have toxic side effects. Therefore, it is urgent to explore new strategies, methods, and technologies to improve the treatment of brain tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Orthopedics
Jonas Alfitian, Max Joseph Scheyerer, Axel Rohde, Volker Schick, Tobias Kammerer, Robert Schier
Summary: This study aims to investigate whether prophylactic use of tranexamic acid (TXA) is necessary for relatively less invasive spine surgeries, such as one-level posterior spinal fusion. After propensity score matching, the results showed that omission of TXA did not affect the requirement for blood transfusions in these surgeries.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Meeting Abstract
Oncology
Lin Wu, Bolin Chen, Jingyi Wang, Xingxiang Pu, Jia Li, Qianzhi Wang, Liyu Liu, Yan Xu, Li Xu, Yi Kong, Kang Li, Fang Xu, Shuzhi Liang
JOURNAL OF CLINICAL ONCOLOGY
(2022)