Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers
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Title
Dysregulation of Type II Transmembrane Serine Proteases and Ligand-Dependent Activation of MET in Urological Cancers
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 8, Pages 2663
Publisher
MDPI AG
Online
2020-04-13
DOI
10.3390/ijms21082663
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Note: Only part of the references are listed.- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
- (2020) Shutoku Matsuyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell surface–anchored serine proteases in cancer progression and metastasis
- (2019) Carly E. Martin et al. CANCER AND METASTASIS REVIEWS
- Investigational MET inhibitors to treat Renal cell carcinoma
- (2019) Lakshminarayanan Nandagopal et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
- (2019) Wen Jing Sim et al. Nature Communications
- Molecular Composition of Genomic TMPRSS2-ERG Rearrangements in Prostate Cancer
- (2019) Manuela Krumbholz et al. DISEASE MARKERS
- Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression
- (2018) Fernanda Marconi Roversi et al. BIOMEDICINE & PHARMACOTHERAPY
- Cabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial
- (2018) Bernard Escudier et al. JOURNAL OF CLINICAL ONCOLOGY
- Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): Emerging key players in epithelial integrity and cancer
- (2018) Hiroaki Kataoka et al. PATHOLOGY INTERNATIONAL
- Hereditary renal cell carcinoma syndromes: diagnosis, surveillance and management
- (2018) Eamonn R. Maher WORLD JOURNAL OF UROLOGY
- Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells
- (2018) Koji Yamamoto et al. Oncotarget
- Dysregulated HAI-2 Plays an Important Role in Renal Cell Carcinoma Bone Metastasis through Ligand-Dependent MET Phosphorylation
- (2018) Koji Yamasaki et al. Cancers
- Matriptase-Induced Phosphorylation of MET is Significantly Associated with Poor Prognosis in Invasive Bladder Cancer; an Immunohistochemical Analysis
- (2018) Koji Yamasaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate
- (2018) Jiaqi Mi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
- (2017) Chuan-Jin Wu et al. JOURNAL OF CLINICAL INVESTIGATION
- The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database
- (2017) Neil D Rawlings et al. NUCLEIC ACIDS RESEARCH
- miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer
- (2017) Tao Ning et al. TUMOR BIOLOGY
- The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells
- (2017) Terumichi Shintani et al. UROLOGY
- Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation
- (2017) Benjamin Y. Owusu et al. Oncotarget
- The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
- (2017) Shang-Ru Wu et al. Scientific Reports
- α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer
- (2016) Zhenfu Han et al. ChemMedChem
- The role of type II transmembrane serine protease-mediated signaling in cancer
- (2016) Lauren M. Tanabe et al. FEBS Journal
- Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1
- (2016) Matthew Smith et al. JOURNAL OF CLINICAL ONCOLOGY
- Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial
- (2016) Toni K Choueiri et al. LANCET ONCOLOGY
- MET expression during prostate cancer progression
- (2016) Esther I. Verhoef et al. Oncotarget
- C-met inhibition blocks bone metastasis development induced by renal cancer stem cells
- (2016) Lucia D'Amico et al. Oncotarget
- Mechanistic Support for Combined MET and AR Blockade in Castration-Resistant Prostate Cancer
- (2016) Yuanyuan Qiao et al. NEOPLASIA
- Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets
- (2015) Francisco M. Franco et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
- (2015) C.-J. Ko et al. CANCER RESEARCH
- SPINT2 Deregulation in Prostate Carcinoma
- (2015) Márcia Santos Pereira et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Epigenetic Silencing of SPINT2 Promotes Cancer Cell Motility via HGF-MET Pathway Activation in Melanoma
- (2015) Soonyean Hwang et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Expression of human kallikrein 1-related peptidase 4 (KLK4) and MET phosphorylation in prostate cancer tissue: immunohistochemical analysis
- (2015) Shoichiro Mukai et al. Human Cell
- Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis
- (2015) Xi Tang et al. Oncotarget
- Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs
- (2014) S. Pennacchietti et al. CANCER RESEARCH
- Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma
- (2014) Ming-Fang Cheng et al. HISTOPATHOLOGY
- Preliminary evaluation of urinary soluble Met as a Biomarker for urothelial carcinoma of the bladder
- (2014) Brian K McNeil et al. Journal of Translational Medicine
- Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer
- (2014) Zhenfu Han et al. ACS Medicinal Chemistry Letters
- The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
- (2014) J. M. Lucas et al. Cancer Discovery
- Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis
- (2014) Shoichiro Mukai et al. Human Cell
- Met in Urological Cancers
- (2014) Yasuyoshi Miyata et al. Cancers
- Characterization of HGF/Met Signaling in Cell Lines Derived From Urothelial Carcinoma of the Bladder
- (2014) Young Lee et al. Cancers
- Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues
- (2014) Makiko Kawaguchi et al. Cancers
- Targeting the Hepatocyte Growth Factor/c-Met Signaling Pathway in Renal Cell Carcinoma
- (2013) Lauren C. Harshman et al. CANCER JOURNAL
- Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Suppressor of Intestinal Tumorigenesis
- (2013) S. Hoshiko et al. CANCER RESEARCH
- Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model
- (2013) Jingjia Ye et al. CANCER SCIENCE
- Epigenetic inactivation of SPINT2 is associated with tumor suppressive function in esophageal squamous cell carcinoma
- (2013) Dongli Yue et al. EXPERIMENTAL CELL RESEARCH
- HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase
- (2013) C-H Tsai et al. ONCOGENE
- Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation—diversity, ductility, and destiny
- (2012) Kenichi Suda et al. CANCER AND METASTASIS REVIEWS
- Protease signalling: the cutting edge
- (2012) Boris Turk et al. EMBO JOURNAL
- Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness
- (2012) Takashi Baba et al. JOURNAL OF PATHOLOGY
- Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity
- (2011) Makiko Kawaguchi et al. AMERICAN JOURNAL OF PATHOLOGY
- Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology
- (2011) Roman Szabo et al. Annual Review of Cell and Developmental Biology
- A direct role for Met endocytosis in tumorigenesis
- (2011) Carine Joffre et al. NATURE CELL BIOLOGY
- A Novel Signaling Axis of Matriptase/PDGF-D/ -PDGFR in Human Prostate Cancer
- (2010) C. V. Ustach et al. CANCER RESEARCH
- Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells
- (2010) Tsuyoshi Fukushima et al. CANCER SCIENCE
- Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo
- (2010) Hiroaki Kataoka et al. FEBS Journal
- Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancer
- (2010) Wenjie Dong et al. INTERNATIONAL JOURNAL OF CANCER
- The role of hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2 in endometrial cancer
- (2010) Keiichiro Nakamura et al. INTERNATIONAL JOURNAL OF CANCER
- MET signalling: principles and functions in development, organ regeneration and cancer
- (2010) Livio Trusolino et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Loss of the matriptase inhibitor HAI-2 during prostate cancer progression
- (2010) Christopher Bergum et al. PROSTATE
- Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
- (2009) Kate A. Owen et al. BIOCHEMICAL JOURNAL
- Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis
- (2009) W. Li et al. CANCER RESEARCH
- Hepatocyte Growth Factor Activator Inhibitor Type 1 Regulates Epithelial to Mesenchymal Transition through Membrane-Bound Serine Proteinases
- (2009) H. Cheng et al. CANCER RESEARCH
- Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase–2 and –7 and E-cadherin
- (2009) Yasuyoshi Miyata et al. HUMAN PATHOLOGY
- The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer
- (2009) Nakamura INTERNATIONAL JOURNAL OF ONCOLOGY
- Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model
- (2009) Srinivas Nandana et al. PROSTATE
- The Met tyrosine kinase receptor in development and cancer
- (2008) Alessandra Gentile et al. CANCER AND METASTASIS REVIEWS
- Laminin-332 Is a Substrate for Hepsin, a Protease Associated with Prostate Cancer Progression
- (2008) Manisha Tripathi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma
- (2008) JM Lucas et al. JOURNAL OF PATHOLOGY
- Protein Expression of Matriptase and its Cognate Inhibitor HAI-1 in Human Prostate Cancer
- (2008) Miranda Warren et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
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